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Cat. No.: HY-107331

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Chlorproguanil

Chlorproguanil is an antifolate with an IC₅₀ of 4.68 μM against Plasmodium falciparum female gamete formation. Chlorproguanil can be used for the research of malaria.

For research use only. We do not sell to patients.

CAS No.: 537-21-3
Formula: C₁₁H₁₅Cl₂N₅
Molecular Weight:288.18

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Chlorproguanil Chemical Structure

CAS No.: 537-21-3

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- Clinical Trial
Chemical Information
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Biological Activity

Description

Chlorproguanil is an antifolate with an IC₅₀ of 4.68 μM against Plasmodium falciparum female gamete formation. Chlorproguanil can be used for the research of malaria^[1].

All Parasite Isoforms :

In Vitro

Chlorproguanil (0-25 μM; 48 h) inhibits P. falciparum stage V female gametocyte activation with a mean IC₅₀ of 4.68 μM following 48 h incubation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

Chemical Information

CAS No. 537-21-3
Molecular Weight 288.18
Formula C₁₁H₁₅Cl₂N₅
SMILES

ClC1=CC=C(C=C1Cl)NC(=N)NC(=N)NC(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Miguel-Blanco C, et al. Imaging-based high-throughput screening assay to identify new molecules with transmission-blocking potential against Plasmodium falciparum female gamete formation. Antimicrob Agents Chemother. 2015;59(6):3298-305. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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- In Vitro
- Clinical Trial
Chemical Information
Purity & Documentation
References

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Chlorproguanil

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Chlorproguanil Related Classifications

HY-107331 Related Classifications