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Cat. No.: HY-108029

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Deldeprevir sodium

(Synonyms: ACH-2684 sodium; Neceprevir sodium)

Deldeprevir (ACH-2684; Neceprevir) sodium is a HCV NS3/4A protease inhibitor and resistance inhibitor. Deldeprevir sodium exhibits activity against wild-type genotype 1a and 1b HCV, including mutant strains resistant to other NS3 protease inhibitors. Deldeprevir sodium blocks the emergence of HCV mutant strains resistant to ACH-3422 in vitro, with enhanced efficacy when used in triple combination with ACH-3422 and ACH-3102 (HY-124182). Deldeprevir sodium shows additive antiviral potency when combined with ACH-3422, and exerts antiviral activity against HCV replicons carrying ACH-3102. Deldeprevir sodium is applicable to research related to hepatitis C.

For research use only. We do not sell to patients.

CAS No.: 1298053-61-8
Formula: C₄₅H₅₅F₂N₆NaO₈S₂
Molecular Weight:933.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Deldeprevir sodium Chemical Structure

CAS No.: 1298053-61-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

In Vitro

Deldeprevir sodium (3 days; antiviral combination study) exhibits higher in vitro potency against genotype-1a and 1b HCV replicons than BMS-032, and its combination with ACH-3102 reduces the emergence of resistance variants in these replicon cell lines^[1].
ACH-2684 (Deldeprevir sodium) (3 days) exhibits higher in vitro potency against genotype 1a and 1b HCV replicons than a reference NS3 protease inhibitor, and displays additive or synergistic antiviral efficacy when combined with a HCV NS5A inhibitor while reducing resistance variant emergence^[2].
Combining Deldeprevir sodium with the NS5B nucleotide inhibitor ACH-3422, or with ACH-3422 plus the NS5A inhibitor ACH-3102, enhances antiviral activity and blocks the emergence of ACH-3422-resistant HCV replicons in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1298053-61-8
Molecular Weight 933.07
Formula C₄₅H₅₅F₂N₆NaO₈S₂
SMILES

O=C([C@]([C@]1([H])/C=C\CCCCC[C@@H]2CC(N3CC(F)(F)CCC3)=O)(C1)NC([C@@](C[C@@H](OC4=CC(C5=NC(C(C)C)=CS5)=NC6=C(C)C(OC)=CC=C46)C7)([H])N7C2=O)=O)N([Na])S(=O)(C8CC8)=O
Synonyms

ACH-2684 sodium; Neceprevir sodium
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhao Y, et al. In VitroStudies Demonstrate a High Probability of Curing Genotype-1 Hepatitis C Patients with Combination of a Novel NS3 Protease Inhibitor ACH-2684 and a Novel NS5A Inhibitor ACH-3102: 1886[J]. Hepatology, 2012, 56: 1071A-1072A.

[2]. Baglino S L, et al. Pegylated Interferons Lambda-1a and Alfa-2a Display Different Gene Induction and Cytokine Release Profiles in Both Human Hepatocytes and Peripheral Blood Mononuclear Cells: 1885[J]. Hepatology, 2012, 56: 1071A.

[3]. Zhou X J, et al. Pharmacokinetics and Drug-Drug Interaction between Samatasvir, an NS5A Inhibitor, and Co-administered Simeprevir, an NS3/4A Protease Inhibitor, and Low Dose Ritonavir-Boosted TMC647055, a Non-Nucleoside NS5B Inhibitor, in Healthy Volunteers and HCV-Infected Subjects: 1987[J]. Hepatology, 2014, 60: 1167A-1168A.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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