2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P990227
    Anti-Mouse IL-12 Antibody (R1-5D9)
    Anti-Mouse IL-12 Antibody (R1-5D9) is a rat-derived IgG2a type antibody inhibitor, targeting to mouse IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can neutralize IL-12. Anti-Mouse IL-12 Antibody (R1-5D9) can be used for the researches of infection, inflammation and immunology, such as Leishmania infection and skin inflammation.
    Anti-Mouse IL-12 Antibody (R1-5D9)
  • HY-P990394
    Anti-CXCR3/GPR9/CD183 Antibody 98.45%
    Anti-CXCR3/GPR9/CD183 Antibody is a human-derived antibody expressed in CHO, targeting CXCR3/GPR9/CD183. The Anti-CXCR3/GPR9/CD183 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. For the isotype control of Anti-CXCR3/GPR9/CD183 Antibody, please refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-CXCR3/GPR9/CD183 Antibody
  • HY-P990405
    Anti-EphB2 Antibody 99.36%
    The Anti-EphB2 Antibody is a CHO expressed human antibody that targets EphB2. The Anti-EphB2 Antibody has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for the Anti-EphB2 Antibody can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-EphB2 Antibody
  • HY-P990446
    Anti-IL-15 Antibody (DISC0280) 99.35%
    The Anti-IL-15 Antibody (DISC0280) is a CHO-expressed human antibody that targets IL-15. The Anti-IL-15 Antibody (DISC0280) has a huIgG1 heavy chain and a huλ light chain, with a predicted molecular weight (MW) of 145 kDa. The isotype control for Anti-IL-15 Antibody (DISC0280) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-IL-15 Antibody (DISC0280)
  • HY-P990489
    Anti-PDGFRB/CD140b Antibody (IMC-2C5) 99.90%
    Anti-PDGFRB/CD140b Antibody (IMC-2C5) is a humanized antibody expressed in CHO cells that targets PDGFRB/CD140b. Anti-PDGFRB/CD140b Antibody (IMC-2C5) contains huIgG1 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 145.54 kDa. The isotype control for Anti-PDGFRB/CD140b Antibody (IMC-2C5) can be referenced as Human IgG1 kappa, Isotype Control (HY-P99001).
    Anti-PDGFRB/CD140b Antibody (IMC-2C5)
  • HY-P990515
    Anti-TCR Antibody (NKTT320) 98.90%
    Anti-TCR Antibody (NKTT320) is a humanized antibody expressed in CHO, targeting TCR. Anti-TCR Antibody (NKTT320) features huIgG4 heavy chain and huκ light chain, with a predicted molecular weight (MW) of 150 kDa. The isotype control for Anti-TCR Antibody (NKTT320) can refer to Human IgG4 kappa, Isotype Control (HY-P99003).
    Anti-TCR Antibody (NKTT320)
  • HY-P990549
    ASK-8007 99.25%
    ASK-8007 is a humanized antibody expressed by CHO, targeting Osteopontin. ASK-8007 has a huIgG1 heavy chain and a huκ light chain, with a predicted molecular weight (MW) of 145.02 kDa. The isotype control for ASK-8007 can refer to Human IgG1 kappa, Isotype Control (HY-P99001).
    ASK-8007
  • HY-P990623
    MDX-1105 ≥99.0%
    MDX-1105 is a human antibody expressed in CHO that targets B7-H1/PD-L1/CD274. MDX-1105 has a huIgG4SP type heavy chain, and its predicted molecular weight (MW) is 150 kDa. The isotype control for MDX-1105 can be referenced as Human IgG4 kappa, Isotype Control (HY-P99003).
    MDX-1105
  • HY-P990903
    Avitotamig 2577961-36-3
    HY-P990903 is an CD3E/CD33-targeting [H-γ1 _ L-κ-scFv heavy -κ]-dimer type bispecific antibody.
    Avitotamig
  • HY-P990929
    Misitatug 2767203-01-8 99.00%
    HY-P990929 is an MSLN-targeting IgG1κ type chimeric antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Misitatug
  • HY-P991290
    IRAB-B 98.30%
    IRAB-B is a human monoclonal antibody targeting INSR. IRAB-B is an insulin receptor (IR) antagonist and can be used in the study of insulin resistance and diabetes.
    IRAB-B
  • HY-P991363
    AX-202 98.91%
    AX-202 is a humanized IgG4 monoclonal antibody targeting S100A4. AX-202 neutralizes the activity of S100A4. AX-202 effectively reverses established fibrosis and reduces inflammation and fibrosis-related biomarkers in a mouse model of skin fibrosis. AX-202 is applicable for the research of fibrotic and inflammatory diseases.
    AX-202
  • HY-W011309
    1-O-Hexadecylglycerol 6145-69-3 99.96%
    1-O-Hexadecylglycerol can up-regulate PPAR-γ expression, inhibit pGE2, and exhibit anti-inflammatory properties. 1-O-Hexadecylglycerol is effective in oral administration.
    1-O-Hexadecylglycerol
  • HY-W782399
    CORM-A1 17363-08-5
    CORM-A1 (Sodium boranocarbonate) is a water-soluble carbon monoxide (CO) releasing molecule that facilitates the investigation of CO's impact on cellular systems. As CO is generated from heme degradation by the enzyme heme oxygenase, it serves as a crucial gaseous signaling mediator in mammalian cells. CORM-A1 not only exhibits anti-oxidant and anti-inflammatory properties but also regulates CO release in a manner dependent on pH and temperature, promoting mild vasorelaxation and hypotension. Furthermore, CORM-A1 has been shown to provide cytoprotection in primary cultures of astrocytes under oxidative stress while also enhancing autophagy due to its boron-containing composition.
    CORM-A1
  • HY-W002292R
    L-Homoserine (Standard) 672-15-1 99.97%
    L-Homoserine (Standard) is the analytical standard of L-Homoserine (HY-W002292). This product is intended for research and analytical applications. L-Homoserine is a nonessential chiral amino acid and the precursor of L-Threonine (HY-N0658) and L-Methionine (HY-N0326). L-Homoserine wide applications in the fields of pharmaceutical, agricultural, cosmetic and fragrance industries.
    L-Homoserine (Standard)
  • HY-13277
    IRAK inhibitor 3 1012343-93-9 98.86%
    IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
    IRAK inhibitor 3
  • HY-16902
    RO9021 1446790-62-0 98.88%
    RO9021 is an orally bioavailable, novel ATP-competitive inhibitor of SYK, with an average IC50 of 5.6 nM.
    RO9021
  • HY-19830
    AN3199 1187187-10-5 99.76%
    AN3199 is a PDE4 inhibitor with an IC50 of 94.5 nM. AN3199 can be used for the research of inflammation-associated diseases such as asthma and chronic obstructive pulmonary disease (COPD).
    AN3199
  • HY-163428
    Perzebertinib 2414056-31-6 98%
    ZN-A-1041 inhibits HER2 in BT474 cell and wt-EGFR in H838 cells, with IC50s of 9.5 nM and 12 μM respectively. ZN-A-1041 can be used for research of cancer and inflammation.
    Perzebertinib
  • HY-19778A
    BPO-27 racemate 1314873-02-3 98.50%
    BPO-27 racemate is a potent CFTR inhibitor with an IC50 of 8 nM.
    BPO-27 racemate
Cat. No. Product Name / Synonyms Application Reactivity