1. Immunology/Inflammation
  2. IRAK
  3. IRAK inhibitor 3

IRAK inhibitor 3 

Cat. No.: HY-13277 Purity: 98.17%
Handling Instructions

IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.

For research use only. We do not sell to patients.

IRAK inhibitor 3 Chemical Structure

IRAK inhibitor 3 Chemical Structure

CAS No. : 1012343-93-9

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 319 In-stock
Estimated Time of Arrival: December 31
5 mg USD 290 In-stock
Estimated Time of Arrival: December 31
10 mg USD 396 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1030 In-stock
Estimated Time of Arrival: December 31
100 mg   Get quote  
200 mg   Get quote  

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Description

IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.

IC50 & Target

IRAK[1]

In Vitro

IRAK inhibitor 3 is an IRAK modulator, which can be used for treating an inflammatory condition, cell proliferative disorder, immune disorder[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

439.49

Formula

C₂₁H₂₁N₅O₄S

CAS No.

1012343-93-9

SMILES

O=S(C1=CC=C(CNC2=NN3C(C4=CC(OC)=C(C=C4)OC)=CN=C3C=C2)C=C1)(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 13 mg/mL (29.58 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2754 mL 11.3768 mL 22.7536 mL
5 mM 0.4551 mL 2.2754 mL 4.5507 mL
10 mM 0.2275 mL 1.1377 mL 2.2754 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Kinase Assay
[1]

5 μL of a solution of IRAK inhibitor 3 at a concentration of 50 μM or less in 1% (v/v) DMSO is added to the wells of a 96-well area Black Polystyrene plates. The final concentrations in the reaction well are 10 μM ATP, 0.5 μM IRAK4 CH373, 1.6 μM IRAKI peptide, 1 mM MgCl2, 2 mM DTT, 5 mM MnCl2, 0.01 % BSA, and 0.01 % Tween-20. The volume of the reaction is 45 μL. The reaction mixture is incubated at room temperature for 30 minutes and stopped with the addition of 5 μL of 100 mM EDTA[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
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Keywords:

IRAK inhibitor 3IRAK inhibitor3IRAK inhibitor-3IRAKInterleukin-1 receptor associated kinaseIL-1R associated kinaseInhibitorinhibitorinhibit

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Product Name:
IRAK inhibitor 3
Cat. No.:
HY-13277
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