IRAK inhibitor 3
Based on 1 publication(s) in Google Scholar
IRAK inhibitor 3 is an interleukin-1 (IL-I) receptor-associated kinase (IRAK) kinase modulator extracted from patent WO2008030579 A2.
For research use only. We do not sell to patients.
- Purity: 98.86%
- CAS No.: 1012343-93-9
- Formula: C21H21N5O4S
- Molecular Weight:439.49
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 2 years , -20°C, 1 year
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) IRAK inhibitor 3
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Biological Activity
IRAK[1]
IRAK inhibitor 3 is an IRAK modulator, which can be used for treating an inflammatory condition, cell proliferative disorder, immune disorder[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1012343-93-9
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Appearance Solid
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Molecular Weight 439.49
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Formula C21H21N5O4S
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Color Off-white to gray
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SMILES
O=S(C1=CC=C(CNC2=NN3C(C4=CC(OC)=C(C=C4)OC)=CN=C3C=C2)C=C1)(N)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 2 years -20°C 1 year
Publications (1)
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Journal Impact Factor
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Most Recent
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Neurotherapeutics
α7-Acetylcholine Receptor Signaling Reduces Neuroinflammation After Subarachnoid Hemorrhage in Mice. [Abstract]2021 Jul;18(3):1891-1904. PMID: 33970466
Solvent & Solubility
DMSO : 13 mg/mL (29.58 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
5 μL of a solution of IRAK inhibitor 3 at a concentration of 50 μM or less in 1% (v/v) DMSO is added to the wells of a 96-well area Black Polystyrene plates. The final concentrations in the reaction well are 10 μM ATP, 0.5 μM IRAK4 CH373, 1.6 μM IRAKI peptide, 1 mM MgCl2, 2 mM DTT, 5 mM MnCl2, 0.01 % BSA, and 0.01 % Tween-20. The volume of the reaction is 45 μL. The reaction mixture is incubated at room temperature for 30 minutes and stopped with the addition of 5 μL of 100 mM EDTA[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Purity & Documentation
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2754 mL | 11.3768 mL | 22.7536 mL | 56.8841 mL |
| 5 mM | 0.4551 mL | 2.2754 mL | 4.5507 mL | 11.3768 mL | |
| 10 mM | 0.2275 mL | 1.1377 mL | 2.2754 mL | 5.6884 mL | |
| 15 mM | 0.1517 mL | 0.7585 mL | 1.5169 mL | 3.7923 mL | |
| 20 mM | 0.1138 mL | 0.5688 mL | 1.1377 mL | 2.8442 mL | |
| 25 mM | 0.0910 mL | 0.4551 mL | 0.9101 mL | 2.2754 mL |
IRAK inhibitor 3 Related Classifications
HY-13277 Related Classifications
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