2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-148328
    CK2-IN-4 313985-59-0 99.24%
    CK2-IN-4 (compound 5) is a protein kinase (CK2) inhibitor (IC50=8.6 µM). CK2-IN-4 has good potential for research in the areas of cancer, viral infections and glomerulonephritis.
    CK2-IN-4
  • HY-148382
    RI-962 2763831-53-2 99.50%
    RI-962 is a potent and selective receptor-interacting protein kinase 1 (RIPK1) inhibitor. RI-962 inhibits RIPK1 with an IC50 value of 35.0 nM. RI-962 can be used for the research of nervous system diseases and inflammatory diseases.
    RI-962
  • HY-148432
    FGF22-IN-1 113143-13-8 98.07%
    FGF22-IN-1 (compound c1) is a potent CD4 D1 inhibitor. FGF22-IN-1 can be used as immunosuppressive agent.
    FGF22-IN-1
  • HY-148433
    SpdSyn binder-1 251106-30-6
    SpdSyn binder-1 is a weak binder, which binds in the active site of plasmodium falciparum spermidine synthase. SpdSyn binder-1 can be used for the research of malaria.
    SpdSyn binder-1
  • HY-148552
    Anti-inflammatory agent 35 2293951-00-3 99.77%
    Anti-inflammatory agent 35 (compound 5a27) is an orally active curcumin analogue with anti-inflammatory activity. Anti-inflammatory agent 35 blocks mitogen-activated protein kinase (MAPK) signaling and p65 nuclear translocation of NF-kB. Anti-inflammatory agent 35 also inhibits yellow neutrophil infiltration and pro-inflammatory cytokine production. Anti-inflammatory agent 35 significantly attenuates lipopolysaccharide (LPS)-induced acute lung injury (ALI) in vivo.
    Anti-inflammatory agent 35
  • HY-148608
    LysoPalloT-NH-amide-C3-ph-m-O-C11 1778686-61-5 98%
    LysoPalloT-NH-amide-C3-ph-m-O-C11 is an agonist for GPR174 with an EC50 of 34 nM.
    LysoPalloT-NH-amide-C3-ph-m-O-C11
  • HY-148918
    E722-2648 931963-55-2 98%
    E722-2648 is an inhibitor targeting the BCL9 and β-catenin complex with antitumor activity. E722-2648 blocks complex formation by disrupting the interaction between the two proteins, thereby inhibiting β-catenin-mediated transcriptional activity and downregulating the expression of WNT target genes. E722-2648 effectively inhibits tumor growth in colon cancer xenograft models and colorectal cancer mouse models. E722-2648 can be used for the research of colon cancer and colorectal cancer.
    E722-2648
  • HY-148925
    α-Amyrenone 638-96-0 98.83%
    α-Amyrenone is a triterpenoid that occurs naturally in very low concentrations in several oleoresins from Brazilian Amazon species of Protium (Burseraceae). The mixture of α and β-amyrenone inhibits α-glucosidase, and can reduce mechanical hypersensitivity and paw-oedema induced by carrageenan.
    α-Amyrenone
  • HY-149008
    α-Amylase-IN-3 93944-58-2 99.49%
    α-Amylase-IN-3 (Compound 4) is the inhibitor for α-Amylase, AChE and AChE with IC50s of 18.04 μM, 21.04 μM and 22.2 μM, respectively. α-Amylase-IN-3 exhibits antioxidant activity. α-Amylase-IN-3 can be used in research of diabetes and oxidative stress associated disease.
    α-Amylase-IN-3
  • HY-14915A
    Bedoradrine sulfate 194785-31-4 99.31%
    Bedoradrine (MN-221) sulfate is a highly selective β2-adrenergic receptor agonist. Bedoradrine sulfate can effectively relieve airway spasm, dilate airway smooth muscle cells, reduce airway inflammation, and thus improve respiratory function. Bedoradrine sulfate can be used in research on asthma.
    Bedoradrine sulfate
  • HY-149281
    IL-1β-IN-1 2780364-50-1 99.45%
    IL-1β-IN-1, cannabidiol derivative, is a potent IL-1β inhibitor. IL-1β-IN-1 has anti-inflammatory and pain-resolving properties.
    IL-1β-IN-1
  • HY-149503
    4-Hydroxy nebivolol hydrochloride 2717115-85-8 99.4%
    4-Hydroxy nebivolol (4-OH nebivolol) hydrochloride is an active β-blocking hydroxylated metabolite of Nebivolol (HY-B0203).
    4-Hydroxy nebivolol hydrochloride
  • HY-149650
    TLR4 agonist-1 2374139-51-0 98%
    TLR4 agonist-1 (compound 17a) is a potent agonist of Toll-like Receptor 4 (TLR4), and induces the generation of MIP-1β in RAW 264.7 and MM6 cells.
    TLR4 agonist-1
  • HY-150156
    Anti-inflammatory agent 32 2577388-38-4 99.52%
    Anti-inflammatory agent 32 is a chalcone derivative with anti-inflammatory activity. Anti-inflammatory agent 32 can be used for the research of inflammatory bowel disease.
    Anti-inflammatory agent 32
  • HY-150212
    Tilsotolimod 1948266-37-2 99.46%
    Tilsotolimod (IMO-2125) is a TLR9 agonist. Tilsotolimod activates the TLR9 signaling pathway, triggers downstream pro-inflammatory and immunostimulatory pathways, enhances the uptake and killing of cancer cells, and induces adaptive immune responses. Tilsotolimod is applicable to research related to melanoma and colorectal cancer.
    Tilsotolimod
  • HY-150226
    Enzyme-IN-1 868540-02-7
    Enzyme-IN-1 (compound 1) is a peptide-based inhibitor of N-terminal nucleophile (Ntn) hydrolases. Specifically, Enzyme-IN-1 inhibits the chymotrypsin-like activity (CT-L) of the 20S proteasome. Enzyme-IN-1 may has potential antiinflammatory properties.
    Enzyme-IN-1
  • HY-150232
    MALT1-IN-11 2812352-99-9 98%
    MALT1-IN-11 (Example 151 in reference Patent) is a MALT1 protease inhibitor (IC50 < 10 nM). MALT1-IN-11 inhibits IL10 secretion with an IC50 of 10-100 nM. MALT1-IN-11 can be used for the research of cancer, autoimmune and inflammatory disorders.
    MALT1-IN-11
  • HY-150501
    Diprovocim-X 3005274-77-8 98.64%
    Diprovocim-X (compound 35) is a potent TLR1/TLR2 (toll-like receptor 1/2) agonist, with EC50 values of 0.14 and 0.75 nM for hTLR1/TLR2 and mTLR1/TLR2, respectively. Diprovocim-X is a potent adjuvant in vivo in mice, and serves to stimulate the adaptive immune response.
    Diprovocim-X
  • HY-150729
    ODN 1982 207623-15-2
    ODN 1982 is a unmethylated oligodeoxyribonucleotide (ODN) with no CpG motif, can be used to prepare DNA vaccines. ODN 1982 inhibits R-848 signaling. ODN 1982 sequence: 5’-tccaggacttctctcaggtt-3’.
    ODN 1982
  • HY-150739
    ODN 21158 1964506-31-7 98.16%
    ODN 21158 is a potent G-modified TLR3 and TLR9 inhibitor. ODN 21158 shows no cytotoxic. ODN 21158 inhibits IFN-α secretion in a dose dependent manner.
    ODN 21158
Cat. No. Product Name / Synonyms Application Reactivity