2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P990992
    Efzilonkofusp alfa 2922216-50-8 98%
    Efzilonkofusp alfa is a bispecific Fc fusion protein. Efzilonkofusp alfa is formed by fusing the N-terminal extracellular domain of human CD80 (B7.1) with the Fc fragment of human immunoglobulin G4 (IgG4), and is linked to an interleukin-2 variant (IL-2v) as the C-terminal part. Efzilonkofusp alfa exhibits potential immunostimulatory, immune checkpoint inhibitory, and antitumor activities.
    Efzilonkofusp alfa
  • HY-P990997
    Gacovetug 2935485-57-5 98%
    HY-P990997 is an F4+ enterotoxigenic Escherichia coli (ETEC) FaeG-targeting (VH-h-CH2-CH3-CHS) dimer type chimeric antibody.
    Gacovetug
  • HY-P991003
    Ingitamig 2839572-09-5 98%
    HY-P991003 is an TNFRSF17/KLRK1-targeting (G1_L-κ)_(G1-scFvkh_L-κ) type bispecific antibody.
    Ingitamig
  • HY-P991032
    Tizetatug 2938864-87-8 99%
    HY-P991032 is an TACSTD2/TROP2-targeting IgG1κ type bispecific antibody, the recommed isotype control is Human IgG1 kappa, Isotype Control (HY-P99001).
    Tizetatug
  • HY-N0326S13
    L-Methionine-d1 74334-17-1
    L-Methionine-d1 is the deuterium labeled L-Methionine (HY-N0326). L-Methionine is an L-isomer of orally active Methionine, an essential amino acid. Methionine is a strong liver antidote that acts as a liver protector. L-Methionine can inhibit cell proliferation and induce cell apoptosis. L-Methionine has antitumor and antioxidant activity.
    L-Methionine-d1
  • HY-W011303R
    Phytosphingosine (Standard) 554-62-1
    Phytosphingosine (Standard) is the analytical standard of Phytosphingosine. This product is intended for research and analytical applications. Phytosphingosine is a phospholipid with anti-inflammatory, antibacterial, and anti-cancer activities, which can induce apoptosis. Phytosphingosine is an immune regulator and can be used in the study of inflammatory skin diseases. Phytosphingosine is also an activator of GPR120 with an IC50 value of 33.4 μM and can be used in the study of type II diabetes[1][2][3][4].
    Phytosphingosine (Standard)
  • HY-W015546R
    β-N-methylamino-L-alanine hydrochloride (Standard) 16012-55-8 98%
    Clenbuterol (Standard) is the analytical standard of Clenbuterol. This product is intended for research and analytical applications. Clenbuterol (NAB-365) is a β2-adrenergic receptor agonist with an EC50 of 31.9 nM. Clenbuterol is a very potent inhibitor of the lipopolysaccharide (LPS)-induced release of TNF-α and IL-1β. Clenbuterol can inhibit the inflammatory process. Clenbuterol is a bronchodilator.
    β-N-methylamino-L-alanine hydrochloride (Standard)
  • HY-W1126955
    Enlicitide (decanoate) 2861205-06-1 98%
    Enlicitide (MK-0616) decanoate is an orally active macrocyclic peptide PCSK9 inhibitor. Enlicitide decanoate binds to PCSK9, blocks its interaction with low-density lipoprotein receptor (LDLR), and enhances hepatic clearance of LDL-C. Enlicitide decanoate reduces atherogenic lipoproteins, including non-HDL cholesterol, apolipoprotein B, and lipoprotein (a). Enlicitide decanoate is applicable to research related to hypercholesterolemia, heterozygous familial hypercholesterolemia, and atherosclerotic cardiovascular disease.
    Enlicitide (decanoate)
  • HY-P1089
    Cytochrome c-pigeon (88-104) 86579-06-8 98%
    Cytochrome c-pigeon (88-104) (PCC 88-104) has full stimulatory activity for pigeon cytochrome c-primed T cells from B10.A mice. The I-Ek-restricted T cell response to Cytochrome c pigeon (pcyt c) is specific for the COOH-terminal sequence 88-104.
    Cytochrome c-pigeon (88-104)
  • HY-P2521
    NS2 (114-121), Influenza 184763-32-4 98%
    NS2 (114-121), Influenza, the 114-121 fragment of influenza nonstructural protein 2 (NS2), is a influenza-derived epitope. NS2 (114-121), Influenza can be used for the research of CD8+ cytotoxic T lymphocyte (CTL) in antiviral immune responses.
    NS2 (114-121), Influenza
  • HY-10046S
    Plerixafor-d4 1246819-87-3 98%
    Plerixafor-d4 is the deuterium labeled Plerixafor. Plerixafor (AMD 3100) is a selective CXCR4 antagonist with an IC50 of 44 nM. Plerixafor, an immunostimulant and a hematopoietic stem cell (HSC) mobilizer, is an allosteric agonist of CXCR7. Plerixafor inhibits HIV-1 and HIV-2 replication with an EC50 of 1-10 nM.
    Plerixafor-d4
  • HY-15388S
    Tazarotene-d8 98%
    Tazarotene-d8 is the deuterium labeled Tazarotene. Tazarotene (AGN 190168) is a selective retinoic acid receptor (RAR) agonist for the treatment of plaque psoriasis and acne vulgaris.
    Tazarotene-d8
  • HY-15762S
    Valdecoxib-d3 1219794-90-7 98%
    Valdecoxib-d3 is the deuterium labeled Valdecoxib. Valdecoxib is a highly potent and selective inhibitor of COX-2, with IC50s of 5 nM and 140 μM for COX-2 and COX-1, respeceively. Valdecoxib can be used in the research of arthritis and pain.
    Valdecoxib-d3
  • HY-17043S
    Loratadine-d4 381727-27-1 98%
    Loratadine-d4 is the deuterium labeled Loratadine. Loratadine (SCH-29851) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Loratadine has anti-dengue-virus (DENV) activity. Loratadine can inhibit immunologic release of inflammatory mediators.
    Loratadine-d4
  • HY-A0178S
    Isothipendyl-d6 1330265-10-5 98%
    Isothipendyl-d6 is the deuterium labeled (7E,9E)-β-Ionylideneacetaldehyde.
    Isothipendyl-d6
  • HY-B0091S
    Adapalene-d3 1276433-89-6 98%
    Adapalene-d3 is the deuterium labeled Adapalene. Adapalene (CD271), a third-generation synthetic retinoid, is widely used for the research of acne. Adapalene is a potent RAR agonist, with AC50s of 2.3 nM, 9.3 nM, and 22 nM for RARβ, RARγ, RARα, respectively. Adapalene also inhibits the enzymatic activity of GOT1 in a non-competitive manner. Adapalene exhibits anti-tumor activity.
    Adapalene-d3
  • HY-B0310S
    Nizatidine-d3 1246833-99-7 98.80%
    Nizatidine-d3 is the deuterium labeled Nizatidine. Nizatidine is a potent and orally active histamine H2 receptor antagonist, can be used for the research of stomach?and?intestines ulcers. Nizatidine works by decreasing the secretion of gastric?acid the stomach makes and prevent ulcers from coming back after they have healed in animal models.
    Nizatidine-d3
  • HY-B0339S
    Primidone-d5 73738-06-4 99.00%
    Primidone-d5 is the deuterium labeled Primidone. Primidone is the orally active inhibitor for TRPM3 (IC50 = 0.6 μM), RIP kinase and voltage-gated sodium channel, and the antagonist for GABA receptor. Primidone can be used as the analgesic and anticonvulsant agent.
    Primidone-d5
  • HY-B0367S
    Lornoxicam-d4 1216527-48-8 98%
    Lornoxicam-d4 is the deuterium labeled Lornoxicam. Lornoxicam (Chlortenoxicam), a COX-1 and COX-2 inhibitor, is a new nonsteroidal anti-inflammatory agent (NSAID).
    Lornoxicam-d4
  • HY-B0539S
    Desloratadine-d4 381727-29-3 98%
    Desloratadine-d4 is the deuterium labeled Desloratadine. Desloratadine (Sch34117) is the orally active major metabolite of the nonsedating H1-antihistamine Loratadine. Desloratadine is a selective H1-receptor antagonist that has anti-allergic and anti-inflammatory activities[1][2].
    Desloratadine-d4
Cat. No. Product Name / Synonyms Application Reactivity