Efzilonkofusp alfa
Efzilonkofusp alfa is a bispecific Fc fusion protein. Efzilonkofusp alfa is formed by fusing the N-terminal extracellular domain of human CD80 (B7.1) with the Fc fragment of human immunoglobulin G4 (IgG4), and is linked to an interleukin-2 variant (IL-2v) as the C-terminal part. Efzilonkofusp alfa exhibits potential immunostimulatory, immune checkpoint inhibitory, and antitumor activities.
For research use only. We do not sell to patients.
- CAS No.: 2922216-50-8
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
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Help & FAQs
Biological Activity
Fusion - [CD80 (B7-1, CD28LG1)]2 - IGHG4 Fc (Fragment constant) - [IL2 (interleukin 2, IL-2) (Pr21-153)]2
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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FPIA_[PROTEIN_PROTEIN]2-FC-[PROTEIN]2
ELISA, FACS, Functional assay
Chemical Information
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CAS No. 2922216-50-8
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SMILES
[Efzilonkofusp alfa]
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Synonyms
GI-102
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Efzilonkofusp alfa Related Classifications
HY-P990992 Related Classifications
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