2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-156340
    Anti-inflammatory agent 58 3032851-09-2 98%
    Anti-inflammatory agent 58 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits IL-1β with an IC50 of 1.08 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation.
    Anti-inflammatory agent 58
  • HY-156342
    Anti-inflammatory agent 59 3032851-11-6 98%
    Anti-inflammatory agent 59 is an anti-inflammatory agent. Anti-inflammatory agent 58 inhibits IL-1β with an IC50 of 2.28 μM. Anti-inflammatory agent 58 decreases pro-inflammatory gene expression, protein secretion, and NF-κB phosphorylation.
    Anti-inflammatory agent 59
  • HY-156360
    Xanthine oxidase-IN-12 3041062-80-7 98%
    Xanthine oxidase-IN-12 (Compound 11) is a xanthine oxidase (XO) inhibitor with an IC50 of 91 nM. Xanthine oxidase-IN-12 also has antioxidant activity and reduces intracellular ROS.
    Xanthine oxidase-IN-12
  • HY-156367
    RIPK1-IN-16 2561431-77-2 98%
    RIPK1-IN-16 is an orally active and potent inhibitor of RIPK1. RIPK1-IN-16 inhibits excessive inflammation by blocking RIPK1-mediated necroptosis in vivo. RIPK1-IN-16 protects mouse from TNF-induced systemic inflammatory response syndrome and sepsis.
    RIPK1-IN-16
  • HY-156368
    RIPK3-IN-4 2304617-58-9 98%
    RIPK3-IN-4 (Compound 42) is a RIPK3 inhibitor. RIPK3-IN-4 inhibits HK-2 cell damage, necroptosis and inflammatory responses. RIPK3-IN-4 reduces Cisplatin (HY-17394)- and I/R-induced kidney damage, inflammatory response and necroptosis in acute kidney injury.
    RIPK3-IN-4
  • HY-156398
    Anti-inflammatory agent 60 98%
    Anti-inflammatory agent 60(compound 21) inhibitsnitric oxide production, with anIC50value of 12.95 μM.Anti-inflammatory agent 60reducesiNOS,phosphorylated p65, andβ-cateninexpression in a concentration-dependent manner.
    Anti-inflammatory agent 60
  • HY-156408
    Spns2-IN-1 3049214-20-9 98%
    Spns2-IN-1 is a potent inhibitor of Spns2-dependent S1P transport (Spns2), with IC50 of 1.4±0.3 μM that plays an important role in immune response.
    Spns2-IN-1
  • HY-156415
    NLRP3 agonist 2 3049344-69-3 98%
    NLRP3 agonist 2 (compound 22) is a orally active NLRP3 agonist.NLRP3 agonist 2 activates Caspase-1 in THP1 cells.
    NLRP3 agonist 2
  • HY-156425
    NOX2-IN-2 2648709-79-7 98%
    NOX2-IN-2 (compound 33) is a potent NOX2 inhibitor targeting the p47phox-p22phox protein-protein interaction with a Ki of 0.24 μM. NOX2-IN-2 inhibits ROS production derived from NOX2 in cells.
    NOX2-IN-2
  • HY-156458
    SR-29065 98%
    SR-29065 is a selective REV-ERBα agonist, can be used for autoimmune disorders research.
    SR-29065
  • HY-156469
    NLRP3-IN-22 1193329-98-4 98%
    NLRP3-IN-22 (Compound II-4) is a NLRP3 inhibitor (inhibition rate: 67% at 10 μM)
    NLRP3-IN-22
  • HY-156534
    5-HT2A&5-HT2C agonist-1 1640-02-4 98%
    5-HT2A&5-HT2C agonist-1 (Example 2) is a 5-HT2A & 5-HT2C agonist, with IC50s of 196 nM and 0.9 nM respectively. 5-HT2A&5-HT2C agonist-1 can be used for research of depression, alcoholism, tobacco and cocaine addiction, inflammation, cluster headache, PTSD, seizure disorders and other CNS disorders.
    5-HT2A&5-HT2C agonist-1
  • HY-156535
    JAK kinase-IN-1 2698389-43-2 98%
    JAK kinase-IN-1 (Example 1) is a JAK inhibitor. JAK kinase-IN-1 inhibits TYK2, JAK1, JAK2 and JAK3 with IC50 values of 4.2 nM, 32 nM, 27 nM, 3473 nM respectively.
    JAK kinase-IN-1
  • HY-156536
    RXFP1 receptor agonist-1 2924619-64-5 98%
    RXFP1 receptor agonist-1 (Example 2 peak2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-1 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 300 nM.
    RXFP1 receptor agonist-1
  • HY-156537
    RXFP1 receptor agonist-2 2924460-54-6 98%
    RXFP1 receptor agonist-2 (Example 124) is a RXFP1 receptor agonist. RXFP1 receptor agonist-2 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1 nM.
    RXFP1 receptor agonist-2
  • HY-156538
    RXFP1 receptor agonist-3 2924767-53-1 98%
    RXFP1 receptor agonist-3 (Example 223) is a RXFP1 receptor agonist. RXFP1 receptor agonist-3 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 2 nM.
    RXFP1 receptor agonist-3
  • HY-156539
    RXFP1 receptor agonist-4 2941376-76-5 98%
    RXFP1 receptor agonist-4 (Example 268) is a RXFP1 receptor agonist. RXFP1 receptor agonist-4 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 4.9 nM.
    RXFP1 receptor agonist-4
  • HY-156540
    RXFP1 receptor agonist-5 2941385-36-8 98%
    RXFP1 receptor agonist-5 (Example 98) is a RXFP1 receptor agonist. RXFP1 receptor agonist-5 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 1.3 nM.
    RXFP1 receptor agonist-5
  • HY-156541
    RXFP1 receptor agonist-6 2941346-85-4 98%
    RXFP1 receptor agonist-6 (Example 7) is a RXFP1 receptor agonist. RXFP1 receptor agonist-6 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 12 nM.
    RXFP1 receptor agonist-6
  • HY-156542
    RXFP1 receptor agonist-7 2941484-13-3 98%
    RXFP1 receptor agonist-7 (Example 2) is a RXFP1 receptor agonist. RXFP1 receptor agonist-7 stimulates cAMP production in HEK293 cells stably expressing human RXFP1, with an EC50 value of 4.2 nM.
    RXFP1 receptor agonist-7
Cat. No. Product Name / Synonyms Application Reactivity