2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N8593R
    Undecane (Standard) 1120-21-4 98%
    Undecane (Standard) is an analytical standard of Undecane (HY-N8593).Undecane is a potent cAMP agonist with anti-allergic and anti-inflammatory activities. Undecane inhibits degranulation and the secretion of histamine and TNF-α. Undecane reverses the increased levels of p38 phosphorylation, NF-κB transcriptional activity and target cytokine/chemokine genes, including thymus and activation-regulated chemokine (TARC), macrophage-derived chemokine (MDC) and interleukin-8 (IL-8). Undecane can be used for the study of skin inflammatory disorders, such as atopic dermatitis.
    Undecane (Standard)
  • HY-N9086A
    (rac)-Poriol 70460-58-1 98%
    (rac)-Poriol (5,7,4'-Trihydroxy-6-methylflavanone) exhibits antioxidant activity, and scavenges free radical DPPH with an IC50 of 0.18 µg/mL. (rac)-Poriol inhibits the LPS (HY-D1056)-induced NO generation in RAW264.7 (98.35% inhibition rate at 10 μM), and exhibits anti-inflammatory activity. (rac)-Poriol exhibits good binding affinity with iNOS, COX-1, COX-2, TNF-α, and IL-1β.
    (rac)-Poriol
  • HY-N9388R
    Andrograpanin (Standard) 82209-74-3
    Andrograpanin (Standard) is the analytical standard of Andrograpanin. This product is intended for research and analytical applications. Andrograpanin, a bioactive compound from Andrographis paniculata, exhibits anti-inflammatory and anti-infectious properties.
    Andrograpanin (Standard)
  • HY-N9508R
    Perilla ketone (Standard) 553-84-4 98%
    Perilla ketone is a naturally occurring xenobiotic compound. Perilla ketone is activated by pulmonary P450 cytochrome enzymes in the lung, resulting in severe pulmonary damage and development of diffuse pulmonary edema.
    Perilla ketone (Standard)
  • HY-N9945R
    3-Oxo-7-hydroxychol-4-enoic acid (Standard) 14772-95-3 98%
    3-Oxo-7-hydroxychol-4-enoic acid is an endogenous metabolite. 3-Oxo-7-hydroxychol-4-enoic acid may be an important indicator of a poor prognosis in hepatobiliary disease.
    3-Oxo-7-hydroxychol-4-enoic acid (Standard)
  • HY-P0063A
    Copper tripeptide acetate 300801-03-0 98%
    Copper tripeptide (GHK-Cu) acetate is a tripeptide. During wound healing, Copper tripeptide acetate may be freed from existing extracellular proteins via proteolysis and serves as a chemoattractant for inflammatory and endothelial cells. Copper tripeptide acetate has been shown to increase messenger RNA production for collagen, elastin, proteoglycans, and glycosaminoglycans in fibroblasts. Copper tripeptide acetate is a natural modulator of multiple cllular pathways in skin regeneration.
    Copper tripeptide acetate
  • HY-P0119S
    Lixisenatide (Leu-13C6,15N) TFA 98%
    Lixisenatide (Leu-13C6,15N) TFA is the 13C- and 15N-labeled Lixisenatide (HY-P0119). Lixisenatide is a glucagon-like peptide-1 (GLP-1) receptor agonist. Lixisenatide inhibits the inflammatory response through down regulation of pro-inflammatory cytokines, and suppresses of the Akt-MEK1/2 signaling pathway. Lixisenatide can inhibit oxidative stress, mitochondrial dysfunction and apoptosis. Lixisenatide can be used for the researches of inflammation, metabolic disease, neurological disease and cardiovascular disease, such as rheumatoid arthritis, diabetes, Alzheimer's disease and atherosclerosis.
    Lixisenatide (Leu-13C6,15N) TFA
  • HY-P10718
    IMG-2005 1229954-79-3 98%
    IMG-2005 is a TLR signaling pathway inhibitor. IMG-2005 mimics the Toll/interleukin-1 receptor (TIR) domain of MyD88, thereby preventing its homodimerization, which causes damage to tracheal epithelial cells and triggers pulmonary immune diseases.
    IMG-2005
  • HY-P11545
    2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A 164028-89-1
    2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A (Compound 33) is a Cyclosporine derivative. 2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A shows an IC50 of 0.11 μg/mL in the mixed lymphocyte reaction.
    2-[O-(2-Azidoethyl)-D-serine]-cyclosporin A
  • HY-P1242B
    NEP(1-40), N-terminal uncapped 98.22%
    NEP(1-40), N-terminal uncapped is a NEP(1-40) (HY-P1242) analog without the acetylation modification at the N-terminal. NEP(1-40) is a Nogo-66 receptor (NgR) antagonist peptide.
    NEP(1-40), N-terminal uncapped
  • HY-P1624S
    Teduglutide-Ala(13C3,15N) sodium 98%
    Teduglutide-Ala(13C3,15N) (ALX-0600-Ala(13C3,15N)) sodium is the 13C- and 15N-labeled Teduglutide (HY-P1624). Teduglutide (ALX-0600) is an analog of human glucagon like peptide-2 (GLP-2). Teduglutide can activate the expression of nuclear receptor subfamily 4 group a member 1 (NR4a1)/nur77 and intestinal FXR signaling in human hepatic stellate cells, thereby improving liver inflammation and fibrosis in mice with sclerosing cholangitis. Teduglutide can alleviate intestinal dysfunction in mice, improve lung injury, alleviate obesity related neuroinflammation and cell apoptosis.
    Teduglutide-Ala(13C3,15N) sodium
  • HY-P3449A
    Dazdotuftide TFA 2522933-45-3 98%
    Dazdotuftide (TFA) (TRS01 (TFA)) is an active compound and can be used as an immunomodulator.
    Dazdotuftide TFA
  • HY-P3502B
    Zilucoplan (PEG2) 98%
    Zilucoplan (PEG2) is a Zilucoplan (HY-P3502) derivative, where the linker section replaces PEG24 by PEG2. Zilucoplan is a potent complement component 5 (C5) inhibitor.
    Zilucoplan (PEG2)
  • HY-P99147
    Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)
    Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) is an Armenian Hamster-derived IgG antibody inhibitor, targeting to mouse TCR V gamma 2. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) reacts with an epitope on the delta chain of the mouse Vγ2 TCR (V gamma 2 T cell receptor). Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can deplete γδ T cell. Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6) can be used for the researches of infection and immunology, such as herpes simplex virus-1 (HSV-1) infection.
    Anti-Mouse TCR V gamma 2 Antibody (UC3-10A6)
  • HY-P99820
    Ranevetmab 1632282-27-9
    Ranevetmab (NV-01) is a caninised anti-NGF monoclonal antibody (mAb). Ranevetmab can alleviate pain, and is used for the research of degenerative joint disease (DJD) pain.
    Ranevetmab
  • HY-U00005
    AD 0261 145600-69-7 98%
    AD 0261 is a radical scavenger which displays strong inhibitory action on the generation of lipid peroxides and superoxide anions.
    AD 0261
  • HY-U00011
    Temarotene 75078-91-0 98%
    Temarotene is an orally administered, particular arotinoid.
    Temarotene
  • HY-U00042
    SKF96067 115607-61-9 98%
    SKF96067 is a reversible inhibitor of the gastric H+/K+-ATPase.
    SKF96067
  • HY-U00043
    Triamcinolone Benetonide 31002-79-6 98%
    Triamcinolone benetonide is a synthetic glucocorticoid corticosteroid with anti-inflammatory activity.
    Triamcinolone Benetonide
  • HY-U00067
    Ambutonium bromide 115-51-5 98%
    Ambutonium bromide is an acetylcholine antagonist.
    Ambutonium bromide
Cat. No. Product Name / Synonyms Application Reactivity