2. Immunology/Inflammation
  3. Complement System
  4. Zilucoplan (PEG2)

Zilucoplan (PEG2) is a Zilucoplan (HY-P3502) derivative, where the linker section replaces PEG24 by PEG2. Zilucoplan is a potent complement component 5 (C5) inhibitor.

For research use only. We do not sell to patients.

Zilucoplan (PEG2)

Zilucoplan (PEG2) Chemical Structure

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Other Forms of Zilucoplan (PEG2):

Zilucoplan (PEG2) Related Antibodies

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Description

Zilucoplan (PEG2) is a Zilucoplan (HY-P3502) derivative, where the linker section replaces PEG24 by PEG2. Zilucoplan is a potent complement component 5 (C5) inhibitor[1].

Molecular Weight

2593.02

Formula

C128H190N24O33
SMILES

CCCCCCCCCCCCCCCC(N[C@H](C(O)=O)CCC(NCCOCCOCCC(NCCCC[C@H](NC([C@@H](NC([C@@H]1CCCN1C([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N(C([C@@H]2CC(NCCCC[C@H](NC(C)=O)C(N[C@@H](C(C)C)C(N[C@@H](CCC(O)=O)C(N[C@@H](CCCNC(N)=N)C(N[C@@H](CC3=CC=CC=C3)C(N2)=O)=O)=O)=O)=O)=O)=O)C)CC(O)=O)=O)C(C)(C)C)=O)CC4=CC=C(O)C=C4)=O)CC5=CNC6=C5C=CC=N6)=O)CCC(O)=O)=O)CC7=CC=C(O)C=C7)=O)=O)C8CCCCC8)=O)C(O)=O)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (38.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.3857 mL 1.9283 mL 3.8565 mL
5 mM 0.0771 mL 0.3857 mL 0.7713 mL
View the Complete Stock Solution Preparation Table

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.3857 mL 1.9283 mL 3.8565 mL 9.6413 mL
5 mM 0.0771 mL 0.3857 mL 0.7713 mL 1.9283 mL
10 mM 0.0386 mL 0.1928 mL 0.3857 mL 0.9641 mL
15 mM 0.0257 mL 0.1286 mL 0.2571 mL 0.6428 mL
20 mM 0.0193 mL 0.0964 mL 0.1928 mL 0.4821 mL
25 mM 0.0154 mL 0.0771 mL 0.1543 mL 0.3857 mL
30 mM 0.0129 mL 0.0643 mL 0.1286 mL 0.3214 mL
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Zilucoplan (PEG2) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zilucoplan (PEG2)Complement SystemZilucoplan derivativePEG2complement component 5Inhibitorinhibitorinhibit

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