2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Art. -Nr. Produktname CAS. Nr. Reinheit Chemische Struktur
  • HY-13710AR
    Dimethindene maleate (Standard) 3614-69-5 98%
    Dimethindene (maleate) (Standard) is the analytical standard of Dimethindene (maleate). This product is intended for research and analytical applications. Dimethindene maleate is a selective histamine H1 antagonist with antihistamine effects. Dimethindene maleate can be used for the research of hypersensitivity reactions.
    Dimethindene maleate (Standard)
  • HY-137222S
    4',5-Dihydroxy Diclofenac-13C6 1309283-30-4 98%
    4',5-Dihydroxy Diclofenac-13C6 is a deuterated derivative of Diclofenac (HY-15036). Diclofenac is a potent COX inhibitor with anti-inflammatory activity.
    4',5-Dihydroxy Diclofenac-13C6
  • HY-137298A
    LYS006 hydrochloride 2619563-79-8 98%
    LYS006 hydrochloride is a potent inhibitor of leukotriene A4 hydrolase (LTA4H) extracted from patent WO2015092740A1, example 29, has an IC50 of 2 nM. LYS006 hydrochloride can be used for the research of inflammatory and autoimmune disorders.
    LYS006 hydrochloride
  • HY-137312A
    Carbuterol hydrochloride 34866-46-1 98%
    Carbuterol (SKF 40383-A) hydrochloride is a selective β2-adrenergic receptor agonist that primarily targets bronchial smooth muscle, exhibiting significant bronchodilatory and anti-allergic activity. Carbuterol hydrochloride can directly inhibit the immunologically induced release of histamine and slow-reacting substance of anaphylaxis (SRS-A), thereby alleviating allergic responses. In addition, it exerts mild β1-mediated cardiac stimulation and is applicable to studies related to respiratory and immune-related diseases such as asthma and allergic disorders.
    Carbuterol hydrochloride
  • HY-137378A
    8-Br-PET-cGMP 144510-04-3 98%
    8-Br-PET-cGMP is an agonist of cGMP-dependent protein kinase type I (cGKI). 8-Br-PET-cGMP promotes the dimerization of cGKI and activates its catalytic activity by binding to the regulatory domain of cGKI. 8-Br-PET-cGMP can be used to study the role of cGMP signaling pathways in cell growth, vasodilation, and smooth muscle cell function.
    8-Br-PET-cGMP
  • HY-13756S2
    Tacrolimus-d3 98%
    Tacrolimus-d3 (FK506-d3) is deuterium labeled Tacrolimus. Tacrolimus (FK506), a macrocyclic lactone, binds to FK506 binding protein (FKBP) to form a complex. Tacrolimus inhibits calcineurin phosphatase, which inhibits T-lymphocyte signal transduction and IL-2 transcription. Immunosuppressive properties.
    Tacrolimus-d3
  • HY-137941R
    Roxatidine (Standard) 78273-80-0
    Roxatidine (Standard) is the analytical standard of Roxatidine. This product is intended for research and analytical applications. Roxatidine is an active metabolite of Roxatidine acetate hydrochloride, is a histamine H2-receptor antagonist. Roxatidine, an anti-ulcer agent, suppresses histamine release (thus inhibiting proton secretion) and inhibits the production of VEGF-1, an important marker of inflammation and angiogenesis. Anti-allergic inflammatory effect.
    Roxatidine (Standard)
  • HY-13911AR
    Hydroxyfasudil hydrochloride (Standard) 155558-32-0
    Hydroxyfasudil (hydrochloride) (Standard) is the analytical standard of Hydroxyfasudil (hydrochloride). This product is intended for research and analytical applications. Hydroxyfasudil hydrochloride is a ROCK inhibitor, with IC50s of 0.73 and 0.72 μM for ROCK1 and ROCK2, respectively.
    Hydroxyfasudil hydrochloride (Standard)
  • HY-139352R
    Betamethasone 21-valerate (Standard) 2240-28-0
    Betamethasone 21-valerate (Standard) is the analytical standard of Betamethasone 21-valerate. This product is intended for research and analytical applications. Betamethasone 21-valerate is a corticosteroid ester with anti-inflammatory activities.
    Betamethasone 21-valerate (Standard)
  • HY-141432G
    NX-1607 (GMP) 2573775-59-2 98%
    NX-1607 (Cbl-b-IN-3) (GMP) is a GMP-grade NX-1607 (HY-141432). GMP-grade small molecules can be used as adjuvant agents in cell therapy. NX-1607 (GMP) enhances antigen recall, reduces T cell exhaustion and increases cytokine production. NX-1607 is an inhibitor of Cbl-b (an E3 enzyme).
    NX-1607 (GMP)
  • HY-142123R
    Fluocortolone (Standard) 152-97-6
    Fluocortolone (Standard) is the analytical standard of Fluocortolone. This product is intended for research and analytical applications. Fluocortolone is an orally active anti-inflammatory agent that effectively reduces plasma fibrinogen levels. Fluocortolone inhibits Mycobacterium butyricum-induced foot edema in a rat model of adjuvanted joint inflammation (3-12 mg/kg).
    Fluocortolone (Standard)
  • HY-14277AR
    Levocabastine hydrochloride (Standard) 79547-78-7
    Levocabastine (hydrochloride) (Standard) is the analytical standard of Levocabastine (hydrochloride). This product is intended for research and analytical applications. Levocabastine (R 50547) hydrochloride is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine hydrochloride can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC).
    Levocabastine hydrochloride (Standard)
  • HY-14300S2
    Vilanterol-d12 98%
    Vilanterol-d12 (GW642444-d12) is deuterium labeled Vilanterol. Vilanterol (GW642444) is a long-acting β2-adrenoceptor (β2-AR) agonist with 24 h activity. The pEC50s for β2-AR,β1-AR and β3-AR is 10.37±0.05, 6.98±0.03 and 7.36±0.03, respectively.
    Vilanterol-d12
  • HY-14397S2
    Indometacin-d7 98%
    Indometacin-d7 is deuterated labeled Indomethacin (HY-14397). Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research.
    Indometacin-d7
  • HY-14397S3
    Indomethacin-13C6 98%
    Indomethacin-13C6 (Indometacin-13C6) is 13C labeled Indomethacin. Indomethacin (Indometacin) is a potent, orally active COX1/2 inhibitor with IC50 values of 18 nM and 26 nM for COX-1 and COX-2, respectively. Indomethacin has anticancer activity and anti-infective activity. Indomethacin can be used for cancer, inflammation and viral infection research.
    Indomethacin-13C6
  • HY-14447S1
    Bilastine-d4 2747918-37-0 98%
    Bilastine-d4 is deuterium labeled Bilastine. Bilastine is an oral histamine H1-receptor antagonist. Bilastine can be used for allergic rhinitis and urticaria studies, and it also improves diabetic nephropathy in mice, showing safety for the central nervous system.
    Bilastine-d4
  • HY-145193A
    (R)-MrgprX2 antagonist-3 2642174-20-5 98%
    (R)-MrgprX2 antagonist-3 (compound E118) is an MrgprX2 antagonist extracted from patent WO2021092240A1, example E118. (R)-MrgprX2 antagonist-3 can be used for the research of inflammatory disorders of the skin.
    (R)-MrgprX2 antagonist-3
  • HY-14519AR
    Methotrexate disodium (Standard) 7413-34-5 98%
    Methotrexate (disodium) (Standard) is the analytical standard of Methotrexate (disodium). This product is intended for research and analytical applications. Methotrexate (Amethopterin) disodium, an antimetabolite and antifolate agent, inhibits the enzyme dihydrofolate reductase, thereby preventing the conversion of folic acid into tetrahydrofolate, and inhibiting DNA synthesis. Methotrexate disodium, also an immunosuppressant and antineoplastic agent, is used for the research of rheumatoid arthritis and a number of different cancers (such as acute lymphoblastic leukemia).
    Methotrexate disodium (Standard)
  • HY-145453R
    Propacetamol (Standard) 66532-85-2
    Propacetamol (Standard) is the analytical standard of Propacetamol (HY-145453). This product is intended for research and analytical applications. Propacetamol is an orally active prodrug of Acetaminophen (HY-66005), which exerts antipyretic and analgesic effects after metabolism. Propacetamol reduces Aspirin (ASA) (HY-14654)-induced elevation of malondialdehyde (MDA) in gastric mucosa and plasma, regulates the levels of gastric mucosal glutathione (GSH and GSSG) to maintain cellular antioxidant defense, and increases gastric mucosal uric acid (UA) levels. Propacetamol exerts a dose-dependent protective effect against ASA-induced gastric mucosal damage in rats. Propacetamol can be used for the study of gastric mucosal injury by interfering with oxidative stress.
    Propacetamol (Standard)
  • HY-14655S1
    Sulfasalazine-d3,15N 98%
    Sulfasalazine-d3,15N is 15N and deuterated labeled Sulfasalazine (HY-14655). Sulfasalazine (NSC 667219) is an anti-rheumatic agent for the research of rheumatoid arthritis and ulcerative colitis. Sulfasalazine can suppress NF-κB activity. Sulfasalazine is a type 1 ferroptosis inducer.
    Sulfasalazine-d3,15N
Art. -Nr. Produktname / Synonyms Application Reactivity