2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W142456
    (S)-1-Benzyl-5-carboxy-2-pyrrolidinone 7535-59-3 98%
    (S)-1-Benzyl-5-carboxy-2-pyrrolidinone (N-Benzyl-L-pyroglutamic acid) is an orally active H+/K+-ATPase inhibitor. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone reduces free acidity and total acidity in gastric juice. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone decreases ulcer formation in pylorus-ligated rats. (S)-1-Benzyl-5-carboxy-2-pyrrolidinone can be used for the research of peptic ulcers.
    (S)-1-Benzyl-5-carboxy-2-pyrrolidinone
  • HY-W142457
    Dihydromyrcenol 18479-58-8 98%
    Dihydromyrcenol is an orally active flavor ingredient and Antifungal agent. Dihydromyrcenol acts as a toxicant. Dihydromyrcenol induces phototoxicity-related growth inhibition in Bakers' Yeast. In pregnant rats, Dihydromyrcenol causes threshold maternal toxicity by reducing feed consumption and body weight gain, and also induces threshold developmental toxicity by decreasing fetal body weight, inhibiting ossification of metatarsal bones in the hind paws, increasing the number of extra thoracic vertebrae ribs, and altering vertebral counts.
    Dihydromyrcenol
  • HY-W162983
    3,4-Diphenyl-5H-furan-2-one 5635-16-5 98%
    3,4-Diphenyl-5H-furan-2-one is a natural compound isolated from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. 3,4-Diphenyl-5H-furan-2-one is a derivative of 2,3-diphenyltetrahydrofuran (DPTF), which is a COX-2 inhibitor. 3,4-Diphenyl-5H-furan-2-one can be used as a lead compound for inflammation and pain.
    3,4-Diphenyl-5H-furan-2-one
  • HY-W173309
    Lonazolac 53808-88-1 99.59%
    Lonazolac is a non-steroidal antirheumatic agent. Anti-inflammatory effects .
    Lonazolac
  • HY-W176576
    Falimint 553-20-8 99.86%
    Falimint is an antipyretic and analgesic compound.
    Falimint
  • HY-W179151
    N-Octanoyl dopamine 105026-81-1 98%
    N-Octanoyl dopamine is superior to dopamine in protecting graft contractile function when administered to the heart transplant recipients from brain-dead donors. N-Octanoyl dopamine inhibits cytokine production in activated T-cells and diminishes MHC-class-II expression as well as adhesion molecules in IFNγ-stimulated endothelial cells.
    N-Octanoyl dopamine
  • HY-W237498
    Urease-IN-17 4322-58-1 98%
    Urease-IN-17 (9) is a urease inhibitor, with an IC50 of 84 μM.
    Urease-IN-17
  • HY-W268942
    4-Nitrosodiphenylamine 156-10-5 98.34%
    4-Nitrosodiphenylamine shows great antibacterial activity against Erwinia amylovora, with an EC50 value of 5.715 mg/L.
    4-Nitrosodiphenylamine
  • HY-W273493
    4-Nitrochalcone 1222-98-6 98%
    4-Nitrochalcone (2-(4-Nitrobenzylidene)acetophenone) inhibits the proteasome, inhibits NF-κB activity induced by TNFα.
    4-Nitrochalcone
  • HY-W276446
    1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol 968-63-8 98%
    1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is an anticholinergic agent. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol has the potential for the research of bronchial asthma. 1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    1,1-Diphenyl-4-(pyrrolidin-1-yl)but-2-yn-1-ol
  • HY-W285243
    3′-Hydroxyflavanone 92496-65-6 98%
    3′-Hydroxyflavanone is a cyclized flavanone. 3′-Hydroxyflavanone induces apoptosis in HeLa cells. 3′-Hydroxyflavanone possesses antitumor activity.
    3′-Hydroxyflavanone
  • HY-W286614
    RSK2-IN-4 62001-32-5 98%
    RSK2-IN-4 (Compound 10) is a RSK2 inhibitor, with an inhibition rate of 13.73% on RSK2 activity at 10 μM. RSK2-IN-4 binds to the ATP-binding site of RSK2 in the NTKD (N-terminal kinase domain), with the electron-donating group at the 4-position of the phenyl ring being the key determinant for its inhibitory activity .
    RSK2-IN-4
  • HY-W288025
    ALXR-agonist-6 325850-26-8 98%
    ALXR-agonist-6 (compound 36) is an ALXR agonist with the EC50 values of >10 μM for Ca2+ flux in CHO recombinant cells co-expressing hFPRL1.
    ALXR-agonist-6
  • HY-W335896
    4-(2-Octylamino)diphenylamine 15233-47-3 98%
    4-(2-Octylamino)diphenylamine is an aromatic amine antioxidant, which is toxic to V. fischeri with an IC50 value of 0.68 mg/mL. 4-(2-Octylamino)diphenylamine induces skin sensitization and contact dermatitis in a local lymph node assay in mice. 4-(2-Octylamino)diphenylamine can be used as an additive in rubber.
    4-(2-Octylamino)diphenylamine
  • HY-W347202
    N-Caffeoyl serotonin 928765-97-3 98%
    N-Caffeoyl serotonin is a COX-2 inhibitor, with IC50 and Kᵢ values of 42.5 μM and 65.5 μM against COX-2, respectively. N-Caffeoyl serotonin exhibits weak inhibitory activity against BACE1, with an IC50 > 400 μM. N-Caffeoyl serotonin has free radical scavenging activity. N-Caffeoyl serotonin can be used in the research of allergic diseases and Alzheimer's disease.
    N-Caffeoyl serotonin
  • HY-W354556
    3-Hydroxyproline 567-36-2
    3-Hydroxyproline is a non-glycosyl microbial α-glucosidase inhibitor. 3-Hydroxyproline is used in the research of diabetes (type 2 diabetes/non-insulin-dependent diabetes mellitus).
    3-Hydroxyproline
  • HY-W396889
    (R)-N-(1-Hydroxypropan-2-yl)palmitamide 142128-47-0
    (R)-N-(1-Hydroxypropan-2-yl)palmitamide (compound 24) is a substrate analog inhibitor of phospholipase A2.
    (R)-N-(1-Hydroxypropan-2-yl)palmitamide
  • HY-W408607
    N-Benzylacetamidine hydrobromide 186545-76-6 98%
    N-Benzylacetamidine (hydrobromide) is a acetamidine compound. N-Benzylacetamidine (hydrobromide) is a selective inducible nitric oxide synthase (iNOS) inhibitor with an IC50 of 0.20 μM.
    N-Benzylacetamidine hydrobromide
  • HY-W408869
    8-iso-13,14-dihydro-15-keto Prostaglandin F2α 191919-02-5 98%
    8-iso-13,14-dihydro-15-keto Prostaglandin F2α is an oxidative metabolite of 8-iso-prostaglandin F2α (HY-113209). 8-iso-13,14-dihydro-15-keto Prostaglandin F2α can be used in the study of oxidative stress-related diseases.
    8-iso-13,14-dihydro-15-keto Prostaglandin F2α
  • HY-W424876
    N-(7H-Purin-6-yl)acetamide 6034-68-0 98%
    N-(7H-Purin-6-yl)acetamide (Compound 25) is a selective adenosine receptor (AdeR) agonist with a Ki value of 0.515 μM for the human adenosine receptor and a Ki value of 2.85 μM for the rat adenosine receptor. N-(7H-Purin-6-yl)acetamide is promising for research of adenosine receptor function, pain perception, inflammatory responses, and renal function.
    N-(7H-Purin-6-yl)acetamide
Cat. No. Product Name / Synonyms Application Reactivity