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  3. Dihydromyrcenol

Dihydromyrcenol is an orally active flavor ingredient and Antifungal agent. Dihydromyrcenol acts as a toxicant. Dihydromyrcenol induces phototoxicity-related growth inhibition in Bakers' Yeast. In pregnant rats, Dihydromyrcenol causes threshold maternal toxicity by reducing feed consumption and body weight gain, and also induces threshold developmental toxicity by decreasing fetal body weight, inhibiting ossification of metatarsal bones in the hind paws, increasing the number of extra thoracic vertebrae ribs, and altering vertebral counts.

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Dihydromyrcenol

Dihydromyrcenol Chemical Structure

CAS No. : 18479-58-8

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Description

Dihydromyrcenol is an orally active flavor ingredient and Antifungal agent. Dihydromyrcenol acts as a toxicant. Dihydromyrcenol induces phototoxicity-related growth inhibition in Bakers' Yeast. In pregnant rats, Dihydromyrcenol causes threshold maternal toxicity by reducing feed consumption and body weight gain, and also induces threshold developmental toxicity by decreasing fetal body weight, inhibiting ossification of metatarsal bones in the hind paws, increasing the number of extra thoracic vertebrae ribs, and altering vertebral counts[1][2].

In Vitro

Dihydromyrcenol (0.1-10%) induces growth inhibition related to phototoxicity in Bakers' Yeast at a concentration of 10%, but exerts no such effect at concentrations of 0.1% or 1.0%[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Dihydromyrcenol (oral administration; single dose) has an acute oral LD50 of 4.1 g/kg in rats, and dose-dependent mortality and specific toxic symptoms are observed at doses ≥2.56 g/kg[1].
The acute dermal LD50 of single-dose Dihydromyrcenol in rabbits is greater than 5.0 g/kg, and mortality and skin irritation are observed at the tested dose[1].
Undiluted dihydromyrcenol (0.5 mL; topical application) induces skin irritation in New Zealand white rabbits, with average erythema and edema scores of 2.0 and 1.6 at 24-72 h, respectively, and partial resolution by day 7[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: unspecified strain[1]
Dosage: 2.56 g/kg; 3.2 g/kg; 4.0 g/kg; 5.0 g/kg
Administration: p.o.; single dose
Result: Recorded mortality of 1/10 rats at 2.56 g/kg, 3/10 rats at 3.2 g/kg, 4/10 rats at 4.0 g/kg, and 8/10 rats at 5.0 g/kg.
Observed toxic signs including lethargy, piloerection, blood on nose, flaccidity, ataxia, and diarrhea.
Determined acute oral LD50 to be 4.1 g/kg.
Animal Model: white New Zealand strain[1]
Dosage: 0.5 mL undiluted
Administration: single 4-hour semi-occlusive application
Result: Observed very slight erythema in 2 animals and very slight edema in 1 animal at 1 hour post-application.
Noted decreased irritation responses between 24 and 48 hours.
Recorded well-defined erythema in 2 animals (1 with very slight edema) and very slight erythema with slight desquamation in 1 animal at 72 hours.
Observed very slight erythema with marked desquamation in 2 animals, very slight edema in 1 animal, and desquamation in 1 animal at 160 hours.\nObserved well-defined erythema and moderate edema in 1 animal, well-defined erythema and slight edema in 2 animals, and very slight reactions in 1 animal at 1 hour post-application.
Noted increased severity at 24 hours, decreased edematous reactions by 48 hours, and only very slight responses remaining in 1 animal after 7 days.
Recorded well-defined erythema in 3 animals and desquamation in 1 animal after 7 days.
Reported average irritation scores of 2.0 for erythema and 1.6 for edema at 24-72 hours.
Molecular Weight

156.27

Formula

C10H20O

CAS No.
SMILES

OC(C)(C)CCCC(C=C)C

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Dihydromyrcenol
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HY-W142457
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