2. Inflammation/Immunology

Inflammation/Immunology

Inflammation/Immunology

Related Products

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The diseases caused by disorders of the immune system fall into two broad categories: immunodeficiency and autoimmunity. Immunotherapy is also often used in the immunosuppressed (such as HIV patients) and people suffering from other immune deficiencies or autoimmune diseases. This includes regulating factors such as IL-2, IL-10, IFN-α. Infection with HIV is characterized not only by development of profound immunodeficiency but also by sustained inflammation and immune activation. Chronic inflammation as a critical driver of immune dysfunction, premature appearance of aging-related diseases, and immune deficiency.

Cat. No. Nombre del producto No. CAS Pureza Estructura química
  • HY-101954AR
    Inarigivir ammonium (Standard) 2172788-92-8 98%
    Inarigivir ammonium (Standard) is the analytical standard of Inarigivir ammonium (HY-101954A). This product is intended for research and analytical applications. Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses.
    Inarigivir ammonium (Standard)
  • HY-102075AR
    TMP778 (Standard) 1422053-04-0 98%
    TMP778 (Standard) is the analytical standard of TMP778 (HY-102075A). This product is intended for research and analytical applications. TMP778 is a potent and selevtive RORγt inverse agonist, with an IC50 of 7 nM in FRET assay.
    TMP778 (Standard)
  • HY-102075BR
    TMP780 (Standard) 1422053-03-9 98%
    TMP780 (Standard) is the analytical standard of TMP780 (HY-102075B). This product is intended for research and analytical applications. TMP780 is an inverse agonist of RORγt with an IC50 of 13 nM. RORγt is a tractable agent target for the treatment of cutaneous inflammatory disorders.
    TMP780 (Standard)
  • HY-103017AR
    JH-X-119-01 (Standard) 2227368-54-7
    JH-X-119-01 (Standard) is the analytical standard of JH-X-119-01 (HY-103017A). This product is intended for research and analytical applications. JH-X-119-01 is a potent and selective interleukin-1 receptor-associated kinases 1 (IRAK1) inhibitor. JH-X-119-01 ameliorates LPS-induced sepsis in mice. JH-X-119-01 inhibits IRAK1 biochemically with an apparent IC50 of 9 nM while exhibiting no inhibition of IRAK4 at concentrations up to 10 μM.
    JH-X-119-01 (Standard)
  • HY-103252S1
    Monomethyl fumarate-d5 1616345-45-9 98%
    Monomethyl fumarate-d5 is deuterium labeled Monomethyl fumarate (HY-103252). Monomethyl fumarate, an active metabolite of Dimethyl fumarate (DMF) (HY-17363), is a potent GPR109A agonist. Monomethyl fumarate has the potential for multiple neuroprotective pathways and other models of retinal disease.
    Monomethyl fumarate-d5
  • HY-103364AR
    C-021 dihydrochloride (Standard) 1784252-84-1 98%
    C-021 (dihydrochloride) (Standard) is the analytical standard of C-021 (dihydrochloride). This product is intended for research and analytical applications. C-021 dihydrochloride is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 dihydrochloride potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 dihydrochloride effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM.
    C-021 dihydrochloride (Standard)
  • HY-103671AR
    IPN60090 dihydrochloride (Standard) 2102101-72-2
    IPN60090 dihydrochloride (Standard) is the analytical standard of IPN60090 dihydrochloride (HY-103671A). This product is intended for research and analytical applications. IPN-60090 dihydrochloride is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC50=31 nM), with no activity observed against GLS-2. IPN-60090 dihydrochloride exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 dihydrochloride can be used for solid tumors research, such as lung and ovarian cancers.
    IPN60090 dihydrochloride (Standard)
  • HY-103698AR
    TLR7/8 agonist 1 dihydrochloride (Standard) 1620278-72-9 98%
    TLR7/8 agonist 1 dihydrochloride (Standard) is the analytical standard of TLR7/8 agonist 1 dihydrochloride (HY-103698A). This product is intended for research and analytical applications. TLR7/8 agonist 1 dihydrochloride is a toll-like receptor TLR7/TLR8 dual-agonistic imidazoquinoline.
    TLR7/8 agonist 1 dihydrochloride (Standard)
  • HY-104026BS
    L-Kynurenine-13C10 sulfate 98%
    L-Kynurenine-13C10 (sulfate) is the 13C labeled L-Kynurenine sulfate. L-Kynurenine sulfate, an aryl hydrocarbon receptor (AHR) agonist that activates AHR-directed, naive T cell polarization to the anti-inflammatory Treg phenotype.
    L-Kynurenine-13C10 sulfate
  • HY-105723AR
    Duazomycin sodium (Standard) 2839447-07-1 98%
    Duazomycin sodium (Standard) is the analytical standard of Duazomycin sodium (HY-105723A). This product is intended for research and analytical applications. Duazomycin (Duazomycin A) sodium is a glutamine antagonist. Duazomycin sodium can significantly enhance the effectiveness of 6-Mercaptopurine (6-MP) (HY-13677) in experimental allergic encephalomyelitis (EAE) without increasing toxicity.
    Duazomycin sodium (Standard)
  • HY-106019CR
    Liarozole dihydrochloride (Standard) 1883548-96-6 98%
    Liarozole (dihydrochloride) (Standard) is the analytical standard of Liarozole (dihydrochloride). This product is intended for research and analytical applications. Liarozole (R75251) dihydrochloride is an imidazole derivative and orally active retinoic acid (RA) metabolism-blocking agent (RAMBA). Liarozole dihydrochloride inhibits the cytochrome P450 (CYP26)-dependent 4-hydroxylation of RA (IC50=7 μM), resulting in increased tissue levels of RA. Liarozole dihydrochloride shows antitumoral properties.
    Liarozole dihydrochloride (Standard)
  • HY-106067AR
    Dazoxiben hydrochloride (Standard) 74226-22-5 98%
    Dazoxiben (hydrochloride) (Standard) is the analytical standard of Dazoxiben (hydrochloride). This product is intended for research and analytical applications. Dazoxiben hydrochloride is a potent and orally active thromboxane (TX) synthase inhibitor.
    Dazoxiben hydrochloride (Standard)
  • HY-106254AR
    Vapendavir diphosphate (Standard) 1198151-75-5 98%
    Vapendavir diphosphate (Standard) is the analytical standard of Vapendavir diphosphate (HY-106254A). This product is intended for research and analytical applications. Vapendavir diphosphate (BTA798 diphosphate) is a potent enteroviral capsid binder (CB). Vapendavir diphosphate (BTA798 diphosphate) possesses potent antiviral activity for enterovirus 71 (EV71) replication, with EC50 values of 0.5-1.4 μM in different EV71 strains.
    Vapendavir diphosphate (Standard)
  • HY-106268AR
    Larazotide acetate (Standard) 881851-50-9 98%
    Larazotide acetate (Standard) is the analytical standard of Larazotide acetate (HY-106268A). This product is intended for research and analytical applications. Larazotide acetate is a peptide which is an orally active zonulin antagonist. Larazotide acetate shows antiviral activity to varicella-zoster virus (VZV) with EC50s of 44.14 and 59.06 μM for strain OKA and 07-1, respectively. Larazotide acetate can be used for the research of celiac disease and infection.
    Larazotide acetate (Standard)
  • HY-106372AR
    Carcainium chloride (Standard) 1042-42-8 98%
    Carcainium chloride (Standard) is the analytical standard of Carcainium chloride (HY-106372A). This product is intended for research and analytical applications. Carcainium chloride (QX 572) is a quaternary derivative of Lidocaine. Antitussive effect.
    Carcainium chloride (Standard)
  • HY-106443AR
    Arimoclomol maleate (Standard) 289893-26-1 98%
    Arimoclomol maleate (Standard) is the analytical standard of Arimoclomol maleate (HY-106443A). This product is intended for research and analytical applications. Arimoclomol maleate (BRX-220) is an orally active co-inducer of heat shock proteins (HSP). Arimoclomol protects motor neurons by enhancing Hsp expression, thus directly affecting protein aggregation and clearance of misfolded assemblies via the proteasome-ubiquitin system.Arimoclomol maleate can be used for the study of Niemann–Pick disease type C.
    Arimoclomol maleate (Standard)
  • HY-106934AR
    Peldesine dihydrochloride (Standard) 2772702-10-8 98%
    Peldesine (dihydrochloride) (Standard) is the analytical standard of Peldesine (dihydrochloride). This product is intended for research and analytical applications. Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine dihydrochloride (Standard)
  • HY-106994AR
    Nebentan potassium (Standard) 342005-82-7 98%
    Nebentan potassium (Standard) (GT-2331 maleate (Standard)) is the analytical standard of Nebentan (potassium) (HY-106994A). This product is intended for research and analytical applications. Nebentan potassium (YM598) is a potent, selective and orally active non-peptide endothelin ETA receptor antagonist through the modification of Bosentan (HY-A0013). Nebentan potassium inhibits [125I] endothelin-1 binding to cloned human endothelin ETA and ETB receptor, with Ki of 0.697 nM and 569 nM, respectively. YM598 can ameliorate the progression of cor pulmonale and myocardial infarction in vivo.
    Nebentan potassium (Standard)
  • HY-107004AR
    Amotosalen hydrochloride (Standard) 161262-45-9 98%
    Amotosalen hydrochloride (Standard) (S-59 (Standard)) is the analytical standard of Amotosalen (hydrochloride) (HY-107004A). This product is intended for research and analytical applications. Amotosalen hydrochloride (S-59) is a light-activated, DNA-, RNA-crosslinKing psoralen compound, which is used to neutralise pathogens. Light-activated Amotosalen binds and permanently crosslinks DNA, preventing replication and thus stopping proliferation of donor T cells. Amotosalen can be used for the study of blood system pathogen reduction technology and graft-versus-host disease (GVHD).
    Amotosalen hydrochloride (Standard)
  • HY-107384AR
    Asimadoline hydrochloride (Standard) 185951-07-9 98%
    Asimadoline hydrochloride (Standard) (EMD-61753 hydrochloride (Standard)) is the analytical standard of Asimadoline (hydrochloride) (HY-107384A). This product is intended for research and analytical applications. Asimadoline (EMD-61753) hydrochloride is an orally active, selective and peripherally active κ-opioid agonist with IC50s of 5.6 nM (guinea pig) and 1.2 nM (human recombinant). Asimadoline hydrochloride has low permeability across the blood brain barrier and has peripheral anti-inflammatory actions. Asimadoline hydrochloride ameliorates allodynia in diabetic rats and has the potential for irritable bowel syndrome (IBS).
    Asimadoline hydrochloride (Standard)
Cat. No. Nombre del producto / Synonyms Application Reactivity