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Cat. No.: HY-103671AR

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IPN60090 dihydrochloride (Standard)

IPN60090 dihydrochloride (Standard) is the analytical standard of IPN60090 dihydrochloride (HY-103671A). This product is intended for research and analytical applications. IPN-60090 dihydrochloride is an orally active and highly selective inhibitor of glutaminase 1 (GLS1; IC₅₀=31 nM), with no activity observed against GLS-2. IPN-60090 dihydrochloride exhibits excellent physicochemical and pharmacokinetic properties in vivo. IPN-60090 dihydrochloride can be used for solid tumors research, such as lung and ovarian cancers.

For research use only. We do not sell to patients.

CAS No.: 2102101-72-2
Formula: C₂₄H₂₉Cl₂F₃N₈O₃
Molecular Weight:605.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IPN60090 dihydrochloride (Standard) Chemical Structure

CAS No.: 2102101-72-2

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Application

The compound is the grade of analytical standard, which is the reference standard supplied assay. It is commonly used in qualitative, quantitative and methodological research experiments in HPLC, GC and MS.

Chemical Information

CAS No. 2102101-72-2
Molecular Weight 605.44
Formula C₂₄H₂₉Cl₂F₃N₈O₃
SMILES

O=C(NC)C1=CN(C[C@H](F)CCC2=NN=C(NC(CC3=NC(C)=CC(OC4CC(F)(F)C4)=C3)=O)C=C2)N=N1.[H]Cl.[H]Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Maria Emilia Di Francesco, et al. Gls1 inhibitors for treating disease. WO2016004404A2.

[2]. Michael J Soth, et al. Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties. J Med Chem. 2020 Nov 12;63(21):12957-12977. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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IPN60090 dihydrochloride (Standard)

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IPN60090 dihydrochloride (Standard)

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IPN60090 dihydrochloride (Standard) Related Classifications

HY-103671AR Related Classifications