1. Metabolic Enzyme/Protease
  2. Glutaminase
  3. UPGL00004

UPGL00004 

Cat. No.: HY-119377
Handling Instructions

UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines.

For research use only. We do not sell to patients.

UPGL00004 Chemical Structure

UPGL00004 Chemical Structure

CAS No. : 1890169-95-5

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Description

UPGL00004 is a potent allosteric glutaminase C (GAC) inhibitor (IC50=29 nM; Kd=27 nM). UPGL00004 strongly inhibits the proliferation of highly aggressive triple-negative breast cancer cell lines[1].

IC50 & Target

IC50: 29 nM (Glutaminase C)[1]
Kd: 27 nM (Glutaminase C)[1]

In Vitro

UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1].

In Vivo

The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model[1].

Molecular Weight

534.66

Formula

C₂₅H₂₆N₈O₂S₂

CAS No.

1890169-95-5

SMILES

O=C(NC1=NN=C(N2CCC(NC3=NN=C(NC(CC4=CC=CC=C4)=O)S3)CC2)S1)CC5=CC=CC=C5

Shipping

Room temperature in continental US; may vary elsewhere

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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UPGL00004
Cat. No.:
HY-119377
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