TG-2-IN-1
Based on 2 publication(s) in Google Scholar
TG-2-IN-1 (Compound D003) is a transglutaminase-2 (TGM-2) inhibitor. TG-2-IN-1 can be used for the research of myopia.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 98.0%
- CAS No.: 135273-74-4
- Formule: C8H13ClN2OS
- Masse moléculaire:220.72
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Stockage:
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) TG-2-IN-1
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Activité biologique
TG-2-IN-1 (0.1-100 μM, 5 days) inhibits the growth of human scleral fibroblasts and the number of cells decreased[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:scleral fibroblast
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Concentration:0.1, 1, 10, 100 μM
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Incubation Time:5 days
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Result:The growth and cell quantity of cells were significantly reduced at 0.1 μM and further decreased in a concentration-dependent manner.
Chemical Information
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CAS No. 135273-74-4
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Appearance Solid
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Masse moléculaire 220.72
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Formule C8H13ClN2OS
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Color Off-white to light brown
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SMILES
CC(CSC1=[N+](C)C=CN1C)=O.[Cl-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
4°C, sealed storage, away from moisture
* The compound is unstable in solutions, freshly prepared is recommended.
Publications (2)
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Journal Impact Factor
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Most Recent
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Aging Cell
Tgm2-Catalyzed Covalent Cross-Linking of IκBα Drives NF-κB Nuclear Translocation to Promote SASP in Senescent Microglia. [Abstract]2025 Jan 3:e14463. PMID: 39749582 -
Int Immunopharmacol
TMEM176A drives anti-apoptotic signaling through TGM2-mediated ERK activation in gastric cancer. [Abstract]2025 Nov 8;168(Pt 1):115798. PMID: 41207103
Solvant et solubilité
H2O : 100 mg/mL (453.06 mM; Need ultrasonic)
DMSO : 25 mg/mL (113.27 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (274 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / H2O | 1 mM | 4.5306 mL | 22.6531 mL | 45.3063 mL | 113.2657 mL |
| 5 mM | 0.9061 mL | 4.5306 mL | 9.0613 mL | 22.6531 mL | |
| 10 mM | 0.4531 mL | 2.2653 mL | 4.5306 mL | 11.3266 mL | |
| 15 mM | 0.3020 mL | 1.5102 mL | 3.0204 mL | 7.5510 mL | |
| 20 mM | 0.2265 mL | 1.1327 mL | 2.2653 mL | 5.6633 mL | |
| 25 mM | 0.1812 mL | 0.9061 mL | 1.8123 mL | 4.5306 mL | |
| 30 mM | 0.1510 mL | 0.7551 mL | 1.5102 mL | 3.7755 mL | |
| 40 mM | 0.1133 mL | 0.5663 mL | 1.1327 mL | 2.8316 mL | |
| 50 mM | 0.0906 mL | 0.4531 mL | 0.9061 mL | 2.2653 mL | |
| 60 mM | 0.0755 mL | 0.3776 mL | 0.7551 mL | 1.8878 mL | |
| 80 mM | 0.0566 mL | 0.2832 mL | 0.5663 mL | 1.4158 mL | |
| 100 mM | 0.0453 mL | 0.2265 mL | 0.4531 mL | 1.1327 mL |
* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.
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