2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-P2636
    Cholecystokinin Precursor (24-32) (rat) 99291-20-0 99.54%
    Cholecystokinin Precursor (24-32) (rat) is a cholecystokinin precursor that can be expressed in the heart, lungs, and kidneys as well as in the gastrointestinal tract and brain. Cholecystokinin is a brain-gut peptide that stimulates gallbladder contraction and pancreatic exocrine secretion and also acts as a neurotransmitter.
    Cholecystokinin Precursor (24-32) (rat)
  • HY-P2677
    CCK (26-31) sulfated 89911-65-9
    CCK (26-31) (sulfated) is the N-terminal fragment of CCK, a peptide hormone found in the gut and brain that stimulates digestion, regulates satiety, and is associated with anxiety.
    CCK (26-31) sulfated
  • HY-P2725
    Glycerol dehydrogenase 9028-14-2
    Glycerol dehydrogenase is a polyol dehydrogenase that catalyzes the NAD-dependent oxidation of glycerol to dihydroxyacetone. Glycerol dehydrogenase can be used for glycerol metabolism in diverse microorganisms.
    Glycerol dehydrogenase
  • HY-P2735
    Phosphorylase b 9012-69-5
    Phosphorylase b is one of the two forms of phosphorylase present in skeletal muscle. The other is Phosphorylase a, which can be transformed into one another. The conversion process requires the addition of divalent metal ions and ATP.
    Phosphorylase b
  • HY-P2736
    Amidase 9012-56-0
    Amidases, a member of nitrilase superfamily, catalyzes the hydrolysis of an amide, leading to the formation of carboxylic acid and ammonia. Amidases contain a conserved stretch of approximately 130 amino acids known as the AS sequence, and play a role in important metabolic processes.
    Amidase
  • HY-P2758
    Diamine oxidase 9001-53-0
    Diamine oxidase (DAO) is an orally active enzyme. Diamine oxidase catalyzes oxidative deamination of various polyamines. Diamine oxidase degrades histamine and polyamines to maintain the metabolic balance of amines in the body. Diamine oxidase is a key regulatory enzyme in rapidly proliferating tissues such as bone marrow and intestinal mucosa. Diamine oxidase can be used in research related to intestinal diseases, small bowel transplant rejection, histamine intolerance, and other conditions.
    Diamine oxidase
  • HY-P2836
    (R)-Mandelonitrile lyase 9024-43-5
    (R)-Mandelonitrile lyase (Mandelonitrile Lyase) is an enzyme that can be isolated from Prunus species.
    (R)-Mandelonitrile lyase
  • HY-P2843
    Citrate lyase 9012-83-3
    Citrate lyase is an enzyme that converts citrate to oxaloacetate.
    Citrate lyase
  • HY-P2944
    Ferredoxin-NADP reductase 9029-33-8
    Ferredoxin-NADP reductase in plants receives electrons from ferredoxin (Fd) at the end of the photosynthetic electron transfer chain and converts NADP+ to NADPH.
    Ferredoxin-NADP reductase
  • HY-P2956
    Fructose 5-dehydrogenase (acceptor) 37250-85-4
    Fructose 5-dehydrogenase (acceptor) (D-Fructose dehydrogenase) is a membrane-bound flavohemo-protein that catalyzes the oxidation of d-fructose to 5-keto-d-fructose. Fructose 5-dehydrogenase (acceptor) consists of three subunits: subunit I (67 kDa), subunit II (51 kDa), and subunit III (20 kDa).
    Fructose 5-dehydrogenase (acceptor)
  • HY-P2957
    Hyaluronate lyase 37259-53-3
    Hyaluronate lyase can cleat hyaluronate (HA) and produce unsaturated disaccharides through a β-elimination reaction. The resulting disaccharides further trigger the downstream pathway and catalyze the next reaction. Hyaluronate lyase helps Streptococcus dysgalactiae subsp.equisimilis (SDSE) acquire nutrients from the host, causing bacterial pathogenicity.
    Hyaluronate lyase
  • HY-P2958
    Choloylglycine hydrolase 37289-07-9
    Choloylglycine hydrolase is a conjugated bile salt hydrolase that catalyses the hydrolysis of amide bond in conjugated bile acids. Choloylglycine hydrolase is expressed by intestinal microbiota. Choloylglycine hydrolase can be studied in research on type 2 diabetes.
    Choloylglycine hydrolase
  • HY-P2964
    Phenylalanine dehydrogenase 69403-12-9
    Phenylalanine dehydrogenase is an NAD+-dependent oxidoreductase targeting L-phenylalanine. Phenylalanine dehydrogenase catalyzes deamination to phenylpyruvate and NADH as part of amino acid metabolism regulation. Phenylalanine dehydrogenase is promising for research of phenylketonuria (PKU).
    Phenylalanine dehydrogenase
  • HY-P3066
    SKF 100398 77453-01-1 ≥98.0%
    SKF 100398 (d(CH2)5Tyr(Et)VAVP), an arginine vasopressin (AVP) analogue, is a specific antagonist of the antidiuretic effect of exogenous and endogenous AVP.
    SKF 100398
  • HY-P3072
    Mastoparan 17 145854-61-1 98.09%
    Mastoparan 17 is a tetradecapeptide. Mastoparan 17 is an inactive analogue of Mastoparan (HY-P0246) .
    Mastoparan 17
  • HY-P3153
    Cathepsin K 94716-09-3
    Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis.
    Cathepsin K
  • HY-P3570
    Adipokinetic hormone II (Locusta migratoria) 98968-94-6 99.58%
    Adipokinetic hormone II (Locusta migratoria) (Lom-AKH-II) is a insect adipokinetic hormone (AKH), enhances fat body cAMP levels in vitro. Insect adipokinetic hormones (AKHs) controls flight-directed mobilization of carbohydrate and lipid from fat body stores, which depends on AKH receptor(s) coupling to cAMP formation and glycogen phosphorylase activation via the stimulatory guanine nucleotide-binding protein (Gs).
    Adipokinetic hormone II (Locusta migratoria)
  • HY-P3584
    (Pro3) GIP, human 299898-52-5 99.79%
    (Pro3) GIP, human ((Pro3) Gastric Inhibitory Peptide, human) is an efficacious, stable and specific human GIP receptor (hGIPR) full agonist. (Pro3) GIP, human has high binding affinity for human GIPR with Ki/ Kd values of 0.90 nM. (Pro3) GIP, human can be used for the research of obesity-related diabetes.
    (Pro3) GIP, human
  • HY-P3704
    Enterostatin (rat) 117137-85-6 98.16%
    Enterostatin (rat), an orally active activation peptide of procolipase, selectively reduces fat intake. Enterostatin (rat) reduces serum cholesterol levels by way of a CCK1 receptor-dependent mechanism.
    Enterostatin (rat)
  • HY-P3899
    [Nle8] Somatostatin (1-28) 84768-30-9 98%
    [Nle8] Somatostatin (1-28) is a derivative of somatosttin (1-28) with norleucine replacing methionine in position 8. [Nle8] Somatostatin (1-28) increases the amylase release.[Nle8] Somatostatin (1-28) increases the cyclic AMP in pancreatic acini .
    [Nle8] Somatostatin (1-28)
Cat. No. Product Name / Synonyms Application Reactivity