Cathepsin K
Based on 1 publication(s) in Google Scholar
Cathepsin K is a cysteine protease with endo and collagenolytic activities. Cathepsin K induces degradation of bone collagen and can be used for the research of osteoporosis.
For research use only. We do not sell to patients.
- CAS No.: 94716-09-3
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) Cathepsin K
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Biological Activity
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cathepsin K |
Cathepsin K potently degrades type I collagen, osteonectin, type II collagen, MMP-9, and TGF-β1, with unique triple helix cleavage activity for type I collagen[1].
Cathepsin K (24-96 h) potently degrades type I collagen, achieving full solubilization of adult cortical bone collagen by 96 h, and generates the NTX epitope with complete efficiency, with optimal activity at pH 6.0[2].
Cathepsin K potently degrades the noncollagenous bone matrix protein osteonectin, but does not degrade fibronectin[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 94716-09-3
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Appearance Liquid
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Color Colorless to light yellow
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SMILES
[Cathepsin K]
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Shipping
Shipping with dry ice.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Sci Adv
Rapid sorting and auxiliary evaluation of malignant breast tumors by accurate imaging analysis of metastasis-related biomarker. [Abstract]2025 Apr 4;11(14):eadr5541. PMID: 40173246
Purity & Documentation
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Data Sheet (267 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
[1]. Dai R, et al. Cathepsin K: The Action in and Beyond Bone. Front Cell Dev Biol. 2020;8:433. Published 2020 Jun 4. [Content Brief]
[2]. Costa AG, et al. Cathepsin K: its skeletal actions and role as a therapeutic target in osteoporosis. Nat Rev Rheumatol. 2011;7(8):447-456. Published 2011 Jun 14. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Cathepsin K Related Classifications
HY-P3153 Related Classifications
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