2. Anti-infection Autophagy
  3. Influenza Virus Autophagy
  4. Rimantadine hydrochloride

Rimantadine (hydrochloride)  (Synonyms: 1-(1-アダマンチル)エチルアミン 塩酸塩)

製品番号: HY-B0338A 純度: 98.0%
COA 取扱説明書 Technical Support

Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity.

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Rimantadine hydrochloride

Rimantadine (hydrochloride) 構造式

CAS 番号 : 1501-84-4

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
100 mg $25 在庫あり
1 g $30 在庫あり
5 g $45 在庫あり
10 g $50 在庫あり
25 g $65 在庫あり
100 g $95 在庫あり
> 100 g   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Other Forms of Rimantadine hydrochloride:

Rimantadine (hydrochloride) 関連抗体

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製品説明

Rimantadine hydrochloride (Flumadine hydrochloride) is an orally active inhibitor for M2 protein, that blocks the hydrogen ion channel activity, prevents the entry and replication of the virus, and exhibits board-spectrum antiviral activity[1].

体外実験

Rimantadine hydrochloride (0-10 μg/mL, 72 h) inhibits the RNA levels of hepatitis A virus (HAV) in Huh7 and IHH cells with IC50 of 6.7 and 1.6 μg/mL[1].
Rimantadine hydrochloride (0-10 μg/mL, 72 h) increases the expression of the autophagy marker LC3, inhibits the phosphorylation of mTOR, increases the number of lysosomes, and promotes autophagy in HAV-infected Huh7 cell[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Rimantadine (hydrochloride) 関連抗体

Cell Autophagy Assay[1]

Cell Line: HAV-infected Huh7 cell
Concentration: 0-10 μg/mL
Incubation Time: 72 h
Result: Induced autophagy.
体内実験

Rimantadine hydrochloride (20-80 mg/kg/day, po for 5 days) exhibits anti-infectious activity with Oseltamivir (HY-13317) in H3N2-infected mouse models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: H3N2-infected mouse models[2]
Dosage: 20-80 mg/kg (combined with 0.8-3.2 mg/kg oseltamivir)
Administration: po for 5 days
Result: Lowered the lung virus titer.
分子量

215.76

分子式

C12H22ClN
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

CC(C1(C[C@H](C2)C3)C[C@H]3C[C@H]2C1)N.Cl
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Store at room temperature, keep dry and cool

*In solvent : -80°C, 6 months; -20°C, 1 month (Store at room temperature, keep dry and cool)
溶剤 & 溶解度
体外: 

DMSO : 50 mg/mL (231.74 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 33.33 mg/mL (154.48 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6348 mL 23.1739 mL 46.3478 mL
5 mM 0.9270 mL 4.6348 mL 9.2696 mL
10 mM 0.4635 mL 2.3174 mL 4.6348 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (11.59 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 33.33 mg/mL (154.48 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.6348 mL 23.1739 mL 46.3478 mL 115.8695 mL
5 mM 0.9270 mL 4.6348 mL 9.2696 mL 23.1739 mL
10 mM 0.4635 mL 2.3174 mL 4.6348 mL 11.5869 mL
15 mM 0.3090 mL 1.5449 mL 3.0899 mL 7.7246 mL
20 mM 0.2317 mL 1.1587 mL 2.3174 mL 5.7935 mL
25 mM 0.1854 mL 0.9270 mL 1.8539 mL 4.6348 mL
30 mM 0.1545 mL 0.7725 mL 1.5449 mL 3.8623 mL
40 mM 0.1159 mL 0.5793 mL 1.1587 mL 2.8967 mL
50 mM 0.0927 mL 0.4635 mL 0.9270 mL 2.3174 mL
60 mM 0.0772 mL 0.3862 mL 0.7725 mL 1.9312 mL
80 mM 0.0579 mL 0.2897 mL 0.5793 mL 1.4484 mL
100 mM 0.0463 mL 0.2317 mL 0.4635 mL 1.1587 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Rimantadine hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Rimantadine1501-84-4Influenza VirusAutophagyorally activeantiviralH3N2Huh7IHHInhibitorinhibitorinhibit

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製品名:
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製品番号:
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