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  4. Sapropterin

Sapropterin  (Synonyms: (6R)-BH4; (6R)-Tetrahydro-L-biopterin)

製品番号: HY-A0124
取扱説明書 Technical Support

Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE).

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Sapropterin dihydrochloride) usually boasts enhanced water solubility and stability.

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Sapropterin

Sapropterin 構造式

CAS 番号 : 62989-33-7

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Sapropterin 関連抗体

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製品説明

Sapropterin ((6R)-BH4; (6R)-Tetrahydro-L-biopterin) is an orally active phenylalanine hydroxylase (PAH) cofactor, which is effective in reducing blood phenylalanine concentrations. Sapropterin can be used in study of phenylketonuria (PKU) phenylketonuria. Sapropterin can aggravate experimental autoimmune encephalomyelitis (EAE)[1][2].

IC50 & Target

Human Endogenous Metabolite

 

体外実験

Sapropterin enhances residual phenylalanine hydroxylase activity to increase phenylalanine oxidation[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Sapropterin 関連抗体
体内実験

Sapropterin (100 mg/kg/day; oral; daily; 22 days) treatment aggravates primary progressive and relapsing-remitting EAE in SJL/J mice, as evidenced by increased clinical EAE scores, elevated plasma long-chain ceramide levels, reduced linolenic acid levels, and increased spinal cord T-cell infiltration[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SJL/J (female, 10-12-week-old, primary progressive and PLP-induced-relapsing-remitting EAE)[2]
Dosage: 100 mg/kg/day
Administration: oral; daily; 22 days
Result: Reached higher maximum clinical EAE scores and showed a significant increase in the area under the curve (AUC) of EAE scores.
Elevated plasma levels of long-chain ceramides (C14Cer, C16Cer, C18Cer, C20Cer, C18GluCer, C24:1GluCer).
Reduced plasma linolenic acid (FA18:3) levels and increased plasma levels of the endocannabinoid 1+2AG.
Showed no significant effect on peripheral T-cell proliferation or subpopulations in the spleen, but increased infiltration of CD4+ and CD8+ T-cells in the spinal cord.
分子量

241.25

分子式

C9H15N5O3
CAS 番号
SMILES

O=C1C2=C(NC(N)=N1)NC[C@](N2)([H])[C@@H](O)[C@@H](O)C
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
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Sapropterin Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sapropterin62989-33-7(6R)-BH4 (6R)-Tetrahydro-L-biopterinEndogenous MetabolitePAHphenylalaninePKUSJL/J miceEAE miceT-cellautoimmune encephalomyelitisInhibitorinhibitorinhibit

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