2. GPCR/G Protein
  3. Protease Activated Receptor (PAR)
  4. TRAP-6

TRAP-6  (Synonyms: PAR-1 agonist peptide; Thrombin Receptor Activator Peptide 6; トロンビンレセプターアクチベーターペプチド6)

製品番号: HY-P0078 純度: 99.98%
COA 取扱説明書 Technical Support

TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4.

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カスタムペプチド

CAS 番号 : 141136-83-6

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 165 在庫あり
Solution
10 mM * 1 mL in Water USD 165 在庫あり
Solid
5 mg $100 在庫あり
10 mg $160 在庫あり
25 mg $352 在庫あり
50 mg $540 在庫あり
100 mg $700 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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カスタマーレビュー

Based on 6 publication(s) in Google Scholar

TRAP-6 関連抗体

Top Publications Citing Use of Products

    TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr 9:141:156736.  [Abstract]

    Trap-6 (25 μM) significantly increased the degree of platelet activation.

    TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2025 Apr 9:141:156736.  [Abstract]

    Immunofluorescence of platelets and neutrophil extracellular traps (NETs) (MPO, CitH3) (scale bar, 40 μm, n = 3). The results showed that significant NETs formation was observed in both the C+Trap-6 (25 μM) group and the C+Trap-6+FMN+CD36 group. #p < 0.05 vs Sham group; ##p < 0.01 vs Sham group; ###p < 0.001 vs Sham group; *p < 0.05 vs MI/R group, **p < 0.01 vs MI/R group, ***p < 0.001 vs MI/R group; $p < 0.05 vs C+Trap-6+FMN group; $$$p < 0.001 vs C+Trap-6+FMN group.

    TRAP-6 purchased from MedChemExpress. Usage Cited in: J Thromb Haemost. 2025 Mar 26:S1538-7836(25)00200-4.  [Abstract]

    To test the effect of LAIR2 on collagen-induced platelet activation, platelets from pregnant women were stimulated with either collagen type I (COL1) or TRAP6, which were either preincubated with or without rhLAIR2 (G). Subsequent aggregometry showed that preincubation with LAIR2 inhibited platelet activation induced by COL1 but not TRAP-6 (50 μM; 30 min)(H).

    TRAP-6 purchased from MedChemExpress. Usage Cited in: Phytomedicine. 2022 Sep:104:154271.

    Influence of DSS on aggregation of platelets induced by TRAP-6 (2 μM). n = 3.

    TRAP-6 purchased from MedChemExpress. Usage Cited in: Mol Med Rep. 2019 Jun;19(6):5291-5300.  [Abstract]

    Detection of expression levels of p‑AKT, AKT, p‑JNK, JNK and NF‑κB using western blotting. Groups: NC, negative control group; CH, a cholesterol stimulation group; CH+T, cholesterol stimulation with TRAP‑6 treatment group; CH+V, cholesterol stimulation with vorapaxar treatment group.

    Protease Activated Receptor (PAR) アイソフォーム固有の製品をすべて表示:

    すべてのアイソフォームを表示
    PAR1 PAR2 PAR4

    • 生物活性

    • 純度とドキュメンテーション

    • 参考文献

    • カスタマーレビュー

    製品説明

    TRAP-6 (PAR-1 agonist peptide), a peptide fragment, is a selective protease activating receptor 1 (PAR1) agonist. TRAP-6 activates human platelets via the thrombin receptor. TRAP-6 shows no activity at PAR4[1].

    IC50 & Target

    PAR1

    96 nM (IC50)

    PAR1

     

    体外実験

    TRAP-6 (0.01-10 μM) triggers calcium mobilization in Xenopus oocytes heterologously expressing PAR1[1].
    TRAP-6 (0.01-10 μM; 30 min) activates human platelets[1].
    TRAP-6 (100 μM) does not cause the platelets of rabbits or rats to change shape, aggregate, release granule contents, or form thromboxane[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    TRAP-6 関連抗体
    体内実験

    TRAP (1 mg/kg; i.v.) produces a biphasic response in blood pressure in inactin-anesthetized rats[3].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
    分子量

    748.87

    分子式

    C34H56N10O9
    CAS 番号
    Appearance

    Solid

    Color

    White to off-white

    Sequence

    Ser-Phe-Leu-Leu-Arg-Asn
    Sequence Shortening

    SFLLRN
    輸送条件

    Room temperature in continental US; may vary elsewhere.
    保管条件
    Sealed storage, away from moisture
    Powder -80°C 2 years
      -20°C 1 year
    In solvent -80°C 6 months
      -20°C 1 month
    溶剤 & 溶解度
    体外: 

    H2O : 25 mg/mL (33.38 mM; Need ultrasonic)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 1.3353 mL 6.6767 mL 13.3535 mL
    5 mM 0.2671 mL 1.3353 mL 2.6707 mL
    10 mM 0.1335 mL 0.6677 mL 1.3353 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

    • Molarity Calculator

    • Dilution Calculator

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始）

    C1

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

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    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
    The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
    純度とドキュメンテーション

    純度: 99.98%

    COA (255 KB) RP-HPLC (233 KB) MS (228 KB)

    取扱説明書 (2659 KB)
    参考文献

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    H2O 1 mM 1.3353 mL 6.6767 mL 13.3535 mL 33.3836 mL
    5 mM 0.2671 mL 1.3353 mL 2.6707 mL 6.6767 mL
    10 mM 0.1335 mL 0.6677 mL 1.3353 mL 3.3384 mL
    15 mM 0.0890 mL 0.4451 mL 0.8902 mL 2.2256 mL
    20 mM 0.0668 mL 0.3338 mL 0.6677 mL 1.6692 mL
    25 mM 0.0534 mL 0.2671 mL 0.5341 mL 1.3353 mL
    30 mM 0.0445 mL 0.2226 mL 0.4451 mL 1.1128 mL

    * Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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    TRAP-6 Related Classifications

    • Molarity Calculator

    • Dilution Calculator

    The molarity calculator equation

    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

    質量   濃度   体積   分子量 *
    = × ×

    The dilution calculator equation

    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    一般には略語で表示されます：C1V1 = C2V2

    濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
    × = ×
    C1   V1   C2   V2
    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    TRAP-6141136-83-6PAR-1 agonist peptide Thrombin Receptor Activator Peptide 6TRAP6TRAP 6Thrombin Receptor Activator Peptide6Thrombin Receptor Activator Peptide 6Thrombin Receptor Activator Peptide-6Protease Activated Receptor (PAR)Thrombin receptorsproteaseactivatingreceptorPAR1plateletsthrombinInhibitorinhibitorinhibit

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    製品名:
    TRAP-6
    製品番号:
    HY-P0078
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