Signaling Pathway

DNA alkylator/crosslinker

DNA alkylator/crosslinker

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DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA alkylator/crosslinker Inhibitors & Modulators (30)

Product Name Catalog No. Brief Description
Altretamine

HY-B0181

Altretamine is an alkylating agent proposed as an antineoplastic.

Altretamine hydrochloride

HY-B0181A

Altretamine is an alkylating agent proposed as an antineoplastic.

Bendamustine D4

HY-13567S

Bendamustine D4 is the deuterium labeled Bendamustine(SDX-105), which is an alkylating agent.

Bendamustine hydrochloride

HY-B0077

Bendamustine Hcl(SDX105; EP-3101) is a DNA-damaging agent with IC50 of 50 μM.

Busulfan

HY-B0245

Busulfan is a bifunctional alkylating agent.

Calicheamicin

HY-19609

Calicheamicin is a potent DNA-binding cytotoxic antibiotic.

Carboplatin

HY-17393

Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism.

Carmustine

HY-13585

Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.

Chlorambucil

HY-13593

Chlorambucil(WR-139013; CB-1348) is a chemotherapy drug that has been mainly used in the treatment of chronic lymphocytic leukemia.

Cyclophosphamide

HY-17420

Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.

Cyclophosphamide hydrate

HY-17420A

Cyclophosphamide is a nitrogen mustard alkylating agent used in the treatment of cancers and autoimmune disorders.

Fotemustine

HY-B0733

Fotemustine (S 10036) is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma.

Ifosfamide

HY-17419

Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.

Lomustine

HY-13669

Lomustine (CCNU) is an alkylating nitrosourea compound used in chemotherapy.

Melphalan

HY-17575

Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA.

Miriplatin

HY-16325A

Miriplatin (SM-11355) is a novel platinum complex used in TACE that shows promise for the treatment of hepatocellular carcinoma (HCC).

Miriplatin hydrate

HY-16325

Miriplatin hydrate was approved for lipiodolization for the treatment of hepatocellular carcinoma in 2009; it is a lipophilic platinum complex containing myristates as leaving groups, and can be easily suspended in ethyl esters of iodized fatty acids obtained from poppy seed oil.

Mitomycin C

HY-13316

Mitomycin C is a DNA crosslinking agent that inhibits DNA synthesis and induces apoptosis in a variety of cells.

Oxaliplatin

HY-17371

Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.

Palifosfamide

HY-14798

Palifosfamide (ZIO-201) is the functional active metabolite of ifosfamide (IFOS), a bi-functional DNA alkylator being investigated as a potential therapy for the treatment of soft tissue sarcoma (STS).