1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker Related Products (30):

Cat. No. Product Name Effect Purity
  • HY-13316
    Mitomycin C
    Mitomycin C is a DNA-damaging agent and small-molecule inhibitor effectively sensitize cancer cells to tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL).
  • HY-17371
    Oxaliplatin
    Oxaliplatin inhibits DNA synthesis by conforming DNA adducts.
  • HY-13753
    Streptozocin
    Streptozocin is a potent DNA-methylating agent, with IC50 values of 11.7, 904 and 1024 μg/mL for HL60, K562 and C1498 cells respectively.
  • HY-17364
    Temozolomide
    Temozolomide is a DNA-methylating agent. Temozolomide is an alkylating cytostatic drug.
  • HY-17420
    Cyclophosphamide
    Cyclophosphamide is a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities.
  • HY-17393
    Carboplatin
    Carboplatin is a chemotherapy drug by binding to DNA and interfering with the cell's repair mechanism.
  • HY-17575
    Melphalan
    Melphalan(Sarcolysin; L-PAM) is a chemotherapy drug belonging to the class of nitrogen mustard alkylating agents; attaches the alkyl group to the guanine base of DNA.
  • HY-14798
    Palifosfamide
    Palifosfamide is a novel DNA alkylator and the active metabolite of ifosfamide, with antitumor activity.
  • HY-13424
    RITA
    RITA(NSC 652287) induced both DNA-protein and DNA-DNA cross-links with no detectable DNA single-strand breaks.
  • HY-14573
    SJG-136
    SJG-136 is a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity.
  • HY-13585
    Carmustine
    Carmustine is a cell-cycle phase nonspecific alkylating antineoplastic agent.
  • HY-B0245
    Busulfan
    Busulfan is a bifunctional alkylating agent.
  • HY-13669
    Lomustine
    Lomustine (CCNU) is an alkylating nitrosourea compound used in chemotherapy.
  • HY-17419
    Ifosfamide
    Ifosfamide is a nitrogen mustard alkylating agent used in the treatment of cancer.
  • HY-17576
    Satraplatin
    Satraplatin(BMS182751; BMY45594; JM216) is a platinum-based antineoplastic agent that is under investigation as one treatment of patients with advanced prostate cancer who have failed previous chemotherapy.
  • HY-B0733
    Fotemustine
    Fotemustine (S 10036) is a nitrosourea alkylating agent approved for use in the treatment of metastasising melanoma.
  • HY-13733
    Procarbazine Hydrochloride
    Procarbazine Hcl, an antineoplastic chemotherapy drug, is an alkylating agent for the treatment of Hodgkin's lymphoma and certain brain cancers; also inhibits MAO thus increasing the effects of sympathomimetics, TCAs, and tyramine.
  • HY-B0077
    Bendamustine hydrochloride
    Bendamustine Hcl(SDX105; EP-3101) is a DNA-damaging agent with IC50 of 50 μM.
  • HY-17574
    Thio-TEPA
    Thio-TEPA(Thioplex; Tiofosfamid) is an alkylating agent used to treat cancer, this molecule features tetrahedral phosphorus and is structurally akin to phosphate.
  • HY-16513
    VAL-083
    VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.