2. Signaling Pathways
  3. Anti-infection
  4. Filovirus

Filovirus

Filovirus

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Filoviruses is amongst the most lethal of primate pathogens. Filoviruses cause lethal hemorrhagic fever in humans and nonhuman primates. The family Filoviridae includes two genera: Marburgvirus, comprising various strains of the Lake Victoria marburgvirus (MARV); and Ebolavirus (EBOVs), comprising four species including Sudan ebolavirus (SEBOV), Zaire ebolavirus (ZEBOV), Ivory Coast ebolavirus (CIEBOV), and Reston ebolavirus (REBOV); and a tentative species Bundibugyo ebolavirus (BEBOV).

The infections typically affect multiple organs in the body and are often accompanied by hemorrhage (bleeding). Once the virus has been transmitted from an animal host to a human, it can then spread through person-to-person contact.

Filovirus Isoform Specific Products:

Filovirus Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-178135
    SCR005
    		Inhibitor
    SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.
    SCR005
  • HY-W143403A
    (-)-Isopinocampheol
    		Inhibitor
    (-)-Isopinocampheol (l-Isopinocampheol) is a compound with anti-filovirus activity. Its derivatives inhibit infection by Ebola virus and Marburg virus, possibly through binding to surface glycoproteins. It also has lysosomal affinity.
    (-)-Isopinocampheol
  • HY-146883A
    As-358 hydrochloride
    		Inhibitor
    As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.
    As-358 hydrochloride
  • HY-160882
    EBOV-IN-7
    EBOV-IN-7 (compound 26) is an inhibitor of the Ebola virus EBOV with an IC50 of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). EBOV-IN-7 has inhibitory effects on cancer cells and inhibits the EBOV-GPcl/NPC1 interaction.
    EBOV-IN-7
  • HY-146815
    CP19
    		Inhibitor
    CP19, a histamine receptor antagonist, is an entry inhibitor against both Ebolavirus (EBOV) and Marburgvirus (MARV) with IC50s of 3.4 μM and 29.5 μM, respectively. CP19 has SI values of 29.4 and 3.4 for EBOV and MARV, respectively. CP19 has antiviral activity.
    CP19
  • HY-160878
    EBOV-IN-3
    		Inhibitor
    EBOV-IN-3 (compound 9) is benzothiazepine compound. EBOV-IN-6 has anti-pEBOV activity with a IC50 value of 0.37 μM.
    EBOV-IN-3
  • HY-161691
    EBOV-IN-9
    		Inhibitor
    EBOV-IN-9 (compound 2b) is Diphyllin derivative that blocks Ebola viral entry with an EC50 of 40 nM. EBOV-IN-9 against EBOV-infected monocyte-derived macrophages with an EC50 of 107 nM.
    EBOV-IN-9
  • HY-149217
    Antiviral agent 27
    Antiviral agent 27 (Compound 12) has notable activity against the Ebola virus (EC50: 14 nM).
    Antiviral agent 27
  • HY-162146
    NS3-IN-1
    		Inhibitor
    NS3-IN-1 (compound 302) is a potent helicase (NS3) inhibitor. NS3-IN-1 shows an potent inhibitor for yellow fever helicase.
    NS3-IN-1
  • HY-139223
    pEBOV-IN-1
    		Inhibitor
    pEBOV-IN-1 (Comp 2) is a pEBOV inhibitor, with an EC50 value of 0.38 μM. pEBOV: pseudotyped Ebola virus.
    pEBOV-IN-1
  • HY-174150
    EBOV entry-IN-2
    		Inhibitor
    EBOV entry-IN-2 (compound 16) is an EBOV entry inhibitor with an EC50 of 4.42 μM. EBOV entry-IN-2 shows metabolic stability.
    EBOV entry-IN-2
  • HY-161956
    Antiviral agent 59
    		Inhibitor
    Antiviral agent 59 (compound 58) is an antiviral agent with selective and drug-like properties that inhibits a broad spectrum of filoviruses. Antiviral agent 59 exhibits low off-target activity and inhibition against replication-competent Ebola virus (EBOV), Sudan virus (SUDV), and Marburg virus (MARV/b>).
    Antiviral agent 59
  • HY-13516R
    Aloperine (Standard)
    		Inhibitor
    Aloperine (Standard) is the analytical standard of Aloperine. This product is intended for research and analytical applications. Aloperine is an alkaloid in sophora plants such as Sophora alopecuroides L, which has shown anti-cancer, anti-inflammatory and anti-virus properties. Aloperine is widely used to treat patients with allergic contact dermatitis eczema and other skin inflammation in China. Aloperine induces apoptosis and autophagy in HL-60 cells.
    Aloperine (Standard)
  • HY-173508
    EBOV entry-IN-1
    		Inhibitor
    EBOV entry-IN-1 (compound Hu7) is an EBOV entry inhibitor with an IC50 of 1.50 μM.
    EBOV entry-IN-1
  • HY-N4118R
    Cephaeline (Standard)
    		Inhibitor
    Cephaeline ((-)-Cephaeline), a desmethyl analog of Emetine, is a phenolic alkaloid in Indian Ipecac roots isolated from the Cephaelis ipecacuanha. Cephaeline exhibits potent inhibition of both Zika virus (ZIKV) and Ebola virus (EBOV) infections. Cephaeline is an inductor of histone H3 acetylation and an inhibitor of mucoepidermoid carcinoma cancer stem cells (MEC), which promotes ferroptosis by inhibiting NRF2 to exert anti-lung cancer efficacy.
    Cephaeline (Standard)
  • HY-125258
    EBOV-IN-11
    		Inhibitor
    EBOV-IN-11 is a protein phosphatase 1 (PP1) inhibitor, with Kd values of 1.88 nM and 8.01 nM against wild-type and quadruple-mutant PP1, respectively. EBOV-IN-11 potently inhibits the replication and transcription of EBOV-eGFP virus. EBOV-IN-11 can be used in studies related to Ebola virus infection.
    EBOV-IN-11
  • HY-170493
    Antiviral agent 66
    		Inhibitor
    Antiviral agent 66 (Compound 60) is the inhibitor for Filovirus, that inhibits pseudotyped virus of Ebola, Marburg, Zaire, Sudan, Bundibugyo, Reston and Tai Forest with EC50s of 0.16, 2.24, 0.16, 0.89, 0.21, 0.21 and 0.11 μM, respectively.
    Antiviral agent 66
  • HY-115848
    Antiviral agent 12
    		Inhibitor
    Antiviral agent 12 is a antiviral compound. Antiviral agent 12 inhibits Ebola virus entry into host cells by binding to surface glycoprotein, EC50 is 3.9 μM. Antiviral agent 12 can be used in the study of Ebola virus.
    Antiviral agent 12
  • HY-B1607R
    Chlorphenoxamine (Standard)
    		Inhibitor
    Chlorphenoxamine (Standard) is the analytical standard of Chlorphenoxamine (HY-B1607). This product is intended for research and analytical applications. Chlorphenoxamine, an antihistamine and anticholinergic agent is a GPCR antagonist. Chlorphenoxamine inhibits multiple lethal viral diseases, such as SARS-CoV, MERS-CoV, EBOV and malaria. Chlorphenoxamine shows anti-filovirus activity against both EBOV and Marburg virus (MARV) with IC50s of 1.1 μM and 6.2 μM, respectively. Chlorphenoxamine is used for allergic conditions, urticaria, viral diseases and Parkinson’s disease.
    Chlorphenoxamine (Standard)
  • HY-150756
    EBOV-GP-IN-1
    		Inhibitor
    EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC50 of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).
    EBOV-GP-IN-1
Filovirus Isoform Comparison

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