EBOV-GP-IN-1
EBOV-GP-IN-1 (Compound 28) is a potent Ebola entry inhibitor with an IC50 of 0.05 μM against Ebola virus envelope glycoprotein (EBOV-GP).
For research use only. We do not sell to patients.
- CAS No.: 3032283-85-2
- Formula: C25H40ClN3O2
- Molecular Weight:450.06
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
- Protocols
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
Description
IC50 & Target
|
EBOV |
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| Huh-7 | CC50 |
5.1 μM
Compound: 28
|
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by cellular ATP method
Cytotoxicity against human Huh-7 cells assessed as reduction in cell viability by cellular ATP method
|
[PMID: 35872393] |
In Vitro
EBOV-GP-IN-1 (Compound 28) (0-80 μM, 2 days) shows cytotoxicity with a CC50 of 5.10 ± 1.56 μM for Huh7 cells in pseudotyped virus assay[1].
EBOV-GP-IN-1 exhibits remarkable selectivity between EBOV-GP and VSV-G (vesicular stomatitis virus glycoprotein) (Spec. Index = 58)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
-
CAS No. 3032283-85-2
-
Molecular Weight 450.06
-
Formula C25H40ClN3O2
-
SMILES
O=C([C@H]1N(C[C@@H](O)CN[C@H](C2=CC=C(Cl)C=C2)C)C[C@@]3([H])CCCC[C@@]3([H])C1)NC(C)(C)C
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
-
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EBOV-GP-IN-1 Related Classifications
HY-150756 Related Classifications
Powered by Bioz