Antiviral agent 12
Based on 1 Customer Validation
Antiviral agent 12 is a antiviral compound. Antiviral agent 12 inhibits Ebola virus entry into host cells by binding to surface glycoprotein, EC50 is 3.9 μM. Antiviral agent 12 can be used in the study of Ebola virus.
For research use only. We do not sell to patients.
- Purity : 98.90%
- CAS No.: 314030-54-1
- Formula: C23H32N2O
- Molecular Weight:352.51
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero | EC50 |
3.9 μM
Compound: 1
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Inhibition of glycoprotein in VSV pseudotyped Ebolavirus infected in African green monkey Vero cells assessed as reduction in virus entry incubated for 24 hrs by luciferase reporter gene assay
Inhibition of glycoprotein in VSV pseudotyped Ebolavirus infected in African green monkey Vero cells assessed as reduction in virus entry incubated for 24 hrs by luciferase reporter gene assay
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[PMID: 32550996] |
Chemical Information
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CAS No. 314030-54-1
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Appearance Solid
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Molecular Weight 352.51
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Formula C23H32N2O
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Color White to off-white
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SMILES
O=C(C12CC3CC(CC(C2)C3)C1)NC4CCN(CC5=CC=CC=C5)CC4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
In Vitro:
DMSO : 20.83 mg/mL (59.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
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Data Sheet (268 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8368 mL | 14.1840 mL | 28.3680 mL | 70.9200 mL |
| 5 mM | 0.5674 mL | 2.8368 mL | 5.6736 mL | 14.1840 mL | |
| 10 mM | 0.2837 mL | 1.4184 mL | 2.8368 mL | 7.0920 mL | |
| 15 mM | 0.1891 mL | 0.9456 mL | 1.8912 mL | 4.7280 mL | |
| 20 mM | 0.1418 mL | 0.7092 mL | 1.4184 mL | 3.5460 mL | |
| 25 mM | 0.1135 mL | 0.5674 mL | 1.1347 mL | 2.8368 mL | |
| 30 mM | 0.0946 mL | 0.4728 mL | 0.9456 mL | 2.3640 mL | |
| 40 mM | 0.0709 mL | 0.3546 mL | 0.7092 mL | 1.7730 mL | |
| 50 mM | 0.0567 mL | 0.2837 mL | 0.5674 mL | 1.4184 mL |
Antiviral agent 12 Related Classifications
HY-115848 Related Classifications
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