2. Anti-infection
  3. SARS-CoV Filovirus Hepatitis E Virus (HEV)
  4. SCR005

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics.

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SCR005

SCR005 Chemical Structure

CAS No. : 2409183-70-4

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SCR005 Related Antibodies

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EBOV MARV ZEBOV

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Description

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics[1].

Cellular Effect
Cell Line Type Value Description References
Vero IC50
1.36 μM
Compound: SCR-7
Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
Antiviral activity against Zika virus harboring subgenomic GFP replicon infected in African green monkey Vero cells assessed as reduction in viral infection preincubated for 30 mins followed by viral infection and measured after 72 hrs
[PMID: 30925051]
In Vitro

SCR005 (10 μM, 30 min) inhibits infection of VERO-TMPRSS2 cells by pseudotyped virus particles (PVPs) from SARS-CoV-1, SARS-CoV-2, MERS-CoV, NiV, HeV, and EBOV[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SCR005 Related Antibodies
In Vivo

SCR005 (3 mg/kg, i.n., single dose) improves survival rate in hACE2 mice infected SARS-CoV-2[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
Dosage: 3 mg/kg
Administration: i.n., single dose
Result: Improved survival rate to 30%.
Decreased lung and brain viral RNA copies by multiple orders of magnitude.
Reduced perivascular infiltrates and necrotic neurons in lung and brain tissues.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with IL-18 and IFN-γ reduced.
Molecular Weight

578.71

Formula

C36H34N8
CAS No.
SMILES

C1(C/N=C/C2=CC=CN2)=CC(C3=CC(C/N=C/C4=CC=CN4)=CC(C/N=C/C5=CC=CN5)=C3)=CC(C/N=C/C6=CC=CN6)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SCR005 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCR0052409183-70-4SCR 005SCR-005SARS-CoVFilovirusHepatitis E Virus (HEV)SARS coronavirusHepatitis E VirushACE2 miceSARS-CoV-2SARS-CoV-1MERS-CoVEBOVMARVNiVHeVInhibitorinhibitorinhibit

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