2. Anti-infection
  3. Filovirus
  4. As-358 hydrochloride

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.

For research use only. We do not sell to patients.

As-358 hydrochloride Chemical Structure

As-358 hydrochloride Chemical Structure

CAS No. : 2374723-26-7

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As-358 hydrochloride Related Antibodies

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Description

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC50s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety[1].

IC50 & Target

IC50: 9.1 μM (Ebola virus), 18.1 μM (Marburg virus)[1]
In Vitro

As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

As-358 hydrochloride Related Antibodies

Cell Proliferation Assay

Cell Line: Vero (infected with EBOV and MARV)[1]
Concentration: 0-500 μM
Incubation Time: 10 days
Result: Exhibits inhibitory activities against EBOV and MARV, with IC50s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.
In Vivo

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: ICR mice[1]
Dosage: 1.08, 0.44, 0.27, and 0.14 g/kg
Administration: IG; single (observed for 7 days)
Result: Exhibited no toxicity to adult mice with intragastric administration, and the LD50 > 1000 mg/kg.
Molecular Weight

329.91

Formula

C18H32ClNO2
CAS No.
SMILES

O=C(O[C@@H]1C[C@@H]2CC[C@]1(C2(C)C)C)CC[NH+]3CCCCC3.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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As-358 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

As-3582374723-26-7As358As 358FilovirusEbola virusMarburg virusLow toxicityICR miceInhibitorinhibitorinhibit

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As-358 hydrochloride
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HY-146883A
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