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Cat. No.: HY-146883A

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As-358 hydrochloride

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC₅₀s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety.

For research use only. We do not sell to patients.

CAS No.: 2374723-26-7
Formula: C₁₈H₃₂ClNO₂
Molecular Weight:329.91

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

As-358 hydrochloride Chemical Structure

CAS No.: 2374723-26-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

As-358 (hydrochloride) has inhibitory effects against Ebola virus and Marburg virus with IC₅₀s of 9.1 μM and 18.1 μM, as well as exhibits good in vivo safety^[1].

IC₅₀ & Target

EBOV

MARV

All Filovirus Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	CC₅₀	87 μM Compound: 3b.HCl	Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293T cells incubated for 48 hrs by MTT assay	[PMID: 32905862]
Vero	CC₅₀	279.1 μM Compound: 3b.HCl	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis Cytotoxicity against African green monkey Vero cells assessed as reduction in cell survival incubated for 10 days by neutral red dye based colorimetric analysis	[PMID: 32905862]

In Vitro

As-358 (hydrochloride) (compound 3b·HCl) (0-500 μM) exhibits inhibitory activities against EBOV and MARV^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay

Cell Line:

Vero (infected with EBOV and MARV)^[1]
Concentration:

0-500 μM
Incubation Time:

10 days
Result:

Exhibits inhibitory activities against EBOV and MARV, with IC₅₀s of 18.1 ± 9.3 μM and 9.1 ± 2.1 μM, SI values of 15 and 31, respectively.

In Vivo

As-358 (hydrochloride) (0.14-1.08 g/kg; IG; single) exhibits no toxicity to adult mice with intragastric administration^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ICR mice^[1]
Dosage:

1.08, 0.44, 0.27, and 0.14 g/kg
Administration:

IG; single (observed for 7 days)
Result:

Exhibited no toxicity to adult mice with intragastric administration, and the LD₅₀ > 1000 mg/kg.

Chemical Information

CAS No. 2374723-26-7
Molecular Weight 329.91
Formula C₁₈H₃₂ClNO₂
SMILES

O=C(O[C@@H]1C[C@@H]2CC[C@]1(C2(C)C)C)CC[NH+]3CCCCC3.[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Sokolova AS, Yarovaya OI, Zybkina AV, et al. Monoterpenoid-based inhibitors of filoviruses targeting the glycoprotein-mediated entry process. Eur J Med Chem. 2020;207:112726. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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