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Cat. No.: HY-160882

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EBOV-IN-7

EBOV-IN-7 (compound 26) is an inhibitor of the Ebola virus EBOV with an IC₅₀ of 2.04 μM against EBOV-GP pseudotyped virus (pEBOV). EBOV-IN-7 has inhibitory effects on cancer cells and inhibits the EBOV-GPcl/NPC1 interaction.

For research use only. We do not sell to patients.

CAS No.: 68207-16-9
Formula: C₁₈H₁₉ClN₄O₃S
Molecular Weight:406.89

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

EBOV-IN-7 Chemical Structure

CAS No.: 68207-16-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target

EBOV

All Filovirus Isoforms :

In Vitro

EBOV-IN-7 (compound 26) has a CC₅₀ of 60 μM on HeLa cells and low cytotoxicity on Vero cells with a CC₅₀ >100 μM^[1].
EBOV-IN-7 (50 μM) significantly interferes with EBOV - GPcl/NPC1 interaction, IC₅₀ against EBOV-GP-pseudotyped virus (pEBOV) is 2.04 μM^[1].
EBOV-IN-7 IC₅₀ against African swine fever virus ASFV is 15.75 μM[1].br /

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 68207-16-9
Molecular Weight 406.89
Formula C₁₈H₁₉ClN₄O₃S
SMILES

O=C(NNC1=CC=CC=C1SC2=CC(Cl)=CC=C2[N+]([O-])=O)CN3CCCC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Lasala F, et al. Identification of potential inhibitors of protein-protein interaction useful to fight against Ebola and other highly pathogenic viruses. Antiviral Res. 2021 Feb;186:105011. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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