2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-173490
    Antifungal agent 131
    		Inhibitor
    Antifungal agent 131 (compound A20) is an antifungal compound with a minimum inhibitory concentration (MIC) of 64 μg/mL. Antifungal agent 131 demonstrates excellent antifungal potential when used in combination with Fluconazole (HY-B0101).
    Antifungal agent 131
  • HY-N15012
    6-O-Demethyl-5-deoxyfusarubin
    		Inhibitor
    6-O-Demethyl-5-deoxyfusarubin has the ability of anti-fungal and mycoplasma.
    6-O-Demethyl-5-deoxyfusarubin
  • HY-179138
    CYP51-IN-28
    		Inhibitor
    CYP51-IN-28 (compound B9) is a CYP51 inhibitor. CYP51-IN-28 is an efficient, broad-spectrum, and low toxicity antifungal molecule. CYP51-IN-28 can be used for research on fungal infections.
    CYP51-IN-28
  • HY-N14111
    Cuevaene A
    		Inhibitor
    Cuevaene A can be isolated from the strain of gdmAI-disrupted Streptomyces sp. LZ35 and. Cuevaene A displays moderate activity against Gram-positive bacteria (e.g., Bacillus subtilis strain ATCC 11060) and modest activity against fungi (e.g., Fusarium verticillioides strain S68 and Rhizoctonia solani strain GXE4).
    Cuevaene A
  • HY-N12679
    Phoslactomycin D
    		Inhibitor
    Phoslactomycin D has weak effect against Gram-positive bacteria, but has strong effect against fungi.
    Phoslactomycin D
  • HY-136759
    CYP51-IN-9
    		Inhibitor
    CYP51-IN-2 (compound 1i), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 62.5 for Microsporum gypseum and Candida albicans.
    CYP51-IN-9
  • HY-183705
    Antimicrobial agent-50
    		Inhibitor
    Antimicrobial agent-50 is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC50 of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC50 values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively.
    Antimicrobial agent-50
  • HY-170816
    CYP51/Hsp90-IN-1
    		Inhibitor
    CYP51/Hsp90-IN-1 (Compound MM4) is a dual CYP51/Hsp90 inhibitor. CYP51/Hsp90-IN-1 shows antifungal activity against Candida albicans and effectively inhibits important fungal virulence factors. CYP51/Hsp90-IN-1 is promising for research of invasive candidiasis.
    CYP51/Hsp90-IN-1
  • HY-136762
    CYP51-IN-12
    		Inhibitor
    CYP51-IN-2 (compound 1l), a Fluconazole (HY-B0101) analog, is a potent antifungal agent. CYP51-IN-2 shows MIC80 of 15.6 ng/mL for Microsporum gypseum and Candida albicans.
    CYP51-IN-12
  • HY-17373A
    Posaconazole hydrate
    		Inhibitor
    Posaconazole hydrate is a broad-spectrum, second generation, triazole compound with antifungal activity.
    Posaconazole hydrate
  • HY-P5588
    Dermaseptin-S4
    		Inhibitor
    Dermaseptin-S4 is an antimicrobial peptide derived from frog skin against filamentous fungi.
    Dermaseptin-S4
  • HY-178801
    SDH-IN-39
    		Inhibitor
    SDH-IN-39 (Compound A16) is a SDH inhibitor, with an IC50 value of 6.83 μg/mL. SDH-IN-39 is also an antifungal agent. SDH-IN-39 shows antifungal activity against Rhizoctonia solani (EC50 of 1.49 μg/mL), G. zeae, C. gloeosporioides, S. sclerotiorum and M. oryzae.
    SDH-IN-39
  • HY-N8519
    Urdamycin B
    		Inhibitor
    Urdamycin B is an antibiotic that effectively inhibits fungi and bacteria. Urdamycin B also exhibits anti-proliferative activity against mouse leukemia cells L1210. Urdamycin B can be obtained from the metabolic products of Streptomyces fradiae. Urdamycin B can be used for research on cancer as well as bacterial and fungal infections.
    Urdamycin B
  • HY-W028039
    4,4-Dimethyloxazolidine
    		Inhibitor
    4,4-Dimethyloxazolidine is an antimicrobial agent used in industrial processing chemicals and specialty industrial products to inhibit the growth of bacterial and fungal.
    4,4-Dimethyloxazolidine
  • HY-N12475
    Solavetivone
    		Inhibitor
    Solavetivone is a Sesquiterpenoid phytoalexin and Antifungal agent. Solavetivone is isolated from stress-challenged potato plants. Solavetivone is hydroxylated by sesquiterpenoid phytoalexin hydroxylase (SPH/CYP76A2L). Solavetivone helps solanaceous plants defend against pathogens, damages plant cells after pathogen threat, and inhibits mycelial growth of Rhizoctonia solani. Solavetivone is applicable to studies related to Rhizoctonia solani infection.
    Solavetivone
  • HY-N14444
    Haliangicin D
    		Inhibitor
    Haliangicin D has anti-filamentous fungi activity, and it also has effect on oomycetes, but has no antibacterial activity.
    Haliangicin D
  • HY-N6245
    Daphylloside
    		Inhibitor 99.35%
    Daphylloside is an iridoid isolated from the aerial parts of Galium verum. Daphylloside has antifungal activity.
    Daphylloside
  • HY-170616
    JH-FK-08
    		Inhibitor
    JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models.
    JH-FK-08
  • HY-W103183R
    Ferron (Standard)
    		Inhibitor
    Ferron (Standard) is the analytical standard of Ferron. This product is intended for research and analytical applications. Ferron (8-Hydroxy-7-iodo-5-quinolinesulfonic acid) has antiseptic and antifungal activity. Ferron can prevent skin and mucosa bacterial irritations and inflammations.
    Ferron (Standard)
  • HY-121443
    Cyflufenamid
    		Inhibitor
    Cyflufenamid is an oxime amide fungicide. Cyflufenamid inhibits the formation of haustoria, colonies and spores of Blumeria graminis f. sp. tritici, and prevents germ tube elongation of Monilinia fructicola. Cyflufenamid is applicable to research related to powdery mildew and brown rot.
    Cyflufenamid
Cat. No. Product Name / Synonyms Application Reactivity