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Cat. No.: HY-170616

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JH-FK-08

JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC₅₀ of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models.

For research use only. We do not sell to patients.

CAS No.: 3062848-75-0
Formula: C₄₅H₇₃N₃O₁₃
Molecular Weight:864.07

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

JH-FK-08 Chemical Structure

CAS No.: 3062848-75-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

All Interleukin Related Isoforms :

Chemical Information

CAS No. 3062848-75-0
Molecular Weight 864.07
Formula C₄₅H₇₃N₃O₁₃
SMILES

O=C(C([C@]1(O)O[C@H]2[C@@H](OC)C[C@H]1C)=O)N3CCCC[C@H]3C(O[C@@H]([C@H](C)[C@H](C/C([C@H](CC)/C=C(C[C@H](C)C[C@@H]2OC)\C)=N/NC(OC)=O)O)/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Molecular Biology Cell Biology

RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Dome PA, et al., Structure-guided design and synthesis of C22- and C32-modified FK520 analogs with enhanced activity against human pathogenic fungi. bioRxiv [Preprint]. 2024 Nov 8:2024.09.27.615491. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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