3062848-75-0
Chemical Structure
JH-FK-08
- CAS 番号: 3062848-75-0
- Formula:C45H73N3O13
- Molecular Weight:864.07
InChIKey: KZHXJIMMUSFOEN-WZFPVHIYSA-N
SMILES: O=C(C([C@]1(O)O[C@H]2[C@@H](OC)C[C@H]1C)=O)N3CCCC[C@H]3C(O[C@@H]([C@H](C)[C@H](C/C([C@H](CC)/C=C(C[C@H](C)C[C@@H]2OC)\C)=N/NC(OC)=O)O)/C(C)=C/[C@H]4C[C@@H](OC)[C@H](O)CC4)=O
Biological Activity: JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models[1].
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JH-FK-08 | JH-FK-08 is an inhibitor for the serine/threonine-specific phosphatase calcineurin. JH-FK-08 exhibits antifungal activity that inhibits C. neoformans with MIC80 of 0.8 µg/mL. JH-FK-08 exhibits immunosuppressive activity and inhibits the IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 exhibits anti-infectious activity in mouse models. | |||||||||||||||||||||
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