Antimicrobial agent-50 

Antimicrobial agent-50 (Compound C2) is an anti-oomycete and Fungicidal agent. Antimicrobial agent-50 inhibits the activity of Mitochondrial respiratory chain complex III with an IC₅₀ of 6.05 mg/L. Antimicrobial agent-50 inhibits ATP synthesis. Antimicrobial agent-50 exhibits protective activity against Phytophthora capsici in vivo. Antimicrobial agent-50 potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC₅₀ values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively^[1].

Antimicrobial agent-50 (0.39-50.00 mg/L) potently inhibits mycelial growth of Gaeumannomyces graminis, Rhizoctonia solani and Phytophthora capsici, with EC₅₀ values of 2.97 mg/L, 1.86 mg/L and 0.74 mg/L, respectively. At a concentration of 50.00 mg/L, this compound exhibits broad-spectrum in vitro fungicidal activity against another 6 tested phytopathogenic fungi/oomycetes^[1].
Antimicrobial agent-50 causes severe ultrastructural damage to Phytophthora capsici hyphae, including cell wall thickening, mitochondrial degradation, and vacuole enlargement^[1].
Antimicrobial agent-50 (12.50-50.00 mg/L) significantly inhibits the respiratory metabolism of Phytophthora capsici hyphae in a concentration-dependent manner, with an inhibition rate of 75.3% at 50.00 mg/L after 4 h of treatment^[1].
Antimicrobial agent-50 (1-100 mg/L) inhibits the activity of mitochondrial respiratory chain complex III in Phytophthora capsici, with an IC₅₀ of 6.05 mg/L, thereby causing a concentration-dependent decrease in intracellular ATP levels^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Antimicrobial agent-50 (500-50000 mg/L; administered locally to the thorax; single dose) shows low toxicity to adult worker bees, with an LD₅₀ greater than 200 μg/bee^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

266.29

C₁₇H₁₄O₃

177776-73-7

O=C1OC(C2=CC=CC(OC3=CC=CC=C3)=C2)CC1=C

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yang D, et al. Design, Synthesis, and Antifungal Evaluation of Novel α-Methylene-γ-Butyrolactone Derivatives Bearing a Diaryl Ether Moiety for Phytopathogen Control. J Agric Food Chem. 2026;74(18):14348-14361.