Solavetivone
Solavetivone is a Sesquiterpenoid phytoalexin and Antifungal agent. Solavetivone is isolated from stress-challenged potato plants. Solavetivone is hydroxylated by sesquiterpenoid phytoalexin hydroxylase (SPH/CYP76A2L). Solavetivone helps solanaceous plants defend against pathogens, damages plant cells after pathogen threat, and inhibits mycelial growth of Rhizoctonia solani. Solavetivone is applicable to studies related to Rhizoctonia solani infection.
For research use only. We do not sell to patients.
- CAS No.: 54878-25-0
- Formula: C15H22O
- Molecular Weight:218.33
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
CYP76A2L |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
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| OVCAR-3 | IC50 |
0.1 mM
Compound: 1, Solavetivone
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Cytotoxicity against human OVCAR-3 cells
Cytotoxicity against human OVCAR-3 cells
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[PMID: 11575964] |
In Vitro
Solavetivone (3.2-16.1 μg/mL; 48 h) inhibits in vitro mycelial growth of Rhizoctonia solani in a concentration-dependent manner, with 27.6% inhibition observed at 16.1 μg/mL after 48 h incubation[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 54878-25-0
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Molecular Weight 218.33
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Formula C15H22O
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SMILES
C[C@H]1[C@@]2(C(C)=CC(C1)=O)C[C@@H](CC2)C(C)=C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
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Filamentous Fungal Mold Culture and Sporulation
Filamentous fungal mold culture and sporulation assays grow hyphae under defined nutritional and environmental conditions until asexual spores, commonly conidia, are produced; the main readouts are colony growth, sporulation onset, conidial yield, conidial morphology, viability, and, when relevant, downstream infectivity or stress phenotype.
Purity & Documentation
References
[1]. Camagna M, et al. Detoxification of the solanaceous phytoalexins rishitin, lubimin, oxylubimin and solavetivone via a cytochrome P450 oxygenase. Plant Signal Behav. 2020;15(2):1707348. [Content Brief]
[3]. Yao MK, et al. Effect of mycorrhization on the accumulation of rishitin and solavetivone in potato plantlets challenged with Rhizoctonia solani. Mycorrhiza. 2003;13(6):333-336. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Solavetivone Related Classifications
HY-N12475 Related Classifications
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Keywords
- Solavetivone
- 54878-25-0
- Fungal
- Cytochrome P450
- sesquiterpenoid phytoalexins hydroxylase
- Glomus etunicatum
- Hyoscyamus muticus
- calcium-alginate immobilized Hyoscyamus muticus cells
- Solanum plants
- Rhizoctonia solani
- Nicotiana benthamiana
- SPH/CYP76A2L
- Solanum tuberosum cv. Goldrush
- potato roots
- Inhibitor
- inhibitor
- inhibit