2. シグナル伝達
  3. Anti-infection
  4. Fungal

Fungal

Fungal

Related Products

PDF 2.4 MB

An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

製品番号 製品名 製品効果 純度 構造式
  • HY-P2890C
    Laccase, Rhus vernicifera
    Laccase, Trametes versicolor (EC 1.10.3.2), is a blue copper oxidase that reduces molecular oxygen to water. Laccase can oxidize polyphenols, methoxylated phenolic compounds, and diamines, but not tyrosine. Laccase's oxidation reaction is a single-electron reaction and produces free radicals.
    Laccase, Rhus vernicifera
  • HY-N1049
    Zeorin Inhibitor
    Zeorin is a compound isolated from the lichen Parmotrema sancti-angelii.
    Zeorin
  • HY-N18360
    Tunicamycin X Inhibitor
    Tunicamycin X (Tunicamycin 17:1) is a nucleoside Antibiotic. Tunicamycin X is isolated from Streptomyces xinghaiensis SCSIO S15077. Tunicamycin X acts as a growth inhibitor against bacteria and fungi. Tunicamycin X inhibits the growth of Bacillus thuringiensis strains. Tunicamycin X inhibits the growth of Candida albicans strains.
    Tunicamycin X
  • HY-158321
    SDH-IN-15 Inhibitor
    SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC50=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.
    SDH-IN-15
  • HY-145873
    BI-10
    BI-10 is an antifungal compound. BI-10 combined with Fluconazole can inhibit hyphal growth, result in ROS accumulation, and decrease mitochondrial membrane potential (MMP) as well as altering membrane permeability.
    BI-10
  • HY-N2573
    Corydalmine Inhibitor 99.74%
    Corydalmine (L-Corydalmine) inhibits spore germination of some plant pathogenic as well as saprophytic fungi. Corydalmine acts as an oral analgesic agent, exhibiting potent analgesic activity. Corydalmine alleviates Vincristine-induced neuropathic pain in mice by inhibiting an NF-κB-dependent CXCL1/CXCR2 signaling pathway.
    Corydalmine
  • HY-N19824
    Koninginin D Inhibitor
    Koninginin D is a potent antifungal agent that can be isolated from fungi including Trichoderma applanatum. Koninginin D inhibits growth of various fungal species including Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana and so on. Koninginin D can be used for the research of fungal infection.
    Koninginin D
  • HY-109706
    (Rac)-CPI-098 Inhibitor
    (Rac)-CPI-098 shows antibacterial activity. (Rac)-CPI-098 exhibits superior anti-fungal activity against Monascus ruber, better activity against Aspergillus fumigates, good activity against Aspergillus niger and Aspergillus parasites and moderate activity against Candida albicans.
    (Rac)-CPI-098
  • HY-155004
    SDH-IN-3 Inhibitor
    SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC50 of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research.
    SDH-IN-3
  • HY-126559
    Ansatrienin A Inhibitor
    Ansatrienin A is an antifungal antibiotic that can be isolated from Streptomyces collinus.
    Ansatrienin A
  • HY-N16432
    Nidulol
    Nidulol is a compound that can be isolated from the fungus Aspergillus nidulans metabolites. Nidulol shows no phytotoxic activity against Zea mays and Medicago polymorpha L. at a concentration of 5 mM.
    Nidulol
  • HY-N12230
    Penicolinate B Inhibitor
    Penicolinate B is a picolinic acid derivative that can be isolated from Penicillium sp. Penicolinate B exhibits antimalarial activity (IC50: 1.40 μg/mL), antitubercular activity (MIC: 25.0 μg/mL), activity against Bacillus cereus (IC50: 25.0 μg/mL), and activity against Candida albicans (IC50: 1.45 μg/mL). Penicolinate B also has certain cytotoxicity against cancer cells such as MCF-7, KB, and NCI-H187. Penicolinate B can be used in research on malaria, tuberculosis, bacterial/fungal infections and tumors.
    Penicolinate B
  • HY-N6687B
    Calcimycin hemimagnesium Inhibitor
    Calcimycin (A-23187) hemimagnesium is an antibiotic and a unique divalent cation ionophore (like calcium and magnesium). Calcimycin hemimagnesium induces Ca2+-dependent cell death by increasing intracellular calcium concentration. Calcimycin hemimagnesium inhibits the growth of Gram-positive bacteria and some fungi. Calcimycin hemimagnesium also inhibits the activity of ATPase and uncouples oxidative phosphorylation (OXPHOS) of mammalian cells. Calcimycin hemimagnesium induces apoptosis and autophagy.
    Calcimycin hemimagnesium
  • HY-W540874
    1-Heptadecene Inhibitor
    1-Heptadecene is a metabolite found in Aporosa cardiosperma. 1-Heptadecene has antifungal and antibacterial activities.
    1-Heptadecene
  • HY-147805
    SARS-CoV-2 3CLpro-IN-4 Inhibitor
    SARS-CoV-2 3CLpro-IN-4 (Compound 5g) is a SARS CoV-2 3CLpro inhibitor with antiviral, antibacterial and antifungal activities.
    SARS-CoV-2 3CLpro-IN-4
  • HY-183333
    CHNQD-02204 Inhibitor
    CHNQD-02204 is a potent and selective antifungal agent with in vitro activity against Candida albicans, with a MIC of 0.025 μg/mL. CHNQD-02204 inhibits ergosterol biosynthesis, disrupts the membrane integrity and biofilm formation of Candida albicans, and suppresses the morphological transition of Candida albicans from yeast to hyphal form. CHNQD-02204 can be used in studies related to candidal infections.
    CHNQD-02204
  • HY-N10289
    Cytosporone C
    Cytosporone C is an antifungal metabolite from the Melia azedarach-Associated Fungus Diaporthe eucalyptorum. Cytosporone C exhibits antifungal activities against Alternaria solani.
    Cytosporone C
  • HY-151566
    Antifungal agent 46 Inhibitor
    Antifungal agent 46 (compound 2f) is a potent antifungal agent. Antifungal agent 46 prevents Ras signaling by inhibiting protein farnesyltransferase.
    Antifungal agent 46
  • HY-148294
    Monogalactosyl diglyceride Inhibitor
    Monogalactosyl diglyceride is a antimicrobial. Monogalactosyl diglyceride has antibacterial activity and antifungal activity in vitro.
    Monogalactosyl diglyceride
  • HY-162296
    Antibacterial agent 188 Inhibitor
    Antibacterial agent 188 (compound 2d) is an antibacterial agent that inhibits dermatophyte activity.
    Antibacterial agent 188
製品番号 製品名 / Synonyms Application Reactivity