SDH-IN-3 

SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC₅₀ of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC₅₀ of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research^[1].

IC50: 7.2 mg/L succinate dehydrogenase (SDH)^[1]

SDH-IN-3(Compound T6) (40 μg/mL; 6-7 days) has in vivo protective and curative activities against rice infected with N.oryzae mycelia 81.5% and 43.0%, respectively^[1].
SDH-IN-3 (0-40 μg/mL; 14-80 hours) significantly inhibits the growth of N.oryzae mycelia and hinders spore germination and germ tube elongation^[1].
SDH-IN-3(0-20 μg/mL; 12-36 hours) affects the mycelium membrane integrity of N.oryzae mycelia by increasing cell membrane permeability and causing peroxidation of cellular lipids^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

319.33

C₁₅H₁₁F₂N₃OS

2805297-11-2

O=C(NC1=CSC=C1)C2=C(C(F)F)N(C3=CC=CC=C3)N=C2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Zhang C, et.al. Design, Synthesis, and Study of the Dual Action Mode of Novel N-Thienyl-1,5-disubstituted-4-pyrazole Carboxamides against Nigrospora oryzae. J Agric Food Chem. 2023 May 17;71(19):7210-7220.  [Content Brief]