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United States

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Cat. No.: HY-158321

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SDH-IN-15

SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.

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Formule: C₂₁H₁₉BrF₂N₄O₂
Masse moléculaire:477.30

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

SDH-IN-15 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Protocole (1)
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

SDH-IN-15 shows antifungal activity of EC₅₀=0.039 μg/mL (R. solani); 0.426 μg/mL (S. sclerotiorum); and 3.482 μg/mL (B. cinerea), respectively. Superior to Boscalid (HY-119976) and Fluxapyroxad (HY-135549)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

In Vivo

SDH-IN-15 (100 μg/mL; 5 days) shows a significant inhibitory effect on the growth of R. solani on rice leaves with a protection efficiency of 86.8%, which is significantly better than the control drugs Boscalid (HY-119976) (68.1%) and Fluxapyroxad (HY-135549) (80.6%)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 477.30
Formule C₂₁H₁₉BrF₂N₄O₂
SMILES

O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2/C(C)=N/OCC3=CC=C(Br)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocole

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Luo B, et al. Novel Pyrazole-4-Carboxamide Derivatives Containing Oxime Ether Group as Potential SDHIs to Control Rhizoctonia solani. J Agric Food Chem. 2024 May 1;72(17):9599-9610. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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