SDH-IN-15

Cat. No.: HY-158321: FAQs
Data Sheet Handling Instructions

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SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death.

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SDH-IN-15 Chemical Structure

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Description	SDH-IN-15 (Compound 5e) is an inhibitor of succinate dehydrogenase (SDH) (IC₅₀=2.04 μM). SDH-IN-15 has significant antifungal activity. SDH-IN-15 blocks the mitochondrial respiratory chain of the fungus through inhibition of SDH, resulting in fungal death^[1].
In Vitro	SDH-IN-15 shows antifungal activity of EC₅₀=0.039 μg/mL (R. solani); 0.426 μg/mL (S. sclerotiorum); and 3.482 μg/mL (B. cinerea), respectively. Superior to Boscalid (HY-119976) and Fluxapyroxad (HY-135549)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. SDH-IN-15 Related Antibodies
In Vivo	SDH-IN-15 (100 μg/mL; 5 days) shows a significant inhibitory effect on the growth of R. solani on rice leaves with a protection efficiency of 86.8%, which is significantly better than the control drugs Boscalid (HY-119976) (68.1%) and Fluxapyroxad (HY-135549) (80.6%)^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight	477.30
Formula	C₂₁H₁₉BrF₂N₄O₂
Unlabeled CAS
SMILES	O=C(C1=CN(C)N=C1C(F)F)NC2=CC=CC=C2/C(C)=N/OCC3=CC=C(Br)C=C3
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (270 KB) Handling Instructions (2659 KB)
References	[1]. Luo B, et al. Novel Pyrazole-4-Carboxamide Derivatives Containing Oxime Ether Group as Potential SDHIs to Control Rhizoctonia solani. J Agric Food Chem. 2024 May 1;72(17):9599-9610. [Content Brief]

SDH-IN-15 Related Classifications

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SDH-IN-15FungalSuccinate DehydrogenaseSDHIspyrazole-4-carboxamidesoxime etheroxime esterantifungal activitiesantifungal mechanismInhibitorinhibitorinhibit

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SDH-IN-15

SDH-IN-15 Related Antibodies

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