Koninginin D
Koninginin D is a potent antifungal agent that can be isolated from fungi including Trichoderma applanatum. Koninginin D inhibits growth of various fungal species including Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana and so on. Koninginin D can be used for the research of fungal infection.
For research use only. We do not sell to patients.
- CAS No.: 119903-56-9
- Formula: C16H26O5
- Molecular Weight:298.37
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Koninginin D inhibits the growth of Listeria monocytogenes, Bacillus subtilis, Pseudomonas aeruginosa, Escherichia coli, Edwardsiella megii, and Vibrio alginolyticus with minimum inhibitory concentrations of 256 μg/mL, 128 μg/mL, and 64 μg/mL, respectively[3].
Koninginin D inhibits the growth of Gaeumannomyces graminis var. tritici, Bipolaris sorokiniana, Pythium middletonii, Fusarium oxysporum, Phytophthora cinnamomi, Rhizoctonia solani at 10 μg/disk and Ceratobasidium cornigerum with an MIC of 64 μg/mL[3].
Koninginin D (50 μM) exhibits significant cytotoxic activity against A549, HeLa, and HepG2 cancer cell lines[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
Chemical Information
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CAS No. 119903-56-9
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Molecular Weight 298.37
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Formula C16H26O5
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SMILES
O[C@H]1C2=C([C@@H](CCC2=O)O)O[C@](C1)([H])[C@@H](O)CCCCCC
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Structure Classification
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Initial Source
Trichoderma koningii
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Research Protocol for Infectious Diseases
Infectious-disease experiments test how pathogens interact with host barriers, innate immune receptors, inflammatory signaling, pathogen replication, and tissue injury; pattern-recognition receptors such as TLRs, RIG-I-like receptors, NOD-like receptors, and inflammasomes detect microbial molecules and activate NF-κB, interferon, and cytokine responses. The central hypothesis is that infection severity reflects the balance between pathogen burden and host response: protective inflammation restricts pathogen growth, whereas excessive or mislocalized inflammation contributes to tissue damage and disease phenotype. Unresolved questions include which host pathways are protective versus pathogenic, why some infection models fail to translate to human disease, and which combined readouts best predict clinically relevant infection outcomes.
Purity & Documentation
References
[1]. Chen L, et al. Trichodermatides E and F from fungus Trichoderma applanatum. J Asian Nat Prod Res. 2019 Jul;21(7):659-665. [Content Brief]
[2]. Song F, et al. Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. J Nat Prod. 2010;73(5):806-810. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Koninginin D Related Classifications
HY-N19824 Related Classifications
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