Trichodermatides E and F from fungus Trichoderma applanatum

  • J Asian Nat Prod Res. 2019 Jul;21(7):659-665. doi: 10.1080/10286020.2018.1465051.
Lin Chen  1  2  3 ,  Guang-Wei Wu  1 ,  Dong Liu  4 ,  Wen-Ying Zhuang  1 ,  Wen-Bing Yin  1  3
Affiliations
  • 1. a State Key Laboratory of Mycology, Institute of Microbiology , Chinese Academy of Sciences , Beijing 100101 , China.
  • 2. b Zhengzhou Key Laboratory of Medicinal Resources Research, Institute of Nanostructured Functional Materials , Huanghe Science and Technology College , Zhengzhou 450006 , China.
  • 3. c Savaid Medical School , University of Chinese Academy of Sciences , Beijing 100049 , China.
  • 4. d State Key Laboratory of Natural and Biomimetic Drugs , Peking University , Beijing 100191 , China.
PMID: 29685076 DOI: 10.1080/10286020.2018.1465051
Abstract

Two new polyketide derivatives, trichodermatides E (1) and F (2), are unprecedented examples of a polyketide with 6/6/6/6 tetracyclic skeleton, together with five known analogs koninginin B (3), koninginin D (4), 7-O-methylkoninginin D (5), koninginins E and F (6-7), were isolated from the plant endophytic fungus Trichoderma applanatum. The structures of these two compounds were determined by NMR data and HR-ESI-MS analysis. The putative biosynthesis of compounds 1-7 was presented.

Keywords
antifungal; polyketides; trichodermatides.
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