2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W005297
    4,6-Dimethoxysalicylaldehyde
    		Inhibitor 99.96%
    4,6-dimethoxysalicylaldehyde is an antifungal agent. 4,6-dimethoxysalicylaldehyde has considerable activity against C. albicans and slight activity against S. cerevisiae.
    4,6-Dimethoxysalicylaldehyde
  • HY-B2064R
    Carboxin (Standard)
    		Inhibitor
    Carboxin (Standard) is the analytical standard of Carboxin. This product is intended for research and analytical applications. Carboxin (Carboxine) is a systemic agricultural fungicide and seed protectant.
    Carboxin (Standard)
  • HY-113542
    Blasticidin A
    		Inhibitor
    Blasticidin A ((+)-Blasticidin A) is a tetraamide acid derivative antibiotic produced by Streptomyces griseochromogenes, as well as a selective inhibitor of aflatoxin production. Blasticidin A exhibits antimicrobial activity against yeast. Blasticidin A can be used in research related to aflatoxin contamination (infection by Aspergillus sp.).
    Blasticidin A
  • HY-128429R
    Trans-​2-​Hexenal (Standard)
    		Inhibitor
    Trans-​2-​Hexenal (Standard) is the analytical standard of Trans-​2-​Hexenal. This product is intended for research and analytical applications. Trans-​2-​Hexenal can be used for the determination of low-molecular-weight carbonyl compounds which are reactive with biological nucleophiles in biological samples.
    Trans-​2-​Hexenal (Standard)
  • HY-119898
    Alloocimene
    		Inhibitor
    Alloocimene is a diterpenoid that activates defense genes and induces resistance to Botrytis cinerea in Arabidopsis thaliana.
    Alloocimene
  • HY-148992
    APX879
    		Inhibitor
    APX879 is a fungal-specific calcineurin inhibitor that has less immunosuppressive activities and toxicities. APX879 is a C22-modified FK506 (HY-13756) analog, which maintains broad-spectrum antifungal activity.
    APX879
  • HY-P2092
    Cyclo(L-leucyl-L-tryptophyl)
    		Inhibitor 99.90%
    Cyclo(L-leucyl-L-tryptophyl) (Cyclo(-Leu-Trp)) is a cyclic dipeptide that inhibits a various of bacteria and fungi. Cyclo(L-leucyl-L-tryptophyl) is a melatonin receptor agonist and is also used as a bitter ligand.
    Cyclo(L-leucyl-L-tryptophyl)
  • HY-U00249
    Saperconazole
    		Inhibitor 99.92%
    Saperconazole (R66905) is a broad-spectrum antifungal triazole and has potent activity against Aspergillus with an MIC90 of 0.19 mg/L.
    Saperconazole
  • HY-133719
    Fenfuram
    		Inhibitor 99.91%
    Fenfuram is an antifungal agent with an EC50 of 6.18 mg/mL against R. solani. Fenfuram can be used in anti-infective research.
    Fenfuram
  • HY-Y0510
    Nitrofungin
    		Inhibitor 99.82%
    Nitrofungin (2-Chloro-4-nitrophenol) is an antifungal agent, and can also be degraded by some bacteria.
    Nitrofungin
  • HY-17395AR
    Terbinafine (Standard)
    		Inhibitor
    Terbinafine (Standard) is the analytical standard of Terbinafine. This product is intended for research and analytical applications. Terbinafine (TDT 067) is an orally active and potent antifungal agent. Terbinafine is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine (Standard)
  • HY-W040305
    2,6-Dichloro-4-nitroaniline
    		Inhibitor ≥99.0%
    2,6-Dichloro-4-nitroaniline is an orally active Herbicide, Fungicide and uncoupler. 2,6-Dichloro-4-nitroaniline uncouples oxidative phosphorylation and inhibits electron transport. 2,6-Dichloro-4-nitroaniline induces biphenyl hydroxylase activity in rat liver. 2,6-Dichloro-4-nitroaniline increases the relative liver weight of rats via hepatomegaly without altering their body weight.
    2,6-Dichloro-4-nitroaniline
  • HY-B0851
    Triadimenol
    		Inhibitor 99.78%
    Triadimenol is a triazole fungicide and has been widely used in agriculture. Triadimenol has certain toxicity to animals.
    Triadimenol
  • HY-176970
    Antimicrobial agent-45
    		Inhibitor 99.59%
    Antimicrobial agent-45 (Compound 16) is a broad-spectrum antibacterial agent. Antimicrobial agent-45 exhibits MICs against Cr. neoformans, S. aureus, MRSA and My. intracellulare of 9.25, 74.04, 74.04 and 74.04 μM respectively. Antimicrobial agent-45 can be used for the study of cryptococcal infections.
    Antimicrobial agent-45
  • HY-W329835
    Fenbuconazole
    		Inhibitor ≥99.0%
    Fenbuconazole is a triazole fungicide that has fungicidal activity through inhibiting sterol biosynthesis. Fenbuconazole is an inhibitor of human aromatase activity in human choriocarcinoma JEG-3 cell line. Fenbuconazole can result in a significant increase in DNA damage in Allium cepa root cells. Fenbuconazole significantly increases the abnormal cell frequency in vitro. Fenbuconazole exhibits ED50 of 0.21 μg/mL with M.citri and 1.01 μg/mL with C. acutatum.
    Fenbuconazole
  • HY-B0842S
    Thiophanate-methyl-d6
    		Inhibitor
    Thiophanate-methyl-d6 is the deuterium labeled Thiophanate-methyl. Thiophanate-Methyl is a systematic fungicide.
    Thiophanate-methyl-d<sub>6</sub>
  • HY-N8389
    Globulol
    		Inhibitor 99.74%
    Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma.
    Globulol
  • HY-B1839R
    Fluazinam (Standard)
    		Inhibitor
    Fluazinam (Standard) is the analytical standard of Fluazinam (HY-B1839). This product is intended for research and analytical applications. Fluazinam is a broad spectrum pyridinamine fungal inhibitor. Fluazinam is an orally active dinitroaniline fungicide. Fluazinam induces phosphorylation of JNK, activates p38 pathway, decreases Bcl-2, activates caspase-3, decreases complex I activity, increases Autophagy and Apoptosis. Fluazinam has strong antifungal activity against F. fujikuroi and B. maydis. Fluazinam has a negative impact on Brachydanio rerio and worker bees.
    Fluazinam (Standard)
  • HY-W587956
    α-Guaiene
    		Inhibitor ≥99.0%
    α-Guaiene is a natural sesquiterpene and fungicidal agent found in Pogostemon cablin (patchouli) essential oil. α-Guaiene suppresses the growth of Aspergillus niger, Candida albicans, Microsporum gypseum, and Trichophyton mentagrophytes. α-Guaiene can be used for the study of fungal infection.
    α-Guaiene
  • HY-19551
    Apogossypolone
    		Inhibitor 98.58%
    Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy. Apogossypolone also has antifungal activity.
    Apogossypolone
Cat. No. Product Name / Synonyms Application Reactivity