Globulol 

Globulol is a terpenoid metabolite and Antimicrobial agent. Globulol can be isolated from Alpinia oxyphylla Miq. Globulol binds to PAK4, reduces the expression level of PAK4 in cancer cells, decreases the phosphorylation of AKT, and downregulates the expressions of STAT3, phosphorylated STAT3, and PD-L1. Globulol promotes the secretion of CCL4 by cancer cells. Globulol reduces the viability and proliferation ability of cancer cells, induces G0/G1 cell cycle arrest and Apoptosis in cancer cells, and inhibits cancer cell migration and the integrity of 3D tumor spheres. Globulol enhances the relevant effects of anti-PD-1 agents in the cancer cell microenvironment. Globulol exhibits anticancer activity against liver cancer. Globulol inhibits the mycelial growth of phytopathogenic fungi and the growth of phytopathogenic bacteria. Globulol can be used in studies related to hepatocellular carcinoma^[1][2].

Globulol (0-320 μM; 24 h) reduces the viability of Huh1 and Huh7 hepatocellular carcinoma cells in a concentration-dependent manner, with IC₅₀ values of 136.6 μM and 141.5 μM, respectively^[1].
Globulol (40-120 μM; 24 h) induces G₀/G₁ cell cycle arrest in Huh1 and Huh7 hepatocellular carcinoma cells^[1].
Globulol (40-120 μM) induces apoptosis in Huh1 and Huh7 hepatocellular carcinoma cells in a dose-dependent manner^[1].
Globulol (40-120 μM; 12 h) inhibits the migratory capacity of Huh1 and Huh7 hepatocellular carcinoma cells in 3D tumor spheroid models^[1].
Globulol (80 μM) enhances the migratory capacity of activated CD8⁺ T cells toward Huh1 and Huh7 hepatocellular carcinoma cells by upregulating the expression of CCL4 during a 24-hour co-cultivation process^[1].
Globulol (80 μM; 24 h) enhances CD8⁺ T cell-mediated cytotoxicity against 3D spheroids of Huh7 hepatocellular carcinoma cells during a 24-hour co-culture process^[1].
Globulol (40-120 μM) inhibits the PAK4-pAKT-STAT3 pathway and reduces the expression of PD-L1 protein in wild-type, PAK4-overexpressing and PAK4-knockdown Huh7 hepatocellular carcinoma cells^[1].
Globulol inhibits the growth of Xanthomonas vesicatoria and Bacillus subtilis, with an IC₅₀ of 158.0 μg mL⁻¹ against the former and 737.2 μg mL⁻¹ against the latter^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

222.37

C₁₅H₂₆O

489-41-8

Solid

White to off-white

CC1([C@@]2([H])[C@@]3([H])[C@](CC[C@H]3C)([H])[C@](O)(CC[C@]21[H])C)C

Room temperature in continental US; may vary elsewhere.

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

• [1]. Wang Z, et al. Globulol from Alpinia oxyphylla Miq. Enhances the pharmacological effects of anti-PD-1 drugs in combination by reducing PD-L1 expression in hepatocellular carcinoma. Front Pharmacol. 2026 Feb 20;17:1728692.

  [2]. Tan M, et al. Antimicrobial activity of globulol isolated from the fruits of Eucalyptus globulus Labill. Nat Prod Res. 2008 May 10;22(7):569-75.  [Content Brief]