1. Apoptosis
    Autophagy
    Anti-infection
    Protein Tyrosine Kinase/RTK
  2. Bcl-2 Family
    Apoptosis
    Autophagy
    Fungal
    ROS Kinase
  3. Apogossypolone

Apogossypolone  (Synonyms: ApoG2)

Cat. No.: HY-19551
Handling Instructions

Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis and autophagy. Apogossypolone also has antifungal activity.

For research use only. We do not sell to patients.

Apogossypolone Chemical Structure

Apogossypolone Chemical Structure

CAS No. : 886578-07-0

Size Stock
100 mg   Get quote  
250 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

Top Publications Citing Use of Products

View All Bcl-2 Family Isoform Specific Products:

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Apogossypolone (ApoG2) is an orally active Bcl-2 family proteins inhibitor with Ki values of 35, 25 and 660 nM for Bcl-2, Mcl-1 and Bcl-XL, respectively. Apogossypolone shows antitumor activities, induces cell apoptosis[1] and autophagy[2]. Apogossypolone also has antifungal activity[3].

IC50 & Target

Mcl-1

25 nM (Ki)

Bcl-2

35 nM (Ki)

Bcl-xL

660 nM (Ki)

In Vitro

Apogossypolone (ApoG2) shows improved stability under stressed conditions[1].
Apogossypolone (0-1 µM, 72 or 96 h) inhibits WSU-DLCL2 cells growth in a dose-dependent manner[1].
Apogossypolone (0-5 µM, 24 or 48 h) interferes with the formation of heterodimers between anti-apoptotic and pro-apoptotic Bcl-2 family members, and leads to cleavage of caspase-3, caspase-9 and PARP[1].
Apogossypolone (0-8 µM, 0-72 h) induces apoptotic WSU-DLCL2 cell death in a time- and dose-dependent manner[1].
Apogossypolone (0-10 µM, 0-24 h) induces autophagy and promotes ROS generation in HCC cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[1]

Cell Line: WSU-DLCL2
Concentration: 250, 350, 500 and 1000 nM
Incubation Time: 96 h for cell counting, 72 h for MTT
Result: Inhibited growth in a dose-dependent manner. The 50% growth inhibition concentration (IC50) was approximately 350 nM.

Western Blot Analysis[1]

Cell Line: WSU-DLCL2
Concentration: 0.35, 0.5, 1 and 5 µM
Incubation Time: 24 or 48 h
Result: Blocked the formation of heterodimers between Bcl-XL and Bim in a concentration-dependent manner. Resulted in the activation of cleavages of caspase-3, caspase-9 and PARP.

Apoptosis Analysis[1]

Cell Line: WSU-DLCL2
Concentration: 0, 1, 2, 4 and 8 µM
Incubation Time: 24, 48 and 72 h
Result: Induced cell apoptosis in a time- and dose-dependent manner.

Cell Autophagy Assay[2]

Cell Line: HepG2 and Hep3B
Concentration: 1.25, 2.5, 5 and 10 µM
Incubation Time: 6, 12, 18 and 24 h
Result: Induced LC3 (Light chain 3)-II conversion in a dose- and time-dependent manner.
In Vivo

Apogossypolone (ApoG2) (120 mg/kg; i.v. or p.o.; once a day for 5 days) effectively inhibits growth of diffuse large cell lymphoma cells without toxicity[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Four-week-old female ICR-SCID mice, each mouse received 107 WSU-DLCL2 cells (in serum-free RPMI 1640) subcutaneously (sc) in each flank area[1]
Dosage: 120 mg/kg
Administration: Intravenous or administration per day for five days
Result: Inhibited the growth of WSU-DLCL2 and significantly decreased the tumor weight.
Animal Model: Non-tumor-bearing SCID mice[1]
Dosage: 160 mg/kg
Administration: Intravenous or administration per day for five days
Result: Was well tolerated in mice up to 800 mg/kg. Displayed no gross signs of toxicity.
Molecular Weight

490.50

Formula

C28H26O8

CAS No.
SMILES

O=C1C(C(C2=O)=C(C)C(C3=C2C=C(O)C(O)=C3C(C)C)=O)=C(C)C(C4=C1C=C(O)C(O)=C4C(C)C)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

 

Salutation

Applicant Name *

 

Email address *

Phone number *

 

Organization name *

Department *

 

Requested quantity *

Country or Region *

     

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Apogossypolone
Cat. No.:
HY-19551
Quantity:
MCE Japan Authorized Agent: