2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0105S
    Ketoconazole-d8
    		Inhibitor 99.79%
    Ketoconazole-d8 is the deuterium labeled Ketoconazole. Ketoconazole (R-41400) is an imidazole anti-fungal agent, a CYP3A4 and CYP24A1 inhibitor.
    Ketoconazole-d<sub>8</sub>
  • HY-W774934
    Isopyrazam
    		Inhibitor
    Isopyrazam is a plant protection product with fungal activity. Isopyrazam exhibits excellent disease resistance on crops and effectively inhibits the growth of multiple plant pathogenic fungi. The application of Isopyrazam can significantly improve the yield and quality of crops.
    Isopyrazam
  • HY-108938
    SDZ285428
    		Inhibitor 98.00%
    SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 <1 (5 min) and I/E2=9 (1 h). SDZ285428 inhibits Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h).
    SDZ285428
  • HY-N12697A
    Polycarpine hydrochloride
    		Inhibitor 98.05%
    Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively.
    Polycarpine hydrochloride
  • HY-77173
    Demethoxyencecalin
    		Inhibitor 99.25%
    Demethoxyencecalin is a chromene isolated from Helianthus annuus, has antifungal activities.
    Demethoxyencecalin
  • HY-33037R
    Phenazine-1-carboxylic acid (Standard)
    		Inhibitor
    Phenazine-1-carboxylic acid (Standard) is the analytical standard of Phenazine-1-carboxylic acid. This product is intended for research and analytical applications. Phenazine-1-carboxylic acid is an antifungal agent. Additionally, Phenazine-1-carboxylic acid exhibits anticancer activity by inducing apoptosis in cancer cells through the regulation of ROS generation. Phenazine-1-carboxylic acid can upregulate the expression of IL-8 and ICAM-1 while inhibiting the release of RANTES and MCP-1, demonstrating its potential immunomodulatory effects. Phenazine-1-carboxylic acid holds significant research value in the areas of anti-infection, anticancer, and immune response modulation[1][2][3][4].
    Phenazine-1-carboxylic acid (Standard)
  • HY-W040156
    Oxadixyl
    		Inhibitor
    Oxadixyl is a fungicide with activity that inhibits the growth of fungi. Oxadixyl was tested during the malic fermentation of red wine, where its concentration may be affected. The biological activity of Oxadixyl helps to evaluate its effect on microorganisms during the winemaking process.
    Oxadixyl
  • HY-N2446
    Kakuol
    		Inhibitor 99.96%
    Kakuol is a natural compound with antifungal activity.
    Kakuol
  • HY-P1508A
    Bactenecin TFA
    		Inhibitor 98.02%
    Bactenecin TFA (Bactenecin, bovine TFA) is a potent 12-aa looped antimicrobial peptide isolated from bovine neutrophils. Bactenecin TFA inhibits the growth of bacteria and yeast, and kills the fungus Trichophyton rubrum. Bactenecin TFA increass membrane permeability, inhibits the growth and biofilm formation of B. pseudomallei.
    Bactenecin TFA
  • HY-W010435R
    Sulcatone (Standard)
    		Inhibitor
    Sulcatone (Standard) (6-Methyl-5-hepten-2-one (Standard)) is the analytical standard of Sulcatone (HY-W010435). This product is intended for research and analytical applications. Sulcatone (6-Methyl-5-hepten-2-one) is a plant-derived volatile organic compound with activities such as insecticidal, antifungal, and blood pressure-lowering effects. Sulcatone also serves as an insect pheromone and an endogenous metabolite, which can be found in feces. Changes in Sulcatone levels can be used for the auxiliary diagnosis of ulcerative colitis.
    Sulcatone (Standard)
  • HY-118893
    Asukamycin
    		Inhibitor
    Asukamycin, a manumycin-type metabolite, could be isolated from Streptomyces nodosus subsp. asukaensis. Asukamycin is an antibiotic and has antimicrobial activity. Asukamycin inhibits growth of various tumor cell lines.
    Asukamycin
  • HY-17518A
    (S,S)-Valifenalate
    		Inhibitor 98.0%
    (S,S)-Valifenalate ((S,S)-IR5885) is an acylamino acid fungicide and is used to control a wide range of fungi belonging to the class of Oomycetes. (S,S)-Valifenalate ((S,S)-IR5885) interferes with the cell-wall synthesis thus affecting the growth stages of the pathogens controlled, both outside (on the spores) or inside the plant (on the mycelium).
    (S,S)-Valifenalate
  • HY-N11772
    Mutanocyclin
    		Inhibitor 99.94%
    Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse.
    Mutanocyclin
  • HY-N0756A
    (-)-Bornyl acetate
    		Inhibitor
    (-)-Bornyl acetate (L-(-)-Bornyl acetate), isolated from hyssop oil, is a less active enantiomer of (+)-Bornyl acetate. (-)-Bornyl acetate possesses antifungal activity.
    (-)-Bornyl acetate
  • HY-N10418
    Isorhapontin
    		Inhibitor 98.51%
    Isorhapontin is an antifungal agent. Isorhapontin inhibits the hydrolytic activity of Trichoderma cellobiohydrolase I (CBH I) with a Ki of 57.2 μM. Isorhapontin also inhibits the activity of Trichoderma endoglucanase I.
    Isorhapontin
  • HY-137794
    Tetramethylkaempferol
    		Inhibitor 99.93%
    Tetramethylkaempferol is an antifungal agent. Tetramethylkaempferol shows antifungal activity against Candida albicansCandida albicans with an IC50 value of 17.63 µg/mL.
    Tetramethylkaempferol
  • HY-123691
    7-O-Demethyl rapamycin
    		Inhibitor
    7-O-Demethyl rapamycin, a derivative of Rapamycin (HY-10219), has antifungal activity and immunosuppressant properties. 7-O-Demethyl rapamycin has useful tumor cell growth-inhibiting activity.
    7-O-Demethyl rapamycin
  • HY-W739754
    Ergosterol acetate
    		98.23%
    Ergosterol acetate is a natural compound that can be isolated from fungi.
    Ergosterol acetate
  • HY-135761R
    Penconazole (Standard)
    		Inhibitor
    Penconazole (Standard) is the analytical standard of Penconazole. This product is intended for research and analytical applications. Penconazole is a typical triazole fungicide, and mainly applied on apples, grapes, and vegetables to control powdery mildew. Penconazole inhibits sterol biosynthesis in fungi. Penconazole decrease AChE activity in the cerebrum and cerebellum of rats.
    Penconazole (Standard)
  • HY-136461
    Polyoxin D
    		Inhibitor 99.92%
    Polyoxin D (Polyoxorim), a polyoxin antibiotic fungicide, is a potent chitin synthetase inhibitor.
    Polyoxin D
Cat. No. Product Name / Synonyms Application Reactivity