Polycarpine hydrochloride
Based on 1 Customer Validation
Polycarpine hydrochloride (1a) is a broad-spectrum Mpro inhibitor (IC50 = 30 nM) that can be isolated from the Polycarpa aurata and also serves as an anti-coronaviral agent. Polycarpine hydrochloride possesses antiviral and antifungal activities, with IC50 values of 30.0 nM and 0.12 μM against SARS-CoV-2 Mpro and PEDV Mpro, respectively.
For research use only. We do not sell to patients.
- Purity: 98.05%
- CAS No.: 175669-29-1
- Formula: C22H26Cl2N6O2S2
- Molecular Weight:541.52
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
IC50: 30 nM (Mpro)[1].
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| Vero C1008 | CC50 |
50.2 μM
Compound: 1a
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Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability
Cytotoxicity against African green monkey Vero E6 cells assessed as reduction of cell viability
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[PMID: 38508325] |
Chemical Information
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CAS No. 175669-29-1
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Appearance Solid
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Molecular Weight 541.52
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Formula C22H26Cl2N6O2S2
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Color Yellow to orange
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SMILES
COC1=CC=C(C=C1)C2=C(N(C(N)=N2)C)SSC3=C(N=C(N3C)N)C4=CC=C(C=C4)OC.Cl.Cl
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Structure Classification
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Initial Source
Polycarpa aurata
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 83.33 mg/mL (153.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (277 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8467 mL | 9.2333 mL | 18.4665 mL | 46.1663 mL |
| 5 mM | 0.3693 mL | 1.8467 mL | 3.6933 mL | 9.2333 mL | |
| 10 mM | 0.1847 mL | 0.9233 mL | 1.8467 mL | 4.6166 mL | |
| 15 mM | 0.1231 mL | 0.6156 mL | 1.2311 mL | 3.0778 mL | |
| 20 mM | 0.0923 mL | 0.4617 mL | 0.9233 mL | 2.3083 mL | |
| 25 mM | 0.0739 mL | 0.3693 mL | 0.7387 mL | 1.8467 mL | |
| 30 mM | 0.0616 mL | 0.3078 mL | 0.6156 mL | 1.5389 mL | |
| 40 mM | 0.0462 mL | 0.2308 mL | 0.4617 mL | 1.1542 mL | |
| 50 mM | 0.0369 mL | 0.1847 mL | 0.3693 mL | 0.9233 mL | |
| 60 mM | 0.0308 mL | 0.1539 mL | 0.3078 mL | 0.7694 mL | |
| 80 mM | 0.0231 mL | 0.1154 mL | 0.2308 mL | 0.5771 mL | |
| 100 mM | 0.0185 mL | 0.0923 mL | 0.1847 mL | 0.4617 mL |
Polycarpine hydrochloride Related Classifications
HY-N12697A Related Classifications
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