Mutanocyclin
Based on 1 Customer Validation
Mutanocyclin is a potent antifungal agent. Mutanocyclin inhibits Candida albicans (C. albicans) filamentation. Mutanocyclin decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1. Mutanocyclin inhibits yeast-form in ex vivo mouse.
For research use only. We do not sell to patients.
- Purity: 99.94%
- CAS No.: 875455-92-8
- Formula: C10H15NO3
- Molecular Weight:197.23
-
Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Biological Activity
-
Chemical Information
-
Solvent & Solubility
- Purity & Documentation
- References
-
Help & FAQs
-
Anti-Infection Compound Library
HY-L002
-
Natural Product Library
HY-L021
-
Antifungal Compound Library
HY-L048
-
Microbial Metabolite Library
HY-L084
-
Bioactive Compound Library Max
HY-L181
-
MCE Bioactive Compound Library
HY-L001V
-
Natural Product Library Plus
HY-L021P
-
Natural Product and Natural Product-Like Compound Library
HY-L021M
-
Bioactive Compound Library
HY-L001
-
RO5 Drug-like Natural Product Library
HY-L200
-
High-Throughput Bioactive Compound Library
HY-L205
-
High-Throughput Natural Product Library
HY-L206
-
Bacteria-Sourced Compound Library
HY-L254
-
Mass Spectrometry Natural Product Library
HY-L262
Biological Activity
Mutanocyclin (8, 16, 32 µg/mL, 24, 36 h) inhibits Candida albicans (C. albicans) filamentation in a dose-dependent manner[1].
Mutanocyclin (32 µg/mL) decreases the mRNA expression of HWP1, ECE1, FLO8, TEC1 in C. albicans cells[1].
Mutanocyclin functions by regulating the PKA catabolic subunit Tpk2 and its preferential binding target Sfl1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Mutanocyclin (6.4, 12.8, 25.6 µg/mL; 48 h) attenuates the virulence of C. albicans in the G. mellonella infection model[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 875455-92-8
-
Appearance Solid
-
Molecular Weight 197.23
-
Formula C10H15NO3
-
Color White to off-white
-
SMILES
O=C1[C@@H](CC(C)C)NC(O)=C1C(C)=O
-
Structure Classification
-
Initial Source
Streptococcus mutans
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 50 mg/mL (253.51 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2 mg/mL (10.14 mM); Clear solution
This protocol yields a clear solution of ≥ 2 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
-
-
-
-
Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
-
%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
-
%+
-
+%Tween-80 + +
-
%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
-
Data Sheet (275 KB)
-
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
-
Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.0702 mL | 25.3511 mL | 50.7022 mL | 126.7556 mL |
| 5 mM | 1.0140 mL | 5.0702 mL | 10.1404 mL | 25.3511 mL | |
| 10 mM | 0.5070 mL | 2.5351 mL | 5.0702 mL | 12.6756 mL | |
| 15 mM | 0.3380 mL | 1.6901 mL | 3.3801 mL | 8.4504 mL | |
| 20 mM | 0.2535 mL | 1.2676 mL | 2.5351 mL | 6.3378 mL | |
| 25 mM | 0.2028 mL | 1.0140 mL | 2.0281 mL | 5.0702 mL | |
| 30 mM | 0.1690 mL | 0.8450 mL | 1.6901 mL | 4.2252 mL | |
| 40 mM | 0.1268 mL | 0.6338 mL | 1.2676 mL | 3.1689 mL | |
| 50 mM | 0.1014 mL | 0.5070 mL | 1.0140 mL | 2.5351 mL | |
| 60 mM | 0.0845 mL | 0.4225 mL | 0.8450 mL | 2.1126 mL | |
| 80 mM | 0.0634 mL | 0.3169 mL | 0.6338 mL | 1.5844 mL | |
| 100 mM | 0.0507 mL | 0.2535 mL | 0.5070 mL | 1.2676 mL |
Mutanocyclin Related Classifications
HY-N11772 Related Classifications
Powered by Bioz