2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-A0148
    Halofantrine
    		Inhibitor
    Halofantrine (SKF-102886 hydrochloride; WR-171669 hydrochloride) is a blocker that delays the delayed rectifier potassium current by inhibiting human ERG channels, and it is a potent antimalarial agent with oral activity. Halofantrine inhibits the Cap1-dependent oxidative stress response of Candida albicans, suppresses ROS responses, and enhances the antifungal (Fungal) activity of oxidative damage agents. Halofantrine exhibits antifungal activity in the Galleria mellonella model, and shows antimalarial activity against Plasmodium strains both in vitro and in animal models. Halofantrine can be used in studies related to invasive candidiasis, falciparum malaria, and vivax malaria.
    Halofantrine
  • HY-N10101
    Eriobofuran
    		Inhibitor
    Eriobofuran is an antifungal agent can be isolated from Sorbus aucuparia.
    Eriobofuran
  • HY-178732
    AB-22
    		Inhibitor
    AB-22, a vinyl sulfate compound, is an orally active antifungal agent. AB-22 inhibits hyphal growth and biofilm initiation by inhibiting the gene expression of ALS3, HWP1, and ECE1 in Candida albicans SC5314 cells. AB-22 can be used for the research of infrction, such as systemic candidiasis.
    AB-22
  • HY-155700
    SDH-IN-6
    		Inhibitor
    SDH-IN-6 (compound 6i) is a potent succinate dehydrogenase (SDH) inhibitor. SDH-IN-6 has antifungal activity against Valsa mali with an EC50 value of 1.77 mg/L.
    SDH-IN-6
  • HY-156252
    Antifungal agent 75
    		Inhibitor
    Antifungal agent 75 (compound 6r) is a potent antifungal agent against Candida albicans. Antifungal agent 75 significantly inhibits the formation of C. albicans biofilm, increases the permeability of the cell membrane, reduces the ergosterol level of the cell membrane, damages the membrane structure, and destroys the integrity of the cell structure to exert excellent antifungal activity.
    Antifungal agent 75
  • HY-P2890B
    Laccase, Trametes versicolor
    Laccase, Trametes versicolor (EC 1.10.3.2), is a blue copper oxidase that reduces molecular oxygen to water. Laccase can oxidize polyphenols, methoxylated phenolic compounds, and diamines, but not tyrosine. Laccase's oxidation reaction is a single-electron reaction and produces free radicals.
    Laccase, Trametes versicolor
  • HY-N19506
    Vincadifformine N(4)-oxide
    Vincadifformine N (4)-oxide is a monoterpenoid indole alkaloid. Vincadifformine N (4)-oxide can be isolated from Rhazya stricta. Vincadifformine N (4)-oxide shows a MIC > 50 μg/mL against tested Candida strains and exhibits no antifungal activity.
    Vincadifformine N(4)-oxide
  • HY-169202
    Antifungal agent 118
    		Inhibitor
    Antifungal agent 118 (compund C22) inhibits the hyphal growth of V. mali by inducing oxidative damage and disrupting the integrity of the cell membrane.
    Antifungal agent 118
  • HY-N17442
    Echinoside A
    		Inhibitor
    Echinoside A is a saponin. Echinoside A can be isolated from sea cucumber. Echinoside A inhibits the catalytic activity of Top2α, reduces the noncovalent binding of Top2α to DNA. Echinoside A activates Caspase-3 and induces PARP cleavage. Echinoside A induces Apoptosis. Echinoside A has anticancer activity against prostate cancer, hepatocellular carcinoma, and S-180 sarcoma. Echinoside A exhibits antifungal activity against a variety of fungi, with a minimum growth inhibitory concentration range of 3.12 to 50.0 μg/mL, including potent activity against Aspergillus and Penicillium species.
    Echinoside A
  • HY-D2977
    AF-1
    		Inhibitor
    AF-1 is a azole-based near-infrared fluorescence diagnostic probe with an emission wavelength of 632 nm. AF-1 selectively accumulates in fungal cell membranes at physiological pH. AF-1 targets and induces Autophagy. AF-1 exhibits antifungal activity and sensitivity to autophagy-related pH.
    AF-1
  • HY-149653
    SDH-IN-10
    		Inhibitor
    SDH-IN-10 is a potent succinate dehydrogenase inhibitor (SDHI) with antifungal effects.
    SDH-IN-10
  • HY-125666
    Agistatin B
    Agistatin B, isolated from fungus, is a mycotoxin. Agistatin B inhibits cholesterol synthesis.
    Agistatin B
  • HY-N10293
    Monaschromone
    		Inhibitor
    Monaschromone, a polyketide metabolite, significantly inhibits the growth of B. cinerea, A. solani, M. oryzae, and G. saubinettii, with the MIC values ranging from 6.25 to 12.5 μM.
    Monaschromone
  • HY-129208
    Viridicatumtoxin
    		Inhibitor
    Viridicatumtoxin is a new mycotoxin extracted from Penicillium viridicatum with a LD50 of 122.4 mg/kg in rats.
    Viridicatumtoxin
  • HY-146427
    Antifungal agent 29
    		Inhibitor
    Antifungal agent 29 (compound 9d) is a potent, selective and non-toxic antifungal agent. Antifungal agent 29 shows antifungal activity towards Cryptococcus neoformans (MIC ≤ 0.23 μM).
    Antifungal agent 29
  • HY-145348
    MK-5204
    		Inhibitor
    MK-5204 is an orally active β-1,3-glucan synthesis inhibitor.
    MK-5204
  • HY-122785
    Fusapyrone
    		Inhibitor
    Fusapyrone is a broad-spectrum antifungal metabolite first isolated from Fusarium species. It has been investigated for use in the control of postharvest crop diseases such as inhibiting the growth of ochratoxin-producing strains of Aspergillus section Nigri in wine grapes.
    Fusapyrone
  • HY-139905
    Antifungal agent 19
    		Inhibitor
    Antifungal agent 19 shows the potent antifungal activity (EC50 = 0.72 μM).
    Antifungal agent 19
  • HY-N10958
    Wikstrol A
    		Inhibitor
    Wikstrol A is a potent antifungal, antimitotic and anti-HIV-1 Agent. Wikstrol A induces morphological deformation of P. oryzae mycelia with an MMDC value of 70.1 µM. Wikstrol A shows activity against microtubule polymerization with an IC50 value of 131 µM. Wikstrol A shows anti-HIV-1 activity with an IC50 value of 67.8 µM.
    Wikstrol A
  • HY-163284
    SDH-IN-12
    SDH-IN-12 (compound 9b) is a succinate dehydrogenase inhibitor, which exhibits activity against S. sclerotiorum and C. arachidicola, with EC50s of 0.97 and 2.07 μM, respectively. SDH-IN-12 reveals no significant herbicidal activity against monocotyledonous and dicotyledonous plants.
    SDH-IN-12
Cat. No. Product Name / Synonyms Application Reactivity