1. Anti-infection
    Membrane Transporter/Ion Channel
  2. Parasite
    Potassium Channel
  3. Halofantrine

Halofantrine  (Synonyms: SKF-102886 free base; WR-171669)

Cat. No.: HY-A0148
Handling Instructions

Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum. Halofantrine blocks HERG potassium channels.

For research use only. We do not sell to patients.

Halofantrine Chemical Structure

Halofantrine Chemical Structure

CAS No. : 69756-53-2

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Halofantrine (SKF-102886 free base) is a highly lipophilic antimalarial active against Chloroquine-resistant strains of Plasmodium falciparum[1]. Halofantrine blocks HERG potassium channels[2].

In Vitro

Halofantrine blocks HERG tail currents elicited on repolarization to 760 mV from +30 mV with an IC50 of 196.9 nM[2].
Halofantrine inhibits MDA-MB-231 triple-negative breast cancer (TNBC) cell proliferation with the IC50 of 7.73±0.23 μM[3].
Halofantrine exhibits activity against asexual forms (3D7A), asexual forms (3D7HT-GFP), and mature gametocytes IV-V with IC50s of 0.0011, 0.0012, and 6.70 μM, respectively[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[3]

Cell Line: MDA-MB-231 TNBC
Concentration: 0, 2.50, 5.00, 10.00, 20.00, 40.00, and 80.00 μM
Incubation Time: 3 days
Result: IC50 was 7.73±0.23 μM.
Molecular Weight







Room temperature in continental US; may vary elsewhere.


Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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