2. Signaling Pathways
  3. Anti-infection
  4. Fungal

Fungal

Fungal

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An antifungal agent is a drug that selectively eliminates fungal pathogens from a host with minimal toxicity to the host.

Classes: 1. Polyene Antifungal Drugs: Amphotericin, nystatin, and pimaricin interact with sterols in the cell membrane (ergosterol in fungi, cholesterol in humans) to form channels through which small molecules leak from the inside of the fungal cell to the outside. 2. Azole Antifungal Drugs: Fluconazole, itraconazole, and ketoconazole inhibit cytochrome P450-dependent enzymes (particularly C14-demethylase) involved in the biosynthesis of ergosterol, which is required for fungal cell membrane structure and function. 3. Allylamine and Morpholine Antifungal Drugs: lylamines (naftifine, terbinafine) inhibit ergosterol biosynthesis at the level of squalene epoxidase. The morpholine drug, amorolfine, inhibits the same pathway at a later step. 4. Antimetabolite Antifungal Drugs: 5-Fluorocytosine acts as an inhibitor of both DNA and RNA synthesis via the intracytoplasmic conversion of 5-fluorocytosine to 5-fluorouracil.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B1360R
    Chlorquinaldol (Standard)
    		Inhibitor
    Chlorquinaldol (Standard) is the analytical standard of Chlorquinaldol. This product is intended for research and analytical applications. Chlorquinaldol (Chloquinan) is an antibacterial agent with the potential use in topical skin conditions and vaginal infections. Chlorquinaldol is a β-catenin/TCF4 inhibitor, showing anti-proliferation, anti-migration, and apoptosis-inducing activity in cancer cells.
    Chlorquinaldol (Standard)
  • HY-B0101A
    Fluconazole hydrate
    		Inhibitor
    Fluconazole (hydrate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.
    Fluconazole hydrate
  • HY-N0444R
    Rubiadin (Standard)
    		Inhibitor
    Rubiadin (Standard) is the analytical standard of Rubiadin. This product is intended for research and analytical applications. Rubiadin is a dihydroxy anthraquinone isolated from Rubia cordifolia. Rubiadin has a potent antixidant activity.
    Rubiadin (Standard)
  • HY-17518R
    Valifenalate (Standard)
    		Inhibitor
    Valifenalate (Standard) is the analytical standard of Valifenalate. This product is intended for research and analytical applications. Valifenalate (IR5885; Valiphenal) is an insecticide agent and fungicide, which is approved for application on high-value crops such as grapes, tomatoes and other vegetables. Valifenalate interferes with cell-wall synthesisValifenalate is effective against various types of mildew. Valifenalate can be used against crown rot of rose cuased by Phytophthora citrophthora. Valifenalate induces non-adverse thyroid changes via adaptive induction of uridine 5’-diphosphoglucuronosyltransferase (UGT) in the liver of dogs and rats.
    Valifenalate (Standard)
  • HY-N1300
    Shizukanolide F
    		Inhibitor
    Shizukanolide F is a dimeric sesquiterpene, which is derivated from Chloranthus japonicus Sieb. Shizukanolide F exhibits potent antifungal activities against various plant pathogenic fungi and anti-metastasis breast cancer.
    Shizukanolide F
  • HY-N14666
    Agrocybin
    		Inhibitor
    Agrocybin is an antifungal peptide that exerts antifungal activity against several fungal species but lacks inhibitory activity against bacteria. Agrocybin attenuates the activity of HIV-1 reverse transcriptase.
    Agrocybin
  • HY-162615
    Antibacterial agent 225
    		Inhibitor
    Antibacterial agent 225 (compound 12a-2) simultaneously exerts excellent bifunctional effects of fungal inhibition and immune activation.
    Antibacterial agent 225
  • HY-B0301R
    Bifonazole (Standard)
    		Inhibitor
    Bifonazole (Standard) is the analytical standard of Bifonazole. This product is intended for research and analytical applications. Bifonazole (Bay H-4502) is an imidazole antifungal agent.
    Bifonazole (Standard)
  • HY-W320538
    Benz[g]isoquinoline-5,10-dione
    		Inhibitor
    Benz[g]isoquinoline-5,10-dione, an active component isolated from the ethanolic extract of the aerial parts of Mitracarpus scaber, demonstrates notable in vitro inhibitory activity against AIDS-related pathogens, along with significant antibacterial and antifungal properties, as evidenced by the agar well-diffusion assay.
    Benz[g]isoquinoline-5,10-dione
  • HY-121214
    Amisulbrom
    		Inhibitor 99.92%
    Amisulbrom is a sulfonamide fungicide used to control oomycete diseases. Amisulbrom inhibits the cytochrome-bc1 complex of the mitochondrial electron transport system.
    Amisulbrom
  • HY-N14195
    Mathemycin A
    		Inhibitor
    Mathemycin A has an inhibitory effect on pathogenic fungi. Mathemycin A inhibits the Phytophthora infestans JO8 in vitro (MIC is 7.8 μg/mL), and it inhibits JO8 in greenhouse (LD50 is 42 X 10-6, LC90 is 500 X 10-6).
    Mathemycin A
  • HY-N14248
    Melithiazole A
    		Inhibitor
    Melithiazol A is an antibiotic. Melithiazole A is a β-methoxyacrylate (MOA) inhibitor with strong anti-agent activity. Antifungal and cytotoxic agent.
    Melithiazole A
  • HY-17395R
    Terbinafine hydrochloride (Standard)
    		Inhibitor
    Terbinafine hydrochloride (Standard) is the analytical standard of Terbinafine hydrochloride. This product is intended for research and analytical applications. Terbinafine hydrochloride (TDT 067 hydrochloride) is an orally active and potent antifungal agent. Terbinafine hydrochloride is a potent non-competitive inhibitor of squalene epoxidase from Candida, with a Ki of 30 nM. Terbinafine hydrochloride also shows antibacterial activity against certain Gram-positive and Gram-negative bacteria. Terbinafine hydrochloride is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Terbinafine hydrochloride (Standard)
  • HY-N13999
    Clavamycin D
    		Inhibitor
    Clavamycin D has strong anti-candida activity, and its action can be antagonized by dipeptide or tripeptide, but amino acid can not cancel its action. No antibacterial activity and no inhibition of β-lactamase.
    Clavamycin D
  • HY-171795
    Isolubimin
    		Inhibitor
    Isolubimin is a sesquiterpenoid phytoalexin found in Datura stramonium fruits with antibacterial activity. Isolubimin is promising for research of plant disease caused by fungal infections.
    Isolubimin
  • HY-14282R
    Lanoconazole (Standard)
    		Inhibitor
    Lanoconazole (Standard) is the analytical standard of Lanoconazole. This product is intended for research and analytical applications. Lanoconazole is a potent and orally active imidazole antifungal agent, shows a broad spectrum of activity against fungi in vitro and in vivo. Lanoconazole interferes with ergosterol biosynthesis by inhibiting sterol 14-alpha demethylase and blocking fungal membrane ergosterol biosynthesis. Lanoconazole can be used for the investigation of dermatophytosis and onychomycosis.
    Lanoconazole (Standard)
  • HY-181101
    Antifungal agent 151
    		Inhibitor
    Antifungal agent 151 is a Prp8 intein inhibitor that inhibits the self-splicing process of the Prp8 intein, preventing maturation of the Prp8 protein. Antifungal agent 151 exerts in vitro antifungal activity against Cryptococcus neoformans and Cryptococcus gattii. Antifungal agent 151 can be used for the research of cryptococcus pneumonia.
    Antifungal agent 151
  • HY-N12893
    Sclerodione
    		Inhibitor
    Sclerodione is a metabolite that can be produced by the Scleroderris canker fungus, Gremmeniellaabietina. Sclerodione has antifungal activity. Sclerodione is a lipase inhibitor (IC50: 1 μM).
    Sclerodione
  • HY-N14857
    Kanchanamycin C
    		Inhibitor
    Kanchanamycin C has anti-Gram positive and negative bacteria, yeast and filamentous fungus action.
    Kanchanamycin C
  • HY-B0537R
    Pentamidine (Standard)
    		Inhibitor
    Pentamidine (Standard) is the analytical standard of Pentamidine. This product is intended for research and analytical applications. Pentamidine (MP-601205) is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities.
    Pentamidine (Standard)
Cat. No. Product Name / Synonyms Application Reactivity