Fluconazole hydrate
Based on 21 publication(s) in Google Scholar
Fluconazole (UK-49858) hydrate is a triazole antifungal agent with excellent activities against a broad range of fungi, especially against Candida albicans. Fluconazole hydrate inhibits C. albicans and Candida kefyr with IC99s range from 0.20 μg/mL to 0.39 μg/mL.
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- CAS No.: 155347-36-7
- Formule: C13H14F2N6O2
- Masse moléculaire:324.29
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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- Références
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Publications Citing Use of MedChemExpress (MCE) Fluconazole hydrate
More- Signal Transduct Target Ther. 2025 Dec 15;10(1):406. [Abstract]
- Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]
- J Hazard Mater. 2021 Aug 15:416:125764. [Abstract]
- Environ Int. 2019 Jun:127:694-703. [Abstract]
- Antioxidants (Basel). 2025 Aug 25;14(9):1046. [Abstract]
- Environ Pollut. 2024 Aug 15:355:124214. [Abstract]
- J Agric Food Chem. 2022 Mar 2;70(8):2520-2528. [Abstract]
- Microb Biotechnol. 2022 Feb;15(2):482-498. [Abstract]
- Transl Res. 2022 Sep:247:39-57. [Abstract]
- Front Microbiol. 2025 Sep 3:16:1648467. [Abstract]
- Probiotics Antimicrob Proteins. 2026 Jan 6. [Abstract]
- Microchem J. 2026 Mar 27.
- Microbiol Spectr. 2025 May 6;13(5):e0318524. [Abstract]
- Bioorg Med Chem. 2021 Aug 15:44:116293. [Abstract]
- Drug Test Anal. 2021 Feb;13(2):283-298. [Abstract]
- J Mycol Med. 2022 Mar;32(1):101227. [Abstract]
- Open Life Sci. 2025 Apr 29;20(1):20221062. [Abstract]
- Eur J Drug Metab Pharmacokinet. 2022 Sep;47(5):639-652. [Abstract]
- University of Szeged. 2026.
- Orebro University. 2024.
- bioRxiv. 2024 May 14.
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Activité biologique
Description
In Vitro
Fluconazole hydrate inhibits 4 species ofAspergillus fumigatus with the IC50s of 23.9-43.5 μg/mL. Fluconazole (0.20 μg/mL) hydrate inhibits significantly the mycelial-phase growth and germ tube elongation of C. albicans in a medium supplemented with serum[1].
Fluconazole hydrate is a triazole antifungal agent that has been available for the treatment of infections due to Candida, Cryptococcus. The MIC90 is highest for C. krusei (MIC ≥ 64 μg/mL) and C. glabrata (MIC, 32 μg/mL) and is ≤2 μg/mL for C. albicans (0.5 μg/mL), C. parapsilosis (2 μg/mL), C. tropicalis (2 μg/mL), C. lusitaniae (2 μg/mL), and C. kefyr (0.5 μg/mL)[2].
Fluconazole (0.1-50.0 μg/mL) hydrate damages the fungal cells and reduces their viability[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
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Cell Line:C.albicans yeast cells (strain ATCC 26310 and strain TW)
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Concentration:0.1, 0.5, 5.0, 50.0 μg/mL
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Incubation Time:24 hours
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Result:The MICs against both strains were 0.5 μg/mL.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Female NYLAR mice (weight, 18 to 20 g; infected intravenously with C. albicans blastoconidia)[4]
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Dosage:5, 10, 15 and 20 mg/kg (Pharmacokinetic Analysis)
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Administration:Given i.p. as a single dose
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Result:T1/2=2.4 h
Essai clinique
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Chemical Information
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CAS No. 155347-36-7
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Masse moléculaire 324.29
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Formule C13H14F2N6O2
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SMILES
FC1=CC=C(C(O)(CN2C=NC=N2)CN3C=NC=N3)C(F)=C1.O
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Synonyms
UK 49858 hydrate
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (21)
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Journal Impact Factor
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Most Recent
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Signal Transduct Target Ther
Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]2025 Dec 15;10(1):406. PMID: 41392286 -
Sci Adv
E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation. [Abstract]2021 May 7;7(19):eabe5171. PMID: 33962939
Fluconazole hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]
Fungal burden of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.
Fluconazole hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]
Weight loss of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.
Fluconazole hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]
Colon length of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.
Fluconazole hydrate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]
Histological analysis of DSS (2.5%)–treated Cblf/fCD11cCre/+ and c-Cblf/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.
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J Hazard Mater
Stereostructure-activity mechanism of cyproconazole by cytochrome P450 in rat liver microsomes: A combined experimental and computational study. [Abstract]2021 Aug 15:416:125764. PMID: 33827004 -
Environ Int
2019 Jun:127:694-703. PMID: 30991225 -
Antioxidants (Basel)
Hyssopus cuspidatus Boriss Volatile Extract (SXC): A Dual-Action Antioxidant and Antifungal Agent Targeting Candida albicans Pathogenicity and Vulvovaginal Candidiasis via Host Oxidative Stress Modulation and Fungal Metabolic Reprogramming. [Abstract]2025 Aug 25;14(9):1046. PMID: 41008953 -
Environ Pollut
Assessing environmental and human health risks: Insight from the enantioselective metabolism and degradation of fenpropidin. [Abstract]2024 Aug 15:355:124214. PMID: 38801883 -
J Agric Food Chem
Enantioselective Metabolic Mechanism and Metabolism Pathway of Pydiflumetofen in Rat Liver Microsomes: In Vitro and In Silico Study. [Abstract]2022 Mar 2;70(8):2520-2528. PMID: 35184556 -
Microb Biotechnol
Repurposing the FDA-approved anticancer agent ponatinib as a fluconazole potentiator by suppression of multidrug efflux and Pma1 expression in a broad spectrum of yeast species. [Abstract]2022 Feb;15(2):482-498. PMID: 33955652
Fluconazole hydrate purchased from MedChemExpress. Usage Cited in: Microb Biotechnol. 2022 Feb;15(2):482-498. [Abstract]
Candida albicans (SC5314) was placed in YPD medium and serially diluted with fluconazole, panatinib, or both. OD600 values were measured every 15 minutes at 30°C, and FICI values were calculated according to the CLSI Broth Microdilution Reference Guide (M38-A)
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Transl Res
A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1. [Abstract]2022 Sep:247:39-57. PMID: 35452875 -
Front Microbiol
Ire1 inhibitors attenuate Candida albicans pathogenicity and demonstrate potential for application in antifungal therapy. [Abstract]2025 Sep 3:16:1648467. PMID: 40969430 -
Probiotics Antimicrob Proteins
Screening the γ-core Motif Peptides of Ascomycetous Antifungal Proteins for Antifungal Activity and Potential Therapeutic Applicability. [Abstract]2026 Jan 6. PMID: 41493708 -
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Microbiol Spectr
Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis. [Abstract]2025 May 6;13(5):e0318524. PMID: 40162832 -
Bioorg Med Chem
Evaluation of artemisinin derivative artemether as a fluconazole potentiator through inhibition of Pdr5. [Abstract]2021 Aug 15:44:116293. PMID: 34243044 -
Drug Test Anal
High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]2021 Feb;13(2):283-298. PMID: 32852861 -
J Mycol Med
In vitro synergistic effect of minocycline combined with antifungals against Cryptococcus neoformans. [Abstract]2022 Mar;32(1):101227. PMID: 34800920 -
Open Life Sci
2025 Apr 29;20(1):20221062. PMID: 40321158 -
Eur J Drug Metab Pharmacokinet
Evaluation of an Ussing Chamber System Equipped with Rat Intestinal Tissues to Predict Intestinal Absorption and Metabolism in Humans. [Abstract]2022 Sep;47(5):639-652. PMID: 35733077 -
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Pureté et documentation
Références
[1]. H Yamaguchi, et al. [In vitro activity of fluconazole, a novel bistriazole antifungal agent]. Jpn J Antibiot. 1989 Jan;42(1):1-16. [Content Brief]
[2]. M A Pfaller, et al. Interpretive breakpoints for fluconazole and Candida revisited: a blueprint for the future of antifungal susceptibility testing. Clin Microbiol Rev. 2006 Apr;19(2):435-47. [Content Brief]
[3]. P G Sohnle, et al. Effect of fluconazole on viability of Candida albicans over extended periods of time. Antimicrob Agents Chemother. 1996 Nov;40(11):2622-5. [Content Brief]
[4]. A Louie, et al. Pharmacodynamics of fluconazole in a murine model of systemic candidiasis. Antimicrob Agents Chemother. 1998 May;42(5):1105-9. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Fluconazole hydrate Related Classifications
HY-B0101A Related Classifications
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