Cat. No.: HY-B0101B

Fluconazole mesylate

(Synonyms: UK 49858 mesylate)

21 Cited Publications

Customer Review

Based on 21 publication(s) in Google Scholar

Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections.

For research use only. We do not sell to patients.

CAS No.: 159532-41-9
Formula: C₁₄H₁₆F₂N₆O₄S
Molecular Weight:402.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (276 KB)

Fluconazole mesylate Chemical Structure

CAS No.: 159532-41-9

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Biological Activity

Description

Fluconazole (mesylate) is a triazole antifungal drug used in the treatment and prevention of superficial and systemic fungal infections. Target: Antifungal Fluconazole (mesylate) is the mesylate salt form of fluconazole, which is a triazole antifungal intended for oral treatment of superficial and systemic mycoses. In tests done in standard mycological media, the compound had minimal inhibitory concentrations against pathogenic Candida species that were usually in excess of 100 mg/l. Fluconazole inhibited branching and hyphal development in C. albicans at concentrations as low as 10(-6) M (0.3 mg/l), but miconazole and ketoconazole were still active in these tests at concentrations 100 times lower than this [1]. Oral fluconazole was not associated with a significantly increased risk of birth defects overall or of 14 of the 15 specific birth defects of previous concern. Fluconazole exposure may confer an increased risk of tetralogy of Fallot [2]. Fluconazole is predicted to be ineffective against Cryptococcus gattii in the koala as a sole therapeutic agent administered at 10 mg/kg p.o. every 12 h [3]. Clinical indications: Balanitis; Candida infection; Cryptococcus infection; Cryptococcus neoformans meningitis; Dermatomycosis; Female genital tract infection; Fungal infection; Fungal respiratory tract infection; Fungal urinary tract infection; Prophylaxis; Tinea capitis; Tinea corporis; Tinea cruris; Tinea pedis . Toxicity: Symptoms of overdose include hallucinations and paranoid behavior.

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Chemical Information

CAS No. 159532-41-9
Molecular Weight 402.38
Formula C₁₄H₁₆F₂N₆O₄S
SMILES

FC1=CC=C(C(O)(CN2C=NC=N2)CN3C=NC=N3)C(F)=C1.CS(=O)(O)=O
Synonyms

UK 49858 mesylate
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (21)

All In Vivo Efficacy StudyMicrobiological AssayHistological Imaging/Staining

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Signal Transduct Target Ther

Selective depletion of tumor-associated SAMHD1 enhances chemotherapeutic efficacy and antitumor immune responses. [Abstract]

2025 Dec 15;10(1):406. PMID: 41392286
Sci Adv

E3 ligase c-Cbl regulates intestinal inflammation through suppressing fungi-induced noncanonical NF-κB activation. [Abstract]

2021 May 7;7(19):eabe5171. PMID: 33962939

Fluconazole mesylate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]

Fungal burden of DSS (2.5%)–treated Cbl^f/fCD11c^Cre/+ and c-Cbl^f/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

Fluconazole mesylate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]

Weight loss of DSS (2.5%)–treated Cbl^f/fCD11c^Cre/+ and c-Cbl^f/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

Fluconazole mesylate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]

Colon length of DSS (2.5%)–treated Cbl^f/fCD11c^Cre/+ and c-Cbl^f/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.

Fluconazole mesylate purchased from MedChemExpress. Usage Cited in: Sci Adv. 2021 May 7;7(19):eabe5171. [Abstract]

Histological analysis of DSS (2.5%)–treated Cbl^f/fCD11c^Cre/+ and c-Cbl^f/f mice (n = 4 to 7 mice group in each experiment), which were pretreated with or without fluconazole (0.5 mg/mL, 15 days) in drinking water.
J Hazard Mater

Stereostructure-activity mechanism of cyproconazole by cytochrome P450 in rat liver microsomes: A combined experimental and computational study. [Abstract]

2021 Aug 15:416:125764. PMID: 33827004
Environ Int

A potential biomarker of isofenphos-methyl in humans: A chiral view. [Abstract]

2019 Jun:127:694-703. PMID: 30991225
Antioxidants (Basel)

Hyssopus cuspidatus Boriss Volatile Extract (SXC): A Dual-Action Antioxidant and Antifungal Agent Targeting Candida albicans Pathogenicity and Vulvovaginal Candidiasis via Host Oxidative Stress Modulation and Fungal Metabolic Reprogramming. [Abstract]

2025 Aug 25;14(9):1046. PMID: 41008953
Environ Pollut

Assessing environmental and human health risks: Insight from the enantioselective metabolism and degradation of fenpropidin. [Abstract]

2024 Aug 15:355:124214. PMID: 38801883
J Agric Food Chem

Enantioselective Metabolic Mechanism and Metabolism Pathway of Pydiflumetofen in Rat Liver Microsomes: In Vitro and In Silico Study. [Abstract]

2022 Mar 2;70(8):2520-2528. PMID: 35184556
Microb Biotechnol

Repurposing the FDA-approved anticancer agent ponatinib as a fluconazole potentiator by suppression of multidrug efflux and Pma1 expression in a broad spectrum of yeast species. [Abstract]

2022 Feb;15(2):482-498. PMID: 33955652

Fluconazole mesylate purchased from MedChemExpress. Usage Cited in: Microb Biotechnol. 2022 Feb;15(2):482-498. [Abstract]

Candida albicans (SC5314) was placed in YPD medium and serially diluted with fluconazole, panatinib, or both. OD600 values were measured every 15 minutes at 30°C, and FICI values were calculated according to the CLSI Broth Microdilution Reference Guide (M38-A)
Transl Res

A dual action small molecule enhances azoles and overcomes resistance through co-targeting Pdr5 and Vma1. [Abstract]

2022 Sep:247:39-57. PMID: 35452875
Front Microbiol

Ire1 inhibitors attenuate Candida albicans pathogenicity and demonstrate potential for application in antifungal therapy. [Abstract]

2025 Sep 3:16:1648467. PMID: 40969430
Probiotics Antimicrob Proteins

Screening the γ-core Motif Peptides of Ascomycetous Antifungal Proteins for Antifungal Activity and Potential Therapeutic Applicability. [Abstract]

2026 Jan 6. PMID: 41493708
Microchem J

2026 Mar 27.
Microbiol Spectr

Synergistic antifungal activity of minocycline as an effective augmenting agent of fluconazole against drug-resistant Candida tropicalis. [Abstract]

2025 May 6;13(5):e0318524. PMID: 40162832
Bioorg Med Chem

Evaluation of artemisinin derivative artemether as a fluconazole potentiator through inhibition of Pdr5. [Abstract]

2021 Aug 15:44:116293. PMID: 34243044
Drug Test Anal

High-throughput liquid chromatography tandem mass spectrometry assay as initial testing procedure for analysis of total urinary fraction. [Abstract]

2021 Feb;13(2):283-298. PMID: 32852861
J Mycol Med

In vitro synergistic effect of minocycline combined with antifungals against Cryptococcus neoformans. [Abstract]

2022 Mar;32(1):101227. PMID: 34800920
Open Life Sci

Effects of Ire1 gene on virulence and pathogenicity of Candida albicans. [Abstract]

2025 Apr 29;20(1):20221062. PMID: 40321158
Eur J Drug Metab Pharmacokinet

Evaluation of an Ussing Chamber System Equipped with Rat Intestinal Tissues to Predict Intestinal Absorption and Metabolism in Humans. [Abstract]

2022 Sep;47(5):639-652. PMID: 35733077
University of Szeged

2026.
Orebro University

2024.
bioRxiv

2024 May 14.

Purity & Documentation

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Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (276 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Odds, F.C., S.L. Cheesman, and A.B. Abbott, Antifungal effects of fluconazole (UK 49858), a new triazole antifungal, in vitro. J Antimicrob Chemother, 1986. 18(4): p. 473-8. [Content Brief]

[2]. Molgaard-Nielsen, D., B. Pasternak, and A. Hviid, Use of oral fluconazole during pregnancy and the risk of birth defects. N Engl J Med, 2013. 369(9): p. 830-9. [Content Brief]

[3]. Black, L.A., et al., Pharmacokinetics of fluconazole following intravenous and oral administration to koalas (Phascolarctos cinereus). J Vet Pharmacol Ther, 2013. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Fluconazole mesylate

21 Cited Publications

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Fluconazole mesylate

Publications Citing Use of MedChemExpress (MCE) Fluconazole mesylate

All Antibiotic Isoforms

Biological Activity

Chemical Information

Publications (21)

Purity & Documentation

References

Calculators

Help & FAQs

Fluconazole mesylate Related Classifications

HY-B0101B Related Classifications